Formation of 4-hydroxynonenal and further aldehydic mediators of inflammation during bromotrichlorornethane treatment of rat liver cells
Bromotrichloromethane (CBrCl3) treatment is a model for studies on molecular mechanisms of haloalkane toxicity with some advantages compared with CCl4 treatment. The formation of 4-hydroxynonenal and similar aldehydic products of lipid peroxidation, which play a role as mediators of inflammatory pro...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
1993-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S0962935193000031 |
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| _version_ | 1849685668569022464 |
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| author | Olaf Sommerburg Tilman Grune Sabine Klee Fritz R. Ungemach Werner G. Siems |
| author_facet | Olaf Sommerburg Tilman Grune Sabine Klee Fritz R. Ungemach Werner G. Siems |
| author_sort | Olaf Sommerburg |
| collection | DOAJ |
| description | Bromotrichloromethane (CBrCl3) treatment is a model for studies on molecular mechanisms of haloalkane toxicity with some advantages compared with CCl4 treatment. The formation of 4-hydroxynonenal and similar aldehydic products of lipid peroxidation, which play a role as mediators of inflammatory processes, was clearly demonstrated in rat hepatocytes treated with CBrCl3. It may be assumed that haloalkane toxicity is connected with the biological effects of those inflammation mediatory aldehydic compounds. |
| format | Article |
| id | doaj-art-bed35d7ba4174e88b3cc3fae4640d107 |
| institution | DOAJ |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1993-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-bed35d7ba4174e88b3cc3fae4640d1072025-08-20T03:23:02ZengWileyMediators of Inflammation0962-93511466-18611993-01-0121273110.1155/S0962935193000031Formation of 4-hydroxynonenal and further aldehydic mediators of inflammation during bromotrichlorornethane treatment of rat liver cellsOlaf Sommerburg0Tilman Grune1Sabine Klee2Fritz R. Ungemach3Werner G. Siems4Institute of Biochemistry, Medical Faculty (Charité), Humboldt University Berlin, Hessische Str. 3-4, Berlin D(O)-1040, GermanyInstitute of Biochemistry, Medical Faculty (Charité), Humboldt University Berlin, Hessische Str. 3-4, Berlin D(O)-1040, Germanylnstitute of Veterinary Pharmacology and Toxicology, Free University Berlin, Koserstr., Berlin 33 D-1000, Germanylnstitute of Veterinary Pharmacology and Toxicology, Free University Berlin, Koserstr., Berlin 33 D-1000, GermanyHerzog-Julius-Hospital, Kurhausstr, 13–17, Bad Harzburg D-3388, GermanyBromotrichloromethane (CBrCl3) treatment is a model for studies on molecular mechanisms of haloalkane toxicity with some advantages compared with CCl4 treatment. The formation of 4-hydroxynonenal and similar aldehydic products of lipid peroxidation, which play a role as mediators of inflammatory processes, was clearly demonstrated in rat hepatocytes treated with CBrCl3. It may be assumed that haloalkane toxicity is connected with the biological effects of those inflammation mediatory aldehydic compounds.http://dx.doi.org/10.1155/S0962935193000031 |
| spellingShingle | Olaf Sommerburg Tilman Grune Sabine Klee Fritz R. Ungemach Werner G. Siems Formation of 4-hydroxynonenal and further aldehydic mediators of inflammation during bromotrichlorornethane treatment of rat liver cells Mediators of Inflammation |
| title | Formation of 4-hydroxynonenal and further aldehydic mediators of inflammation during bromotrichlorornethane treatment of rat liver cells |
| title_full | Formation of 4-hydroxynonenal and further aldehydic mediators of inflammation during bromotrichlorornethane treatment of rat liver cells |
| title_fullStr | Formation of 4-hydroxynonenal and further aldehydic mediators of inflammation during bromotrichlorornethane treatment of rat liver cells |
| title_full_unstemmed | Formation of 4-hydroxynonenal and further aldehydic mediators of inflammation during bromotrichlorornethane treatment of rat liver cells |
| title_short | Formation of 4-hydroxynonenal and further aldehydic mediators of inflammation during bromotrichlorornethane treatment of rat liver cells |
| title_sort | formation of 4 hydroxynonenal and further aldehydic mediators of inflammation during bromotrichlorornethane treatment of rat liver cells |
| url | http://dx.doi.org/10.1155/S0962935193000031 |
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