Impact of malnutrition and associated factors on rifampicin/multi-drug-resistant tuberculosis treatment outcomes among patients treated in alert and St. Peter’s Specialized Hospitals, Addis Ababa, Ethiopia: a retrospective follow-up study
Abstract Objective This study was aimed to assess the impact of malnutrition and associated factors on rifampicin/multi-drug-resistant tuberculosis treatment outcomes among patients treated in Alert and St. Peter’s Specialized Hospitals, Addis Ababa, Ethiopia. Results Our study included 344 RR/MDR-T...
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2025-05-01
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| Online Access: | https://doi.org/10.1186/s13104-025-07268-2 |
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| author | Ekram Mohammed Siraj Tilahun Bizuayehu Demass Ayenew Molla Lakew Lake Yazachew Amogne Mulat Addis Beshaw |
| author_facet | Ekram Mohammed Siraj Tilahun Bizuayehu Demass Ayenew Molla Lakew Lake Yazachew Amogne Mulat Addis Beshaw |
| author_sort | Ekram Mohammed Siraj |
| collection | DOAJ |
| description | Abstract Objective This study was aimed to assess the impact of malnutrition and associated factors on rifampicin/multi-drug-resistant tuberculosis treatment outcomes among patients treated in Alert and St. Peter’s Specialized Hospitals, Addis Ababa, Ethiopia. Results Our study included 344 RR/MDR-TB patients, of which 43.3% were undernourished. The overall unsuccessful treatment outcome was 22.1% (95% CI 0.18, 0.27). Patients with undernutrition were over eight times more likely to develop unsuccessful treatment outcomes [AOR = 8.32 (95% CI 4.48, 15.46)] compared to normal/ overweight individuals. After we computed the binary logistic regression analysis separately for patients with undernutrition and normal/ overweight nutritional status, age, residence, occupation, chest x-ray, anemia, co-morbidities, cigarette smoking, and alcohol drinking were significantly associated with unsuccessful treatment outcomes among undernourished patients, while age, HIV, and smoking were significantly associated with unsuccessful treatment outcomes among patients with normal/overweight individuals. Conclusions In this study, undernutrition had a remarkable impact on unsuccessful treatment outcomes. Therefore, further researches need to be conducted to integrate the management of undernutrition with the DR-TB treatment program. |
| format | Article |
| id | doaj-art-bedf1d72a3c24aaf827731b2529ef5ca |
| institution | Kabale University |
| issn | 1756-0500 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMC |
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| series | BMC Research Notes |
| spelling | doaj-art-bedf1d72a3c24aaf827731b2529ef5ca2025-08-20T03:53:08ZengBMCBMC Research Notes1756-05002025-05-0118111210.1186/s13104-025-07268-2Impact of malnutrition and associated factors on rifampicin/multi-drug-resistant tuberculosis treatment outcomes among patients treated in alert and St. Peter’s Specialized Hospitals, Addis Ababa, Ethiopia: a retrospective follow-up studyEkram Mohammed Siraj0Tilahun Bizuayehu Demass1Ayenew Molla Lakew2Lake Yazachew Amogne3Mulat Addis Beshaw4Department of Internal Medicine, Alert Comprehensive Specialized HospitalDepartment of Internal Medicine, College of Medicine and Health Sciences, University of GondarDepartment of Epidemiology and Biostatistics, Institute of Public Health, College of Medicine and Health Sciences, University of GondarDepartment of Health Systems and Policy, Institute of Public Health, College of Medicine and Health Sciences, University of GondarDepartment of Internal Medicine, College of Medicine and Health Sciences, University of GondarAbstract Objective This study was aimed to assess the impact of malnutrition and associated factors on rifampicin/multi-drug-resistant tuberculosis treatment outcomes among patients treated in Alert and St. Peter’s Specialized Hospitals, Addis Ababa, Ethiopia. Results Our study included 344 RR/MDR-TB patients, of which 43.3% were undernourished. The overall unsuccessful treatment outcome was 22.1% (95% CI 0.18, 0.27). Patients with undernutrition were over eight times more likely to develop unsuccessful treatment outcomes [AOR = 8.32 (95% CI 4.48, 15.46)] compared to normal/ overweight individuals. After we computed the binary logistic regression analysis separately for patients with undernutrition and normal/ overweight nutritional status, age, residence, occupation, chest x-ray, anemia, co-morbidities, cigarette smoking, and alcohol drinking were significantly associated with unsuccessful treatment outcomes among undernourished patients, while age, HIV, and smoking were significantly associated with unsuccessful treatment outcomes among patients with normal/overweight individuals. Conclusions In this study, undernutrition had a remarkable impact on unsuccessful treatment outcomes. Therefore, further researches need to be conducted to integrate the management of undernutrition with the DR-TB treatment program.https://doi.org/10.1186/s13104-025-07268-2MDR/RR-TBMalnutritionTreatment outcomeFactorsEthiopia |
| spellingShingle | Ekram Mohammed Siraj Tilahun Bizuayehu Demass Ayenew Molla Lakew Lake Yazachew Amogne Mulat Addis Beshaw Impact of malnutrition and associated factors on rifampicin/multi-drug-resistant tuberculosis treatment outcomes among patients treated in alert and St. Peter’s Specialized Hospitals, Addis Ababa, Ethiopia: a retrospective follow-up study BMC Research Notes MDR/RR-TB Malnutrition Treatment outcome Factors Ethiopia |
| title | Impact of malnutrition and associated factors on rifampicin/multi-drug-resistant tuberculosis treatment outcomes among patients treated in alert and St. Peter’s Specialized Hospitals, Addis Ababa, Ethiopia: a retrospective follow-up study |
| title_full | Impact of malnutrition and associated factors on rifampicin/multi-drug-resistant tuberculosis treatment outcomes among patients treated in alert and St. Peter’s Specialized Hospitals, Addis Ababa, Ethiopia: a retrospective follow-up study |
| title_fullStr | Impact of malnutrition and associated factors on rifampicin/multi-drug-resistant tuberculosis treatment outcomes among patients treated in alert and St. Peter’s Specialized Hospitals, Addis Ababa, Ethiopia: a retrospective follow-up study |
| title_full_unstemmed | Impact of malnutrition and associated factors on rifampicin/multi-drug-resistant tuberculosis treatment outcomes among patients treated in alert and St. Peter’s Specialized Hospitals, Addis Ababa, Ethiopia: a retrospective follow-up study |
| title_short | Impact of malnutrition and associated factors on rifampicin/multi-drug-resistant tuberculosis treatment outcomes among patients treated in alert and St. Peter’s Specialized Hospitals, Addis Ababa, Ethiopia: a retrospective follow-up study |
| title_sort | impact of malnutrition and associated factors on rifampicin multi drug resistant tuberculosis treatment outcomes among patients treated in alert and st peter s specialized hospitals addis ababa ethiopia a retrospective follow up study |
| topic | MDR/RR-TB Malnutrition Treatment outcome Factors Ethiopia |
| url | https://doi.org/10.1186/s13104-025-07268-2 |
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