Studies of Slc30a10 Deficiency in Mice Reveal That Intestinal Iron Transporters Dmt1 and Ferroportin Transport ManganeseSummary

Studies of Slc30a10 Deficiency in Mice Reveal That Intestinal Iron Transporters Dmt1 and Ferroportin Transport ManganeseSummary

Background & Aims: SLC11A2 (DMT1) and SLC40A1 (ferroportin) are essential for dietary iron absorption, but their role in manganese transport is debated. SLC30A10 deficiency causes severe manganese excess due to loss of gastrointestinal manganese excretion. Patients are treated with chelators...

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Bibliographic Details
Main Authors: Milankumar Prajapati, Jared Z. Zhang, Grace S. Chong, Lauren Chiu, Courtney J. Mercadante, Heather L. Kowalski, Olga Antipova, Barry Lai, Martina Ralle, Brian P. Jackson, Tracy Punshon, Shuling Guo, Mariam Aghajan, Thomas B. Bartnikas
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Cellular and Molecular Gastroenterology and Hepatology
Subjects:
Absorption
Homeostasis
Metal
Online Access:http://www.sciencedirect.com/science/article/pii/S2352345X2500030X
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