Low urinary selenium concentration is associated with nonthyroidal illness syndrome in hospitalized patients with COVID-19

Low urinary selenium concentration is associated with nonthyroidal illness syndrome in hospitalized patients with COVID-19

ABSTRACT Objective: This study aimed to assess urinary selenium concentration (USC) and its correlation with non-thyroidal illness syndrome (NTIS) and inflammatory markers in hospitalized adult patients with COVID-19. Subjects and methods: A prospective study was conducted to investigate urinary s...

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Main Authors: Sara Moreira Anunciação, Renata de Oliveira Campos, Fabyan Esberard de Lima Beltrão, Déborah Araújo Morais, Wellington Tavares de Sousa Júnior, Fernando Barbosa Júnior, Jéssica Fernanda Cassemiro, Pedro Resende Ferreira Rende, Fabio Hecht, Helton Estrela Ramos
Format: Article
Language:English
Published: Brazilian Society of Endocrinology and Metabolism 2025-06-01
Series:Archives of Endocrinology and Metabolism
Subjects:
Selenium
COVID-19
thyroid, nonthyroidal illness syndrome
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972025000301500&lng=en&tlng=en
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Summary:ABSTRACT Objective: This study aimed to assess urinary selenium concentration (USC) and its correlation with non-thyroidal illness syndrome (NTIS) and inflammatory markers in hospitalized adult patients with COVID-19. Subjects and methods: A prospective study was conducted to investigate urinary selenium (Se) concentration in adult patients hospitalized with COVID-19 between June and August 2020. Urine and serum samples were collected before complications occurred, always within the first 48 hours after onset. A total of 121 patients were stratified into three tertiles based on USC: (i) USC < 25 μg/L (40), (ii) USC 25-39 μg/L (41), and (iii) USC > 39 μg/L (40). ICP-MS was employed to measure urinary Se concentration. NTIS was defined by free triiodothyronine below 2.3 pg/L accompanied by low or normal thyroid-stimulating hormone levels. Results: NTIS was observed in a low prevalence (5.7%) and was significantly associated with patients having the lowest USC (n = 6, p = 0.008). Thyroiditis was the most prevalent thyroid complication (23.9%); however, there was no significant association with USC (p > 0.05). Conclusion: The association between low USC and NTIS was evident in this cohort.
ISSN:2359-4292

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