Platelet aggregation activity and beta-adrenoblocker therapy in patients with dilated cardiomyopathy
Aim. To investigate the specifics of ischemic and idiopathic dilated cardiomyopathy (DCMP), platelet aggregation activity, and the reaction of the latter to the beta-adrenoblocker (β-AB) therapy with atenolol or bisoprolol. Results. In DCMP patients, a significant increase in velocity and maximal am...
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| Format: | Article |
| Language: | Russian |
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«SILICEA-POLIGRAF» LLC
2012-02-01
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| Series: | Кардиоваскулярная терапия и профилактика |
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| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/1700 |
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| author | P. N. Isakhanova Yu. N. Ziyaev Kh. A. Mamatkulov M. Kh. Nazarova Sh. I. Makhamatova |
| author_facet | P. N. Isakhanova Yu. N. Ziyaev Kh. A. Mamatkulov M. Kh. Nazarova Sh. I. Makhamatova |
| author_sort | P. N. Isakhanova |
| collection | DOAJ |
| description | Aim. To investigate the specifics of ischemic and idiopathic dilated cardiomyopathy (DCMP), platelet aggregation activity, and the reaction of the latter to the beta-adrenoblocker (β-AB) therapy with atenolol or bisoprolol. Results. In DCMP patients, a significant increase in velocity and maximal amplitude of ADP-induced platelet aggregation, as well as a significant reduction in the time to the maximal aggregation amplitude, was observed. In both therapy groups, all parameters of platelet aggregation activity were significantly higher in ischemic vs. idiopathic DCMP patients. Long-term bisoprolol therapy provided a more manifested antiaggregant effect of the basis treatment, compared to atenolol therapy. Conclusion. DCMP patients, especially ones with ischemic DCMP, demonstrated an increase in platelet aggregation activity. Long-term bisoprolol therapy facilitated a more pronounced anti-aggregant effect of the basis treatment, compared to atenolol treatment. |
| format | Article |
| id | doaj-art-bec02b325a21469bb4c45c9a0fa868c0 |
| institution | DOAJ |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| publishDate | 2012-02-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj-art-bec02b325a21469bb4c45c9a0fa868c02025-08-20T02:59:52Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252012-02-01111596210.15829/1728-8800-2012-1-59-621418Platelet aggregation activity and beta-adrenoblocker therapy in patients with dilated cardiomyopathyP. N. Isakhanova0Yu. N. Ziyaev1Kh. A. Mamatkulov2M. Kh. Nazarova3Sh. I. Makhamatova4Republican Research Centre for Emergency Care, TashkentRepublican Research Centre for Emergency Care, TashkentRepublican Research Centre for Emergency Care, TashkentRepublican Research Centre for Emergency Care, TashkentRepublican Research Centre for Emergency Care, TashkentAim. To investigate the specifics of ischemic and idiopathic dilated cardiomyopathy (DCMP), platelet aggregation activity, and the reaction of the latter to the beta-adrenoblocker (β-AB) therapy with atenolol or bisoprolol. Results. In DCMP patients, a significant increase in velocity and maximal amplitude of ADP-induced platelet aggregation, as well as a significant reduction in the time to the maximal aggregation amplitude, was observed. In both therapy groups, all parameters of platelet aggregation activity were significantly higher in ischemic vs. idiopathic DCMP patients. Long-term bisoprolol therapy provided a more manifested antiaggregant effect of the basis treatment, compared to atenolol therapy. Conclusion. DCMP patients, especially ones with ischemic DCMP, demonstrated an increase in platelet aggregation activity. Long-term bisoprolol therapy facilitated a more pronounced anti-aggregant effect of the basis treatment, compared to atenolol treatment.https://cardiovascular.elpub.ru/jour/article/view/1700ischemic dilated cardiomyopathyidiopathic dilated cardiomyopathyplatelet aggregation activitybeta-adrenoblockers |
| spellingShingle | P. N. Isakhanova Yu. N. Ziyaev Kh. A. Mamatkulov M. Kh. Nazarova Sh. I. Makhamatova Platelet aggregation activity and beta-adrenoblocker therapy in patients with dilated cardiomyopathy Кардиоваскулярная терапия и профилактика ischemic dilated cardiomyopathy idiopathic dilated cardiomyopathy platelet aggregation activity beta-adrenoblockers |
| title | Platelet aggregation activity and beta-adrenoblocker therapy in patients with dilated cardiomyopathy |
| title_full | Platelet aggregation activity and beta-adrenoblocker therapy in patients with dilated cardiomyopathy |
| title_fullStr | Platelet aggregation activity and beta-adrenoblocker therapy in patients with dilated cardiomyopathy |
| title_full_unstemmed | Platelet aggregation activity and beta-adrenoblocker therapy in patients with dilated cardiomyopathy |
| title_short | Platelet aggregation activity and beta-adrenoblocker therapy in patients with dilated cardiomyopathy |
| title_sort | platelet aggregation activity and beta adrenoblocker therapy in patients with dilated cardiomyopathy |
| topic | ischemic dilated cardiomyopathy idiopathic dilated cardiomyopathy platelet aggregation activity beta-adrenoblockers |
| url | https://cardiovascular.elpub.ru/jour/article/view/1700 |
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