Assessment of Early Cognitive Impairment in Patients with Clinically Isolated Syndromes and Multiple Sclerosis
Objective. The aim of our study was to investigate the frequency and pattern of cognitive impairment in patients with clinically isolated syndromes and definite diagnosis of multiple sclerosis within the last 2 years. Methods. We assessed the cognitive status of 46 patients aged 18–49 years with cli...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2014-01-01
|
| Series: | Behavioural Neurology |
| Online Access: | http://dx.doi.org/10.1155/2014/637694 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832560828355706880 |
|---|---|
| author | Leyla Baysal Kıraç Özgül Ekmekçi Nur Yüceyar Ayşe Sağduyu Kocaman |
| author_facet | Leyla Baysal Kıraç Özgül Ekmekçi Nur Yüceyar Ayşe Sağduyu Kocaman |
| author_sort | Leyla Baysal Kıraç |
| collection | DOAJ |
| description | Objective. The aim of our study was to investigate the frequency and pattern of cognitive impairment in patients with clinically isolated syndromes and definite diagnosis of multiple sclerosis within the last 2 years. Methods. We assessed the cognitive status of 46 patients aged 18–49 years with clinically isolated syndromes or definite diagnosis of multiple sclerosis who have onset of their symptoms within the last 2 years. Patients were matched with 40 healthy participants for age, sex, and educational level. Neuropsychological assessment was performed by stroop test, paced auditory serial addition test (PASAT), controlled oral word association test (COWAT), clock drawing test, trail making test (TMT), faces symbol test (FST). Hamilton Depression Scale and Modified Fatigue Impact Scale were used to quantify the severity of any depression and fatigue the subjects might suffer. Results. 19.6% of early MS/CIS group failed at 4 and more tests and had significant cognitive impairment focused on attention, executive functions, memory, and learning. No significant relationship was found between cognitive impairment and disability and fatigue scores. Discussion. Cognitive impairment can be present from the earliest stage of multiple sclerosis. It should be considered among the main manifestations of MS even in the earliest stages of the disease. |
| format | Article |
| id | doaj-art-bed2aea695c84433823f523d9de1a0a2 |
| institution | Kabale University |
| issn | 0953-4180 1875-8584 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Behavioural Neurology |
| spelling | doaj-art-bed2aea695c84433823f523d9de1a0a22025-02-03T01:26:40ZengWileyBehavioural Neurology0953-41801875-85842014-01-01201410.1155/2014/637694637694Assessment of Early Cognitive Impairment in Patients with Clinically Isolated Syndromes and Multiple SclerosisLeyla Baysal Kıraç0Özgül Ekmekçi1Nur Yüceyar2Ayşe Sağduyu Kocaman3Neurology Department, School of Medicine, Ege University, 35100 Bornova, İzmir, TurkeyNeurology Department, School of Medicine, Ege University, 35100 Bornova, İzmir, TurkeyNeurology Department, School of Medicine, Ege University, 35100 Bornova, İzmir, TurkeyNeurology Department, Acibadem University School of Medicine, TurkeyObjective. The aim of our study was to investigate the frequency and pattern of cognitive impairment in patients with clinically isolated syndromes and definite diagnosis of multiple sclerosis within the last 2 years. Methods. We assessed the cognitive status of 46 patients aged 18–49 years with clinically isolated syndromes or definite diagnosis of multiple sclerosis who have onset of their symptoms within the last 2 years. Patients were matched with 40 healthy participants for age, sex, and educational level. Neuropsychological assessment was performed by stroop test, paced auditory serial addition test (PASAT), controlled oral word association test (COWAT), clock drawing test, trail making test (TMT), faces symbol test (FST). Hamilton Depression Scale and Modified Fatigue Impact Scale were used to quantify the severity of any depression and fatigue the subjects might suffer. Results. 19.6% of early MS/CIS group failed at 4 and more tests and had significant cognitive impairment focused on attention, executive functions, memory, and learning. No significant relationship was found between cognitive impairment and disability and fatigue scores. Discussion. Cognitive impairment can be present from the earliest stage of multiple sclerosis. It should be considered among the main manifestations of MS even in the earliest stages of the disease.http://dx.doi.org/10.1155/2014/637694 |
| spellingShingle | Leyla Baysal Kıraç Özgül Ekmekçi Nur Yüceyar Ayşe Sağduyu Kocaman Assessment of Early Cognitive Impairment in Patients with Clinically Isolated Syndromes and Multiple Sclerosis Behavioural Neurology |
| title | Assessment of Early Cognitive Impairment in Patients with Clinically Isolated Syndromes and Multiple Sclerosis |
| title_full | Assessment of Early Cognitive Impairment in Patients with Clinically Isolated Syndromes and Multiple Sclerosis |
| title_fullStr | Assessment of Early Cognitive Impairment in Patients with Clinically Isolated Syndromes and Multiple Sclerosis |
| title_full_unstemmed | Assessment of Early Cognitive Impairment in Patients with Clinically Isolated Syndromes and Multiple Sclerosis |
| title_short | Assessment of Early Cognitive Impairment in Patients with Clinically Isolated Syndromes and Multiple Sclerosis |
| title_sort | assessment of early cognitive impairment in patients with clinically isolated syndromes and multiple sclerosis |
| url | http://dx.doi.org/10.1155/2014/637694 |
| work_keys_str_mv | AT leylabaysalkırac assessmentofearlycognitiveimpairmentinpatientswithclinicallyisolatedsyndromesandmultiplesclerosis AT ozgulekmekci assessmentofearlycognitiveimpairmentinpatientswithclinicallyisolatedsyndromesandmultiplesclerosis AT nuryuceyar assessmentofearlycognitiveimpairmentinpatientswithclinicallyisolatedsyndromesandmultiplesclerosis AT aysesagduyukocaman assessmentofearlycognitiveimpairmentinpatientswithclinicallyisolatedsyndromesandmultiplesclerosis |