Advances in the Prevention of Cervical Cancer by Anti‐Human Papillomavirus Agents

Advances in the Prevention of Cervical Cancer by Anti‐Human Papillomavirus Agents

ABSTRACT Background Cervical cancer remains a major global health threat for women, primarily driven by human papillomavirus (HPV) infection. While HPV vaccination serves as the cornerstone of prevention, disparities in vaccine accessibility persist across low‐income countries. Secondary prevention...

Full description

Saved in:
Bibliographic Details
Main Authors: Hangdi Chen, Kai Guo, Zhihao Bai, Liuyi Lu, Bin Liu, Jiali Zhang, Meiyin Zhong, Changfen Xu, Wanghuan Chen, Aiwu Huang, Yuemin Ding
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:Cancer Medicine
Subjects:
anti‐HPV agent
antivirus
cervical cancer
HPV
prevention and treatment
Online Access:https://doi.org/10.1002/cam4.70847
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:ABSTRACT Background Cervical cancer remains a major global health threat for women, primarily driven by human papillomavirus (HPV) infection. While HPV vaccination serves as the cornerstone of prevention, disparities in vaccine accessibility persist across low‐income countries. Secondary prevention through screening faces challenges in public engagement, often leading to late‐stage diagnoses. Recent advancements in novel anti‐HPV drugs offer expanded opportunities for cervical cancer management. Aim This review examines emerging anti‐HPV therapeutics to provide insights into innovative strategies for cervical cancer prevention and treatment. Methods We conducted a systematic analysis of published studies investigating anti‐HPV agents, focusing on their molecular mechanisms and clinical efficacy in cervical cancer prevention. Results & Conclusions Multiple promising anti‐HPV agents have been identified, including 3‐hydroxyphthalic anhydride‐modified bovine β‐lactoglobulin (3HP‐β‐LG), carrageenan, defensins, and 25‐hydroxycholesterol (25HC). These compounds exert antiviral effects through distinct mechanisms: 3HP‐β‐LG competitively inhibits viral attachment, carrageenan blocks HPV entry via heparan sulfate mimicry, defensins inhibit the dissociation of viral capsid, and 25HC activates cholesterol‐mediated antiviral pathways. They have demonstrated strong inhibitory effects on HPV infection, making them novel therapeutic candidates for the prevention and treatment of cervical cancer.
ISSN:2045-7634

Similar Items