Empagliflozin ameliorates RSL3-induced ferroptosis in vascular endothelial cells via the NRF2/HO-1 pathway

Empagliflozin ameliorates RSL3-induced ferroptosis in vascular endothelial cells via the NRF2/HO-1 pathway

Abstract Endothelial cell dysfunction is a fundamental injury of atherosclerosis cardiovascular disease (ASCVD), closely linked to ferroptosis, which is a novel type of cell death induced by iron-dependent lipid peroxidation. Several clinical trials have suggested that empagliflozin, a selective inh...

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Bibliographic Details
Main Authors: ZiLin Wang, SiMiao Liu, JiaHao Shi, Di Chen, ShaoLin Li, ShengQin Yu, SiXu Liu, KaiJing Yang, Wan Zhang, Xue Gao, ShuYing Zhang
Format: Article
Language:English
Published: BMC 2025-06-01
Series:BMC Cardiovascular Disorders
Subjects:
Empagliflozin
Ferroptosis
Endothelial cell injury
NRF2
HO-1
Online Access:https://doi.org/10.1186/s12872-025-04890-7
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