T cell-derived small extracellular vesicles in cancer–immune interactions
Abstract Small extracellular vesicles (sEVs) are lipid-encapsulated nanoparticles released following the endocytic fusion of multivesicular bodies with the plasma membrane. sEVs are secreted by most eukaryotic cells, and they contain proteins, RNAs and DNA. They act primarily as mediators of interce...
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| Format: | Article |
| Language: | English |
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Springer
2025-06-01
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| Series: | Cancer Immunology, Immunotherapy |
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| Online Access: | https://doi.org/10.1007/s00262-025-04109-w |
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| author | Ma Janelle Chichoco Garcia Su Su Thae Hnit Elena Shklovskaya Yuling Wang |
| author_facet | Ma Janelle Chichoco Garcia Su Su Thae Hnit Elena Shklovskaya Yuling Wang |
| author_sort | Ma Janelle Chichoco Garcia |
| collection | DOAJ |
| description | Abstract Small extracellular vesicles (sEVs) are lipid-encapsulated nanoparticles released following the endocytic fusion of multivesicular bodies with the plasma membrane. sEVs are secreted by most eukaryotic cells, and they contain proteins, RNAs and DNA. They act primarily as mediators of intercellular communication through the transport of their contents from donor to recipient cells. Immune cells, including T cells, secrete sEVs following activation. T cell-derived sEVs (T-sEVs) have gained attention in cell-to-cell signalling and as promising immunotherapeutic agents. Growing evidence suggests that T-sEVs are key players in cancer immunotherapy responses. A better understanding of T-sEVs production and properties is key for grasping their biological functions. Extensive current literature on tumour-derived sEVs and their applications in diagnostics or therapeutics is in disconnect with fewer reports on T-sEVs. In this review, we discuss T-sEV biogenesis, their roles in cell-to-cell communication and potential applications in immunotherapy for cancer. |
| format | Article |
| id | doaj-art-bef052e5510742e3b633ec09b7f3a2be |
| institution | Kabale University |
| issn | 1432-0851 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Springer |
| record_format | Article |
| series | Cancer Immunology, Immunotherapy |
| spelling | doaj-art-bef052e5510742e3b633ec09b7f3a2be2025-08-20T04:02:57ZengSpringerCancer Immunology, Immunotherapy1432-08512025-06-0174811410.1007/s00262-025-04109-wT cell-derived small extracellular vesicles in cancer–immune interactionsMa Janelle Chichoco Garcia0Su Su Thae Hnit1Elena Shklovskaya2Yuling Wang3School of Natural Sciences, Faculty of Science and Engineering, Macquarie UniversitySchool of Natural Sciences, Faculty of Science and Engineering, Macquarie UniversityMacquarie Medical School, Faculty of Medicine, Health and Human Sciences, Macquarie UniversitySchool of Natural Sciences, Faculty of Science and Engineering, Macquarie UniversityAbstract Small extracellular vesicles (sEVs) are lipid-encapsulated nanoparticles released following the endocytic fusion of multivesicular bodies with the plasma membrane. sEVs are secreted by most eukaryotic cells, and they contain proteins, RNAs and DNA. They act primarily as mediators of intercellular communication through the transport of their contents from donor to recipient cells. Immune cells, including T cells, secrete sEVs following activation. T cell-derived sEVs (T-sEVs) have gained attention in cell-to-cell signalling and as promising immunotherapeutic agents. Growing evidence suggests that T-sEVs are key players in cancer immunotherapy responses. A better understanding of T-sEVs production and properties is key for grasping their biological functions. Extensive current literature on tumour-derived sEVs and their applications in diagnostics or therapeutics is in disconnect with fewer reports on T-sEVs. In this review, we discuss T-sEV biogenesis, their roles in cell-to-cell communication and potential applications in immunotherapy for cancer.https://doi.org/10.1007/s00262-025-04109-wT cellsSmall extracellular vesiclesIntercellular communicationCD4+ T cellsCD8+ T cells |
| spellingShingle | Ma Janelle Chichoco Garcia Su Su Thae Hnit Elena Shklovskaya Yuling Wang T cell-derived small extracellular vesicles in cancer–immune interactions Cancer Immunology, Immunotherapy T cells Small extracellular vesicles Intercellular communication CD4+ T cells CD8+ T cells |
| title | T cell-derived small extracellular vesicles in cancer–immune interactions |
| title_full | T cell-derived small extracellular vesicles in cancer–immune interactions |
| title_fullStr | T cell-derived small extracellular vesicles in cancer–immune interactions |
| title_full_unstemmed | T cell-derived small extracellular vesicles in cancer–immune interactions |
| title_short | T cell-derived small extracellular vesicles in cancer–immune interactions |
| title_sort | t cell derived small extracellular vesicles in cancer immune interactions |
| topic | T cells Small extracellular vesicles Intercellular communication CD4+ T cells CD8+ T cells |
| url | https://doi.org/10.1007/s00262-025-04109-w |
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