Development of a standardized monoclonal antibody to the inner lipoyl domain of PDC-E2 as a potential international AMA reference

Development of a standardized monoclonal antibody to the inner lipoyl domain of PDC-E2 as a potential international AMA reference

The detection of antimitochondrial antibodies (AMA) is the specific diagnostic marker for primary biliary cholangitis. Indeed, it is the most specific autoantibody in clinical autoimmunity, with a high titer directed response to the inner lipoyl domain of PDC-E2. The current international reference...

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Bibliographic Details
Main Authors: Zhuye Qin, Fangming Cheng, Mingming Zhang, Ruonan Qian, Hong Chen, Yaqin Zhao, Youtao Zhang, Yaping Dai, Chaochao Tang, Peng Jiang, Xiaoli Hua, Shen Li, Bing Zheng, Pin Yu, Xingjuan Shi, Suraj Timilsina, M. Eric Gershwin, Xiangdong Liu, Chungen Qian, Fang Qiu
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Journal of Translational Autoimmunity
Subjects:
Primary biliary cholangitis
AMA
Chimeric antibody
PDC-E2
Inner lipoyl domain
Online Access:http://www.sciencedirect.com/science/article/pii/S2589909024000327
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