Efficacy of IVUS-guided stent implantation in patients with complex CAD: a meta-analysis based on RCTs
BackgroundThis study is to investigate the efficacy of stent implantation in patients with complex coronary artery disease (CAD) under intravascular ultrasound (IVUS) guidance and non-IVUS guidance.MethodsWe conducted a systematic search in PubMed, Web of Science, Cochran, and Embase for the article...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-11-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2024.1446014/full |
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| author | Anyi Xu Dongying Wang Bangsheng Chen Siyue Song Qiufeng Zhang Zuokun Zhu Min Dai Chenyi Wang |
| author_facet | Anyi Xu Dongying Wang Bangsheng Chen Siyue Song Qiufeng Zhang Zuokun Zhu Min Dai Chenyi Wang |
| author_sort | Anyi Xu |
| collection | DOAJ |
| description | BackgroundThis study is to investigate the efficacy of stent implantation in patients with complex coronary artery disease (CAD) under intravascular ultrasound (IVUS) guidance and non-IVUS guidance.MethodsWe conducted a systematic search in PubMed, Web of Science, Cochran, and Embase for the articles of IVUS-guided and non-IVUS-guided stent implantation in patients with complex CAD and reported related outcomes. We included major adverse cardiovascular events (MACE), myocardial infarction (MI), cardiac death and other outcome indicators. Relative ratio (RR) and 95% confidence interval (CI) were used for statistical analysis.ResultsA total of 5,173 subjects were included in 6 randomized control trials. The results showed that the incidence of MACE (RR: 0.63, 95% CI: 0.49–0.82, P < 0.001), cardiac death (RR: 0.61, 95% CI: 0.44–0.85, P = 0.004), target vessel revascularization (TVR) (P = 0.01), target lesion revascularization (TLR) (P = 0.03) and stent thrombosis (ST) (P = 0.002) in the experimental group (IVUS-guidance) was lower than that in the control group (non-IVUS-guidance). However, no statistical difference was observed between the both groups in the incidence of MI (P = 0.13) and all-cause death (P = 0.41).ConclusionsCompared with the non-IVUS-guided group, IVUS-guided stent implantation may be more effective for patients with complex CAD.Systematic Review RegistrationPROSPERO [CRD42024531366]. |
| format | Article |
| id | doaj-art-bee72c5dd8d842c5b14936ab084da8b2 |
| institution | Kabale University |
| issn | 2297-055X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj-art-bee72c5dd8d842c5b14936ab084da8b22024-11-28T06:33:13ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2024-11-011110.3389/fcvm.2024.14460141446014Efficacy of IVUS-guided stent implantation in patients with complex CAD: a meta-analysis based on RCTsAnyi Xu0Dongying Wang1Bangsheng Chen2Siyue Song3Qiufeng Zhang4Zuokun Zhu5Min Dai6Chenyi Wang7The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, ChinaThe First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, ChinaEmergency Medical Center, Ningbo Yinzhou No. 2 Hospital, Ningbo, Zhejiang, ChinaCollege of Basic Medical Sciences, Zhejiang Chinese Medical University, Zhejiang, ChinaThe First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, ChinaThe First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, ChinaThe Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, ChinaIntensive Care Unit, Ningbo Yinzhou No. 2 Hospital, Ningbo, Zhejiang, ChinaBackgroundThis study is to investigate the efficacy of stent implantation in patients with complex coronary artery disease (CAD) under intravascular ultrasound (IVUS) guidance and non-IVUS guidance.MethodsWe conducted a systematic search in PubMed, Web of Science, Cochran, and Embase for the articles of IVUS-guided and non-IVUS-guided stent implantation in patients with complex CAD and reported related outcomes. We included major adverse cardiovascular events (MACE), myocardial infarction (MI), cardiac death and other outcome indicators. Relative ratio (RR) and 95% confidence interval (CI) were used for statistical analysis.ResultsA total of 5,173 subjects were included in 6 randomized control trials. The results showed that the incidence of MACE (RR: 0.63, 95% CI: 0.49–0.82, P < 0.001), cardiac death (RR: 0.61, 95% CI: 0.44–0.85, P = 0.004), target vessel revascularization (TVR) (P = 0.01), target lesion revascularization (TLR) (P = 0.03) and stent thrombosis (ST) (P = 0.002) in the experimental group (IVUS-guidance) was lower than that in the control group (non-IVUS-guidance). However, no statistical difference was observed between the both groups in the incidence of MI (P = 0.13) and all-cause death (P = 0.41).ConclusionsCompared with the non-IVUS-guided group, IVUS-guided stent implantation may be more effective for patients with complex CAD.Systematic Review RegistrationPROSPERO [CRD42024531366].https://www.frontiersin.org/articles/10.3389/fcvm.2024.1446014/fullIVUSstent implantationcomplex CADangiographymeta-analysis |
| spellingShingle | Anyi Xu Dongying Wang Bangsheng Chen Siyue Song Qiufeng Zhang Zuokun Zhu Min Dai Chenyi Wang Efficacy of IVUS-guided stent implantation in patients with complex CAD: a meta-analysis based on RCTs Frontiers in Cardiovascular Medicine IVUS stent implantation complex CAD angiography meta-analysis |
| title | Efficacy of IVUS-guided stent implantation in patients with complex CAD: a meta-analysis based on RCTs |
| title_full | Efficacy of IVUS-guided stent implantation in patients with complex CAD: a meta-analysis based on RCTs |
| title_fullStr | Efficacy of IVUS-guided stent implantation in patients with complex CAD: a meta-analysis based on RCTs |
| title_full_unstemmed | Efficacy of IVUS-guided stent implantation in patients with complex CAD: a meta-analysis based on RCTs |
| title_short | Efficacy of IVUS-guided stent implantation in patients with complex CAD: a meta-analysis based on RCTs |
| title_sort | efficacy of ivus guided stent implantation in patients with complex cad a meta analysis based on rcts |
| topic | IVUS stent implantation complex CAD angiography meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2024.1446014/full |
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