Low urinary selenium concentration is associated with nonthyroidal illness syndrome in hospitalized patients with COVID-19
ABSTRACT Objective: This study aimed to assess urinary selenium concentration (USC) and its correlation with non-thyroidal illness syndrome (NTIS) and inflammatory markers in hospitalized adult patients with COVID-19. Subjects and methods: A prospective study was conducted to investigate urinary s...
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Brazilian Society of Endocrinology and Metabolism
2025-06-01
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| Series: | Archives of Endocrinology and Metabolism |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972025000301500&lng=en&tlng=en |
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| author | Sara Moreira Anunciação Renata de Oliveira Campos Fabyan Esberard de Lima Beltrão Déborah Araújo Morais Wellington Tavares de Sousa Júnior Fernando Barbosa Júnior Jéssica Fernanda Cassemiro Pedro Resende Ferreira Rende Fabio Hecht Helton Estrela Ramos |
| author_facet | Sara Moreira Anunciação Renata de Oliveira Campos Fabyan Esberard de Lima Beltrão Déborah Araújo Morais Wellington Tavares de Sousa Júnior Fernando Barbosa Júnior Jéssica Fernanda Cassemiro Pedro Resende Ferreira Rende Fabio Hecht Helton Estrela Ramos |
| author_sort | Sara Moreira Anunciação |
| collection | DOAJ |
| description | ABSTRACT Objective: This study aimed to assess urinary selenium concentration (USC) and its correlation with non-thyroidal illness syndrome (NTIS) and inflammatory markers in hospitalized adult patients with COVID-19. Subjects and methods: A prospective study was conducted to investigate urinary selenium (Se) concentration in adult patients hospitalized with COVID-19 between June and August 2020. Urine and serum samples were collected before complications occurred, always within the first 48 hours after onset. A total of 121 patients were stratified into three tertiles based on USC: (i) USC < 25 μg/L (40), (ii) USC 25-39 μg/L (41), and (iii) USC > 39 μg/L (40). ICP-MS was employed to measure urinary Se concentration. NTIS was defined by free triiodothyronine below 2.3 pg/L accompanied by low or normal thyroid-stimulating hormone levels. Results: NTIS was observed in a low prevalence (5.7%) and was significantly associated with patients having the lowest USC (n = 6, p = 0.008). Thyroiditis was the most prevalent thyroid complication (23.9%); however, there was no significant association with USC (p > 0.05). Conclusion: The association between low USC and NTIS was evident in this cohort. |
| format | Article |
| id | doaj-art-befa6459cc6845228cd7615efc9b0fd2 |
| institution | OA Journals |
| issn | 2359-4292 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Brazilian Society of Endocrinology and Metabolism |
| record_format | Article |
| series | Archives of Endocrinology and Metabolism |
| spelling | doaj-art-befa6459cc6845228cd7615efc9b0fd22025-08-20T02:38:45ZengBrazilian Society of Endocrinology and MetabolismArchives of Endocrinology and Metabolism2359-42922025-06-0169310.20945/2359-4292-2024-0113Low urinary selenium concentration is associated with nonthyroidal illness syndrome in hospitalized patients with COVID-19Sara Moreira Anunciaçãohttps://orcid.org/0000-0002-8080-4900Renata de Oliveira Camposhttps://orcid.org/0000-0002-2888-4798Fabyan Esberard de Lima Beltrãohttps://orcid.org/0000-0001-9713-2584Déborah Araújo Moraishttps://orcid.org/0000-0003-2390-956XWellington Tavares de Sousa Júniorhttps://orcid.org/0000-0001-8901-3219Fernando Barbosa Júniorhttps://orcid.org/0000-0002-2501-958XJéssica Fernanda Cassemirohttps://orcid.org/0000-0002-3119-769XPedro Resende Ferreira Rendehttps://orcid.org/0000-0001-8999-8871Fabio Hechthttps://orcid.org/0000-0001-9110-2587Helton Estrela Ramoshttps://orcid.org/0000-0002-2900-2099ABSTRACT Objective: This study aimed to assess urinary selenium concentration (USC) and its correlation with non-thyroidal illness syndrome (NTIS) and inflammatory markers in hospitalized adult patients with COVID-19. Subjects and methods: A prospective study was conducted to investigate urinary selenium (Se) concentration in adult patients hospitalized with COVID-19 between June and August 2020. Urine and serum samples were collected before complications occurred, always within the first 48 hours after onset. A total of 121 patients were stratified into three tertiles based on USC: (i) USC < 25 μg/L (40), (ii) USC 25-39 μg/L (41), and (iii) USC > 39 μg/L (40). ICP-MS was employed to measure urinary Se concentration. NTIS was defined by free triiodothyronine below 2.3 pg/L accompanied by low or normal thyroid-stimulating hormone levels. Results: NTIS was observed in a low prevalence (5.7%) and was significantly associated with patients having the lowest USC (n = 6, p = 0.008). Thyroiditis was the most prevalent thyroid complication (23.9%); however, there was no significant association with USC (p > 0.05). Conclusion: The association between low USC and NTIS was evident in this cohort.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972025000301500&lng=en&tlng=enSeleniumCOVID-19thyroid, nonthyroidal illness syndrome |
| spellingShingle | Sara Moreira Anunciação Renata de Oliveira Campos Fabyan Esberard de Lima Beltrão Déborah Araújo Morais Wellington Tavares de Sousa Júnior Fernando Barbosa Júnior Jéssica Fernanda Cassemiro Pedro Resende Ferreira Rende Fabio Hecht Helton Estrela Ramos Low urinary selenium concentration is associated with nonthyroidal illness syndrome in hospitalized patients with COVID-19 Archives of Endocrinology and Metabolism Selenium COVID-19 thyroid, nonthyroidal illness syndrome |
| title | Low urinary selenium concentration is associated with nonthyroidal illness syndrome in hospitalized patients with COVID-19 |
| title_full | Low urinary selenium concentration is associated with nonthyroidal illness syndrome in hospitalized patients with COVID-19 |
| title_fullStr | Low urinary selenium concentration is associated with nonthyroidal illness syndrome in hospitalized patients with COVID-19 |
| title_full_unstemmed | Low urinary selenium concentration is associated with nonthyroidal illness syndrome in hospitalized patients with COVID-19 |
| title_short | Low urinary selenium concentration is associated with nonthyroidal illness syndrome in hospitalized patients with COVID-19 |
| title_sort | low urinary selenium concentration is associated with nonthyroidal illness syndrome in hospitalized patients with covid 19 |
| topic | Selenium COVID-19 thyroid, nonthyroidal illness syndrome |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972025000301500&lng=en&tlng=en |
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