Advances in the Prevention of Cervical Cancer by Anti‐Human Papillomavirus Agents
ABSTRACT Background Cervical cancer remains a major global health threat for women, primarily driven by human papillomavirus (HPV) infection. While HPV vaccination serves as the cornerstone of prevention, disparities in vaccine accessibility persist across low‐income countries. Secondary prevention...
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| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2025-04-01
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| Series: | Cancer Medicine |
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| Online Access: | https://doi.org/10.1002/cam4.70847 |
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| author | Hangdi Chen Kai Guo Zhihao Bai Liuyi Lu Bin Liu Jiali Zhang Meiyin Zhong Changfen Xu Wanghuan Chen Aiwu Huang Yuemin Ding |
| author_facet | Hangdi Chen Kai Guo Zhihao Bai Liuyi Lu Bin Liu Jiali Zhang Meiyin Zhong Changfen Xu Wanghuan Chen Aiwu Huang Yuemin Ding |
| author_sort | Hangdi Chen |
| collection | DOAJ |
| description | ABSTRACT Background Cervical cancer remains a major global health threat for women, primarily driven by human papillomavirus (HPV) infection. While HPV vaccination serves as the cornerstone of prevention, disparities in vaccine accessibility persist across low‐income countries. Secondary prevention through screening faces challenges in public engagement, often leading to late‐stage diagnoses. Recent advancements in novel anti‐HPV drugs offer expanded opportunities for cervical cancer management. Aim This review examines emerging anti‐HPV therapeutics to provide insights into innovative strategies for cervical cancer prevention and treatment. Methods We conducted a systematic analysis of published studies investigating anti‐HPV agents, focusing on their molecular mechanisms and clinical efficacy in cervical cancer prevention. Results & Conclusions Multiple promising anti‐HPV agents have been identified, including 3‐hydroxyphthalic anhydride‐modified bovine β‐lactoglobulin (3HP‐β‐LG), carrageenan, defensins, and 25‐hydroxycholesterol (25HC). These compounds exert antiviral effects through distinct mechanisms: 3HP‐β‐LG competitively inhibits viral attachment, carrageenan blocks HPV entry via heparan sulfate mimicry, defensins inhibit the dissociation of viral capsid, and 25HC activates cholesterol‐mediated antiviral pathways. They have demonstrated strong inhibitory effects on HPV infection, making them novel therapeutic candidates for the prevention and treatment of cervical cancer. |
| format | Article |
| id | doaj-art-bed65941094742309e34be5eeebd0f83 |
| institution | Kabale University |
| issn | 2045-7634 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj-art-bed65941094742309e34be5eeebd0f832025-08-20T03:53:07ZengWileyCancer Medicine2045-76342025-04-01147n/an/a10.1002/cam4.70847Advances in the Prevention of Cervical Cancer by Anti‐Human Papillomavirus AgentsHangdi Chen0Kai Guo1Zhihao Bai2Liuyi Lu3Bin Liu4Jiali Zhang5Meiyin Zhong6Changfen Xu7Wanghuan Chen8Aiwu Huang9Yuemin Ding10Department of Clinical Medicine School of Medicine, Hangzhou City University Hangzhou ChinaDepartment of Clinical Medicine School of Medicine, Hangzhou City University Hangzhou ChinaDepartment of Clinical Medicine School of Medicine, Hangzhou City University Hangzhou ChinaDepartment of Clinical Medicine School of Medicine, Hangzhou City University Hangzhou ChinaDepartment of Clinical Medicine School of Medicine, Hangzhou City University Hangzhou ChinaDepartment of Clinical Medicine School of Medicine, Hangzhou City University Hangzhou ChinaDepartment of Clinical Medicine School of Medicine, Hangzhou City University Hangzhou ChinaDepartment of Obstetrics and Gynecology Hangzhou Lin'an District Hospital of Traditional Chinese Medicine, Affiliated Hospital of Hangzhou City University Hangzhou ChinaDepartment of Obstetrics and Gynecology Hangzhou Lin'an District Hospital of Traditional Chinese Medicine, Affiliated Hospital of Hangzhou City University Hangzhou ChinaDepartment of Obstetrics and Gynecology Hangzhou Lin'an District Hospital of Traditional Chinese Medicine, Affiliated Hospital of Hangzhou City University Hangzhou ChinaDepartment of Clinical Medicine School of Medicine, Hangzhou City University Hangzhou ChinaABSTRACT Background Cervical cancer remains a major global health threat for women, primarily driven by human papillomavirus (HPV) infection. While HPV vaccination serves as the cornerstone of prevention, disparities in vaccine accessibility persist across low‐income countries. Secondary prevention through screening faces challenges in public engagement, often leading to late‐stage diagnoses. Recent advancements in novel anti‐HPV drugs offer expanded opportunities for cervical cancer management. Aim This review examines emerging anti‐HPV therapeutics to provide insights into innovative strategies for cervical cancer prevention and treatment. Methods We conducted a systematic analysis of published studies investigating anti‐HPV agents, focusing on their molecular mechanisms and clinical efficacy in cervical cancer prevention. Results & Conclusions Multiple promising anti‐HPV agents have been identified, including 3‐hydroxyphthalic anhydride‐modified bovine β‐lactoglobulin (3HP‐β‐LG), carrageenan, defensins, and 25‐hydroxycholesterol (25HC). These compounds exert antiviral effects through distinct mechanisms: 3HP‐β‐LG competitively inhibits viral attachment, carrageenan blocks HPV entry via heparan sulfate mimicry, defensins inhibit the dissociation of viral capsid, and 25HC activates cholesterol‐mediated antiviral pathways. They have demonstrated strong inhibitory effects on HPV infection, making them novel therapeutic candidates for the prevention and treatment of cervical cancer.https://doi.org/10.1002/cam4.70847anti‐HPV agentantiviruscervical cancerHPVprevention and treatment |
| spellingShingle | Hangdi Chen Kai Guo Zhihao Bai Liuyi Lu Bin Liu Jiali Zhang Meiyin Zhong Changfen Xu Wanghuan Chen Aiwu Huang Yuemin Ding Advances in the Prevention of Cervical Cancer by Anti‐Human Papillomavirus Agents Cancer Medicine anti‐HPV agent antivirus cervical cancer HPV prevention and treatment |
| title | Advances in the Prevention of Cervical Cancer by Anti‐Human Papillomavirus Agents |
| title_full | Advances in the Prevention of Cervical Cancer by Anti‐Human Papillomavirus Agents |
| title_fullStr | Advances in the Prevention of Cervical Cancer by Anti‐Human Papillomavirus Agents |
| title_full_unstemmed | Advances in the Prevention of Cervical Cancer by Anti‐Human Papillomavirus Agents |
| title_short | Advances in the Prevention of Cervical Cancer by Anti‐Human Papillomavirus Agents |
| title_sort | advances in the prevention of cervical cancer by anti human papillomavirus agents |
| topic | anti‐HPV agent antivirus cervical cancer HPV prevention and treatment |
| url | https://doi.org/10.1002/cam4.70847 |
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