Effect of cytotoxic CD8+ T-cells secretory proteins on hypoxic pancreatic cancer cells.

Effect of cytotoxic CD8+ T-cells secretory proteins on hypoxic pancreatic cancer cells.

<h4>Background</h4>Hypoxia in tumor cells is linked to increased drug resistance and more aggressive behavior. In pancreatic cancer, the tumor microenvironment is notably hypoxic and exhibits strong immunosuppressive properties. Given that immunotherapy is now approved for pancreatic can...

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Bibliographic Details
Main Authors: Eiman Abdo, Mohammad A Ismail, Sabal Al Hadidi, Mairvat Al-Mrahleh, Tareq Saleh, Malik Zihlif, Nidaa A Ababneh
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0311615
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