Epithelial-to-mesenchymal transition drives cancer genomic instability
Abstract Epithelial-to-Mesenchymal Transition (EMT) is a form of embryonic cell plasticity reactivated in adult cells during injury and cancer. A recent study by Perelli et al. demonstrates that EMT confers an evolutionary advantage to tumors by inducing chromosomal instability, structural genomic r...
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| Format: | Article |
| Language: | English |
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BMC
2025-04-01
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| Series: | Journal of Experimental & Clinical Cancer Research |
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| Online Access: | https://doi.org/10.1186/s13046-025-03402-x |
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| author | Julienne L. Carstens Sara Lovisa |
| author_facet | Julienne L. Carstens Sara Lovisa |
| author_sort | Julienne L. Carstens |
| collection | DOAJ |
| description | Abstract Epithelial-to-Mesenchymal Transition (EMT) is a form of embryonic cell plasticity reactivated in adult cells during injury and cancer. A recent study by Perelli et al. demonstrates that EMT confers an evolutionary advantage to tumors by inducing chromosomal instability, structural genomic rearrangements and chromothripsis, thus favoring the emergence of high-fitness malignant clones. |
| format | Article |
| id | doaj-art-bef29b8b971d4ccaaaca246094c32275 |
| institution | DOAJ |
| issn | 1756-9966 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Experimental & Clinical Cancer Research |
| spelling | doaj-art-bef29b8b971d4ccaaaca246094c322752025-08-20T02:55:24ZengBMCJournal of Experimental & Clinical Cancer Research1756-99662025-04-014411510.1186/s13046-025-03402-xEpithelial-to-mesenchymal transition drives cancer genomic instabilityJulienne L. Carstens0Sara Lovisa1Department of Medicine, Division of Hematology & Oncology, University of Alabama at BirminghamDepartment of Biomedical Sciences, Humanitas UniversityAbstract Epithelial-to-Mesenchymal Transition (EMT) is a form of embryonic cell plasticity reactivated in adult cells during injury and cancer. A recent study by Perelli et al. demonstrates that EMT confers an evolutionary advantage to tumors by inducing chromosomal instability, structural genomic rearrangements and chromothripsis, thus favoring the emergence of high-fitness malignant clones.https://doi.org/10.1186/s13046-025-03402-xEMTEpithelial-to-mesenchymal transitionGenomic instabilityCell plasticityCancer |
| spellingShingle | Julienne L. Carstens Sara Lovisa Epithelial-to-mesenchymal transition drives cancer genomic instability Journal of Experimental & Clinical Cancer Research EMT Epithelial-to-mesenchymal transition Genomic instability Cell plasticity Cancer |
| title | Epithelial-to-mesenchymal transition drives cancer genomic instability |
| title_full | Epithelial-to-mesenchymal transition drives cancer genomic instability |
| title_fullStr | Epithelial-to-mesenchymal transition drives cancer genomic instability |
| title_full_unstemmed | Epithelial-to-mesenchymal transition drives cancer genomic instability |
| title_short | Epithelial-to-mesenchymal transition drives cancer genomic instability |
| title_sort | epithelial to mesenchymal transition drives cancer genomic instability |
| topic | EMT Epithelial-to-mesenchymal transition Genomic instability Cell plasticity Cancer |
| url | https://doi.org/10.1186/s13046-025-03402-x |
| work_keys_str_mv | AT juliennelcarstens epithelialtomesenchymaltransitiondrivescancergenomicinstability AT saralovisa epithelialtomesenchymaltransitiondrivescancergenomicinstability |