Curcumin-loaded nanoparticles for renal ischemia-reperfusion injuries: Triple-play of redox homeostasis accommodation, lipid metabolism regulation, and nuclear magnetic tracing
Renal ischemia reperfusion (RI/R) injury is a significant pathological process that occurs in acute kidney injury (AKI), and is associated with high mortality rates and poor prognoses. It is therefore essential to explore new therapeutic strategies to enhance treatment outcomes for this condition. C...
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Elsevier
2025-08-01
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| author | Ning Wang Xuna Xue Zhibo Zhang Meng Gao Lianhong Yin Lina Xu Xuerong Zhao Jinyong Peng |
| author_facet | Ning Wang Xuna Xue Zhibo Zhang Meng Gao Lianhong Yin Lina Xu Xuerong Zhao Jinyong Peng |
| author_sort | Ning Wang |
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| description | Renal ischemia reperfusion (RI/R) injury is a significant pathological process that occurs in acute kidney injury (AKI), and is associated with high mortality rates and poor prognoses. It is therefore essential to explore new therapeutic strategies to enhance treatment outcomes for this condition. Curcumin (Cur), a natural bioactive polyphenolic compound, possesses anti-inflammatory and antioxidant properties. However, its clinical application is limited by poor water solubility and low bioavailability. To overcome these challenges, two amphiphilic molecules were synthesized, PEG-DTPA-DA (PD) and Gd-DTPA-N10 (G). By self-assembling PD and G while loading Cur, a nanoparticle was successfully prepared, PDG@Cur, which served three functions: regulation of lipid metabolism, maintenance of redox homeostasis, and function as a nuclear magnetic resonance (NMR) tracer. In vitro and in vivo experiments indicated that PDG@Cur exhibited excellent stability, effectively quenching reactive oxygen species (ROS), and demonstrating robust capabilities for NMR imaging. Furthermore, PDG@Cur mitigated renal tissue damage due to its potent antioxidant properties and ability to regulate lipid metabolism. Molecular mechanism studies revealed that Cur directly bound to FABP4, and that PDG@Cur targeted the FABP4/PPARγ pathway to exert pharmacological effects against RI/R injuries. In conclusion, this study may provide a novel therapeutic strategy for the treatment of RI/R injuries. |
| format | Article |
| id | doaj-art-bed0d65724e342a19f9751706f105aa2 |
| institution | Kabale University |
| issn | 2590-0064 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Elsevier |
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| spelling | doaj-art-bed0d65724e342a19f9751706f105aa22025-08-20T03:30:43ZengElsevierMaterials Today Bio2590-00642025-08-013310198610.1016/j.mtbio.2025.101986Curcumin-loaded nanoparticles for renal ischemia-reperfusion injuries: Triple-play of redox homeostasis accommodation, lipid metabolism regulation, and nuclear magnetic tracingNing Wang0Xuna Xue1Zhibo Zhang2Meng Gao3Lianhong Yin4Lina Xu5Xuerong Zhao6Jinyong Peng7College of Pharmacy, Dalian Medical University, Western 9 Lvshunnan Road, Dalian, 116044, ChinaCollege of Pharmacy, Dalian Medical University, Western 9 Lvshunnan Road, Dalian, 116044, ChinaCollege of Pharmacy, Dalian Medical University, Western 9 Lvshunnan Road, Dalian, 116044, ChinaCollege of Pharmacy, Dalian Medical University, Western 9 Lvshunnan Road, Dalian, 116044, ChinaCollege of Pharmacy, Dalian Medical University, Western 9 Lvshunnan Road, Dalian, 116044, ChinaCollege of Pharmacy, Dalian Medical University, Western 9 Lvshunnan Road, Dalian, 116044, ChinaCollege of Pharmacy, Dalian Medical University, Western 9 Lvshunnan Road, Dalian, 116044, China; Corresponding author.College of Pharmacy, Dalian Medical University, Western 9 Lvshunnan Road, Dalian, 116044, China; College of Pharmacy, Hubei University of Chinese Medicine, Wuhan, 430065, China; Hubei Shizhen Laboratory, Wuhan, 430065, China; Corresponding author. College of Pharmacy, Dalian Medical University, Western 9 Lvshunnan Road, Dalian, 116044, China.Renal ischemia reperfusion (RI/R) injury is a significant pathological process that occurs in acute kidney injury (AKI), and is associated with high mortality rates and poor prognoses. It is therefore essential to explore new therapeutic strategies to enhance treatment outcomes for this condition. Curcumin (Cur), a natural bioactive polyphenolic compound, possesses anti-inflammatory and antioxidant properties. However, its clinical application is limited by poor water solubility and low bioavailability. To overcome these challenges, two amphiphilic molecules were synthesized, PEG-DTPA-DA (PD) and Gd-DTPA-N10 (G). By self-assembling PD and G while loading Cur, a nanoparticle was successfully prepared, PDG@Cur, which served three functions: regulation of lipid metabolism, maintenance of redox homeostasis, and function as a nuclear magnetic resonance (NMR) tracer. In vitro and in vivo experiments indicated that PDG@Cur exhibited excellent stability, effectively quenching reactive oxygen species (ROS), and demonstrating robust capabilities for NMR imaging. Furthermore, PDG@Cur mitigated renal tissue damage due to its potent antioxidant properties and ability to regulate lipid metabolism. Molecular mechanism studies revealed that Cur directly bound to FABP4, and that PDG@Cur targeted the FABP4/PPARγ pathway to exert pharmacological effects against RI/R injuries. In conclusion, this study may provide a novel therapeutic strategy for the treatment of RI/R injuries.http://www.sciencedirect.com/science/article/pii/S2590006425005563NanoparticlesCurcuminRenal ischemia reperfusion injuryFABP4/PPARγLipid metabolism |
| spellingShingle | Ning Wang Xuna Xue Zhibo Zhang Meng Gao Lianhong Yin Lina Xu Xuerong Zhao Jinyong Peng Curcumin-loaded nanoparticles for renal ischemia-reperfusion injuries: Triple-play of redox homeostasis accommodation, lipid metabolism regulation, and nuclear magnetic tracing Materials Today Bio Nanoparticles Curcumin Renal ischemia reperfusion injury FABP4/PPARγ Lipid metabolism |
| title | Curcumin-loaded nanoparticles for renal ischemia-reperfusion injuries: Triple-play of redox homeostasis accommodation, lipid metabolism regulation, and nuclear magnetic tracing |
| title_full | Curcumin-loaded nanoparticles for renal ischemia-reperfusion injuries: Triple-play of redox homeostasis accommodation, lipid metabolism regulation, and nuclear magnetic tracing |
| title_fullStr | Curcumin-loaded nanoparticles for renal ischemia-reperfusion injuries: Triple-play of redox homeostasis accommodation, lipid metabolism regulation, and nuclear magnetic tracing |
| title_full_unstemmed | Curcumin-loaded nanoparticles for renal ischemia-reperfusion injuries: Triple-play of redox homeostasis accommodation, lipid metabolism regulation, and nuclear magnetic tracing |
| title_short | Curcumin-loaded nanoparticles for renal ischemia-reperfusion injuries: Triple-play of redox homeostasis accommodation, lipid metabolism regulation, and nuclear magnetic tracing |
| title_sort | curcumin loaded nanoparticles for renal ischemia reperfusion injuries triple play of redox homeostasis accommodation lipid metabolism regulation and nuclear magnetic tracing |
| topic | Nanoparticles Curcumin Renal ischemia reperfusion injury FABP4/PPARγ Lipid metabolism |
| url | http://www.sciencedirect.com/science/article/pii/S2590006425005563 |
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