Effect of mixture metals on the fish (Carassius auratus) ATPase activity and its genotoxicity
The Carassius auratus genetoxicity and ATPase activity for mixture metals have been studied. The results demonstrated that there was negative linear correlation between the Na/K ATPase activity and the exposure concentration of mixture metals in the tissue of gill. brain and liver as well. The sensi...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Zhejiang University Press
2001-11-01
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| Series: | 浙江大学学报. 农业与生命科学版 |
| Subjects: | |
| Online Access: | https://www.academax.com/doi/10.3785/1008-9209.2001.06.0665 |
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| Summary: | The Carassius auratus genetoxicity and ATPase activity for mixture metals have been studied. The results demonstrated that there was negative linear correlation between the Na/K ATPase activity and the exposure concentration of mixture metals in the tissue of gill. brain and liver as well. The sensitivity order of the Na/K ATPase activity among the three tissues was brain>gill>liver for the mixture metal, their EC<sub>50</sub> was 1.63, 0.92, 2.02 mg/L respectively. The <sup>3</sup>H-TdR incorporation experiment demonstrated that the best sampling time was 6 h after injection. The mixture-metal toxicity for Carassius auratus was double effect, the DNA synthesis was damaged at lower concentration and would be inhibited at higher concentration; There is a significant correlationship between the Na/K ATPase activity and <sup>3</sup>H-TdR radioactivity in the tissue of liver and gill. |
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| ISSN: | 1008-9209 2097-5155 |