Gigantomastia and Macroprolactinemia Responding to Cabergoline Treatment: A Case Report and Minireview of the Literature
Background. Macroprolactinemia is defined as predominance of high molecular weight prolactin forms in the circulation. Although macroprolactin is considered as a biologically inactive molecule, some authorities suggest treatment in symptomatic cases. Gigantomastia is defined as excess breast tissue...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Case Reports in Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2016/3576024 |
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| author | Fatma Dilek Dellal Didem Ozdemir Cevdet Aydin Gulfem Kaya Reyhan Ersoy Bekir Cakir |
| author_facet | Fatma Dilek Dellal Didem Ozdemir Cevdet Aydin Gulfem Kaya Reyhan Ersoy Bekir Cakir |
| author_sort | Fatma Dilek Dellal |
| collection | DOAJ |
| description | Background. Macroprolactinemia is defined as predominance of high molecular weight prolactin forms in the circulation. Although macroprolactin is considered as a biologically inactive molecule, some authorities suggest treatment in symptomatic cases. Gigantomastia is defined as excess breast tissue and most cases in the literature were treated by surgical intervention. Case. A 44-year-old woman was admitted to our clinic with gigantomastia and galactorrhea. The patient had a demand for surgical therapy. In laboratory examination, she had hyperprolactinemia and macroprolactinemia. Pituitary imaging revealed 6 mm microadenoma in right side of the hypophysis. Since she was symptomatic, cabergolin treatment was started. Macroprolactin became negative, breast circumference decreased significantly, and galactorrhea resolved after treatment. Conclusion. Gigantomastia might be the presenting symptom in patients with macroprolactinemia. In these patients medical treatment with cabergoline may be used initially as an alternative to surgical approach. |
| format | Article |
| id | doaj-art-befc1870cbb54fb99524f10eb926bdda |
| institution | Kabale University |
| issn | 2090-6501 2090-651X |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Endocrinology |
| spelling | doaj-art-befc1870cbb54fb99524f10eb926bdda2025-02-03T06:01:15ZengWileyCase Reports in Endocrinology2090-65012090-651X2016-01-01201610.1155/2016/35760243576024Gigantomastia and Macroprolactinemia Responding to Cabergoline Treatment: A Case Report and Minireview of the LiteratureFatma Dilek Dellal0Didem Ozdemir1Cevdet Aydin2Gulfem Kaya3Reyhan Ersoy4Bekir Cakir5Department of Endocrinology and Metabolism, Ataturk Training and Research Hospital, 06800 Ankara, TurkeyDepartment of Endocrinology and Metabolism, Faculty of Medicine, Yildirim Beyazit University, 06800 Ankara, TurkeyDepartment of Endocrinology and Metabolism, Faculty of Medicine, Yildirim Beyazit University, 06800 Ankara, TurkeyDepartment of Endocrinology and Metabolism, Ataturk Training and Research Hospital, 06800 Ankara, TurkeyDepartment of Endocrinology and Metabolism, Faculty of Medicine, Yildirim Beyazit University, 06800 Ankara, TurkeyDepartment of Endocrinology and Metabolism, Faculty of Medicine, Yildirim Beyazit University, 06800 Ankara, TurkeyBackground. Macroprolactinemia is defined as predominance of high molecular weight prolactin forms in the circulation. Although macroprolactin is considered as a biologically inactive molecule, some authorities suggest treatment in symptomatic cases. Gigantomastia is defined as excess breast tissue and most cases in the literature were treated by surgical intervention. Case. A 44-year-old woman was admitted to our clinic with gigantomastia and galactorrhea. The patient had a demand for surgical therapy. In laboratory examination, she had hyperprolactinemia and macroprolactinemia. Pituitary imaging revealed 6 mm microadenoma in right side of the hypophysis. Since she was symptomatic, cabergolin treatment was started. Macroprolactin became negative, breast circumference decreased significantly, and galactorrhea resolved after treatment. Conclusion. Gigantomastia might be the presenting symptom in patients with macroprolactinemia. In these patients medical treatment with cabergoline may be used initially as an alternative to surgical approach.http://dx.doi.org/10.1155/2016/3576024 |
| spellingShingle | Fatma Dilek Dellal Didem Ozdemir Cevdet Aydin Gulfem Kaya Reyhan Ersoy Bekir Cakir Gigantomastia and Macroprolactinemia Responding to Cabergoline Treatment: A Case Report and Minireview of the Literature Case Reports in Endocrinology |
| title | Gigantomastia and Macroprolactinemia Responding to Cabergoline Treatment: A Case Report and Minireview of the Literature |
| title_full | Gigantomastia and Macroprolactinemia Responding to Cabergoline Treatment: A Case Report and Minireview of the Literature |
| title_fullStr | Gigantomastia and Macroprolactinemia Responding to Cabergoline Treatment: A Case Report and Minireview of the Literature |
| title_full_unstemmed | Gigantomastia and Macroprolactinemia Responding to Cabergoline Treatment: A Case Report and Minireview of the Literature |
| title_short | Gigantomastia and Macroprolactinemia Responding to Cabergoline Treatment: A Case Report and Minireview of the Literature |
| title_sort | gigantomastia and macroprolactinemia responding to cabergoline treatment a case report and minireview of the literature |
| url | http://dx.doi.org/10.1155/2016/3576024 |
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