Research progress on immune mechanism and control strategy of dsRNA impurities in mRNA vaccine

Research progress on immune mechanism and control strategy of dsRNA impurities in mRNA vaccine

Introduction Double-stranded RNA (dsRNA) is a key impurity of mRNA vaccines prepared by in vitro transcription (IVT) and is primarily transcribed by T7 RNA polymerase. It can trigger innate immunity and induce a series of side effects that may influence the safety of mRNA vaccines.Areas covered This...

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Bibliographic Details
Main Authors: Xinjun Liu, Chaoying Hu, Qian He, Yu Bai, Xuanxuan Zhang, Zhihao Fu, Xiao Ma, Miao Xu, Zhenglun Liang, Qunying Mao
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Expert Review of Vaccines
Subjects:
dsRNA
mRNA
mechanisms
innate immunity
impurities control
Online Access:https://www.tandfonline.com/doi/10.1080/14760584.2025.2510335
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