Synthesis and biological activity of 5-acetyl- and 5-hydroxyalkyl1,3-dioxane derivatives
Objectives. To synthesize derivatives of 5-acetyl- and 5-hydroxyalkyl-1,3-dioxanes and evaluate their effect on platelet aggregation and plasma hemostasis.Methods. To determine the qualitative and quantitative composition of the reaction masses, gas chromatography-, chromate mass spectrometry-, and...
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| Format: | Article |
| Language: | Russian |
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MIREA - Russian Technological University
2023-10-01
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| Series: | Тонкие химические технологии |
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| Online Access: | https://www.finechem-mirea.ru/jour/article/view/1992 |
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| author | A. I. Musin Yu. G. Borisova Sh. Sh. Dzhumaev N. S. Khusnutdinova G. Z. Raskil’dina R. M. Sultanova S. S. Zlotskii |
| author_facet | A. I. Musin Yu. G. Borisova Sh. Sh. Dzhumaev N. S. Khusnutdinova G. Z. Raskil’dina R. M. Sultanova S. S. Zlotskii |
| author_sort | A. I. Musin |
| collection | DOAJ |
| description | Objectives. To synthesize derivatives of 5-acetyl- and 5-hydroxyalkyl-1,3-dioxanes and evaluate their effect on platelet aggregation and plasma hemostasis.Methods. To determine the qualitative and quantitative composition of the reaction masses, gas chromatography-, chromate mass spectrometry-, and 1H and 13C nuclear magnetic resonance spectrometry methods were used.Results. Derivatives of 5-acetyl- and 5-hydroxyalkyl-1,3-dioxanes were obtained under thermal heating conditions in order to evaluate their effect on platelet aggregation and plasma hemostasis.Conclusions. Derivatives of 5-acetyl- and 5-hydroxyalkyl-1,3-dioxanes were synthesized in high yields. Their effect on platelet aggregation and plasma hemostasis was established. |
| format | Article |
| id | doaj-art-bece0f0fed29426eb3cc6a267bff54c8 |
| institution | Kabale University |
| issn | 2410-6593 2686-7575 |
| language | Russian |
| publishDate | 2023-10-01 |
| publisher | MIREA - Russian Technological University |
| record_format | Article |
| series | Тонкие химические технологии |
| spelling | doaj-art-bece0f0fed29426eb3cc6a267bff54c82025-08-20T03:56:32ZrusMIREA - Russian Technological UniversityТонкие химические технологии2410-65932686-75752023-10-0118438139110.32362/2410-6593-2023-18-4-381-3911728Synthesis and biological activity of 5-acetyl- and 5-hydroxyalkyl1,3-dioxane derivativesA. I. Musin0Yu. G. Borisova1Sh. Sh. Dzhumaev2N. S. Khusnutdinova3G. Z. Raskil’dina4R. M. Sultanova5S. S. Zlotskii6Ufa State Petroleum Technological UniversityUfa State Petroleum Technological UniversityUfa State Petroleum Technological UniversityUfa State Petroleum Technological University; Bashkir State Medical UniversityUfa State Petroleum Technological UniversityUfa State Petroleum Technological UniversityUfa State Petroleum Technological UniversityObjectives. To synthesize derivatives of 5-acetyl- and 5-hydroxyalkyl-1,3-dioxanes and evaluate their effect on platelet aggregation and plasma hemostasis.Methods. To determine the qualitative and quantitative composition of the reaction masses, gas chromatography-, chromate mass spectrometry-, and 1H and 13C nuclear magnetic resonance spectrometry methods were used.Results. Derivatives of 5-acetyl- and 5-hydroxyalkyl-1,3-dioxanes were obtained under thermal heating conditions in order to evaluate their effect on platelet aggregation and plasma hemostasis.Conclusions. Derivatives of 5-acetyl- and 5-hydroxyalkyl-1,3-dioxanes were synthesized in high yields. Their effect on platelet aggregation and plasma hemostasis was established.https://www.finechem-mirea.ru/jour/article/view/19925-acyl-1,3-dioxanealkylationethersisoniazid2,4-dinitrophenyl hydrazine |
| spellingShingle | A. I. Musin Yu. G. Borisova Sh. Sh. Dzhumaev N. S. Khusnutdinova G. Z. Raskil’dina R. M. Sultanova S. S. Zlotskii Synthesis and biological activity of 5-acetyl- and 5-hydroxyalkyl1,3-dioxane derivatives Тонкие химические технологии 5-acyl-1,3-dioxane alkylation ethers isoniazid 2,4-dinitrophenyl hydrazine |
| title | Synthesis and biological activity of 5-acetyl- and 5-hydroxyalkyl1,3-dioxane derivatives |
| title_full | Synthesis and biological activity of 5-acetyl- and 5-hydroxyalkyl1,3-dioxane derivatives |
| title_fullStr | Synthesis and biological activity of 5-acetyl- and 5-hydroxyalkyl1,3-dioxane derivatives |
| title_full_unstemmed | Synthesis and biological activity of 5-acetyl- and 5-hydroxyalkyl1,3-dioxane derivatives |
| title_short | Synthesis and biological activity of 5-acetyl- and 5-hydroxyalkyl1,3-dioxane derivatives |
| title_sort | synthesis and biological activity of 5 acetyl and 5 hydroxyalkyl1 3 dioxane derivatives |
| topic | 5-acyl-1,3-dioxane alkylation ethers isoniazid 2,4-dinitrophenyl hydrazine |
| url | https://www.finechem-mirea.ru/jour/article/view/1992 |
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