Diet-Induced Obesity Promotes Liver Metastasis of Pancreatic Ductal Adenocarcinoma via CX3CL1/CX3CR1 Axis
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancers, and the patients are generally diagnosed with distant metastasis. Liver is one of the preferred organs of distant metastasis, and liver metastasis is the leading cause of death in PDAC. Diet-induced obesity (DIO) is a ris...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-01-01
|
| Series: | Journal of Immunology Research |
| Online Access: | http://dx.doi.org/10.1155/2022/5665964 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850179014215335936 |
|---|---|
| author | Yue Sun Xiao-Xin Zhang Shan Huang Hong Pan Yan-Zhi Gai Yao-Qi Zhou Lei Zhu Hui-Zhen Nie Dong-Xue Li |
| author_facet | Yue Sun Xiao-Xin Zhang Shan Huang Hong Pan Yan-Zhi Gai Yao-Qi Zhou Lei Zhu Hui-Zhen Nie Dong-Xue Li |
| author_sort | Yue Sun |
| collection | DOAJ |
| description | Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancers, and the patients are generally diagnosed with distant metastasis. Liver is one of the preferred organs of distant metastasis, and liver metastasis is the leading cause of death in PDAC. Diet-induced obesity (DIO) is a risk factor for PDAC, and it remains unclear whether and how DIO contributes to liver metastasis of PDAC. In our study, we found that DIO significantly promoted PDAC liver metastasis compared with normal diet (ND) in intrasplenic injection mouse model. RNA-seq analysis for liver metastasis nodules showed that the various chemokines and several chemokine receptors were altered between ND and DIO samples. The expression levels of CX3CL1 and CX3CR1 were significantly upregulated in DIO-induced liver metastasis of PDAC compared to ND. Increased CX3CL1 promoted the recruitment of CX3CR1-expressing pancreatic tumor cells. Taken together, our data demonstrated that DIO promoted PDAC liver metastasis via CX3CL1/CX3CR1 axis. |
| format | Article |
| id | doaj-art-bebdbe9f70a1402b8d198ffe4c68867e |
| institution | OA Journals |
| issn | 2314-7156 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Immunology Research |
| spelling | doaj-art-bebdbe9f70a1402b8d198ffe4c68867e2025-08-20T02:18:35ZengWileyJournal of Immunology Research2314-71562022-01-01202210.1155/2022/5665964Diet-Induced Obesity Promotes Liver Metastasis of Pancreatic Ductal Adenocarcinoma via CX3CL1/CX3CR1 AxisYue Sun0Xiao-Xin Zhang1Shan Huang2Hong Pan3Yan-Zhi Gai4Yao-Qi Zhou5Lei Zhu6Hui-Zhen Nie7Dong-Xue Li8State Key Laboratory of Oncogenes and Related GenesJiangsu Key Laboratory of Medical Science and Laboratory MedicineState Key Laboratory of Oncogenes and Related GenesState Key Laboratory of Oncogenes and Related GenesState Key Laboratory of Oncogenes and Related GenesState Key Laboratory of Oncogenes and Related GenesState Key Laboratory of Oncogenes and Related GenesState Key Laboratory of Oncogenes and Related GenesState Key Laboratory of Oncogenes and Related GenesPancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancers, and the patients are generally diagnosed with distant metastasis. Liver is one of the preferred organs of distant metastasis, and liver metastasis is the leading cause of death in PDAC. Diet-induced obesity (DIO) is a risk factor for PDAC, and it remains unclear whether and how DIO contributes to liver metastasis of PDAC. In our study, we found that DIO significantly promoted PDAC liver metastasis compared with normal diet (ND) in intrasplenic injection mouse model. RNA-seq analysis for liver metastasis nodules showed that the various chemokines and several chemokine receptors were altered between ND and DIO samples. The expression levels of CX3CL1 and CX3CR1 were significantly upregulated in DIO-induced liver metastasis of PDAC compared to ND. Increased CX3CL1 promoted the recruitment of CX3CR1-expressing pancreatic tumor cells. Taken together, our data demonstrated that DIO promoted PDAC liver metastasis via CX3CL1/CX3CR1 axis.http://dx.doi.org/10.1155/2022/5665964 |
| spellingShingle | Yue Sun Xiao-Xin Zhang Shan Huang Hong Pan Yan-Zhi Gai Yao-Qi Zhou Lei Zhu Hui-Zhen Nie Dong-Xue Li Diet-Induced Obesity Promotes Liver Metastasis of Pancreatic Ductal Adenocarcinoma via CX3CL1/CX3CR1 Axis Journal of Immunology Research |
| title | Diet-Induced Obesity Promotes Liver Metastasis of Pancreatic Ductal Adenocarcinoma via CX3CL1/CX3CR1 Axis |
| title_full | Diet-Induced Obesity Promotes Liver Metastasis of Pancreatic Ductal Adenocarcinoma via CX3CL1/CX3CR1 Axis |
| title_fullStr | Diet-Induced Obesity Promotes Liver Metastasis of Pancreatic Ductal Adenocarcinoma via CX3CL1/CX3CR1 Axis |
| title_full_unstemmed | Diet-Induced Obesity Promotes Liver Metastasis of Pancreatic Ductal Adenocarcinoma via CX3CL1/CX3CR1 Axis |
| title_short | Diet-Induced Obesity Promotes Liver Metastasis of Pancreatic Ductal Adenocarcinoma via CX3CL1/CX3CR1 Axis |
| title_sort | diet induced obesity promotes liver metastasis of pancreatic ductal adenocarcinoma via cx3cl1 cx3cr1 axis |
| url | http://dx.doi.org/10.1155/2022/5665964 |
| work_keys_str_mv | AT yuesun dietinducedobesitypromoteslivermetastasisofpancreaticductaladenocarcinomaviacx3cl1cx3cr1axis AT xiaoxinzhang dietinducedobesitypromoteslivermetastasisofpancreaticductaladenocarcinomaviacx3cl1cx3cr1axis AT shanhuang dietinducedobesitypromoteslivermetastasisofpancreaticductaladenocarcinomaviacx3cl1cx3cr1axis AT hongpan dietinducedobesitypromoteslivermetastasisofpancreaticductaladenocarcinomaviacx3cl1cx3cr1axis AT yanzhigai dietinducedobesitypromoteslivermetastasisofpancreaticductaladenocarcinomaviacx3cl1cx3cr1axis AT yaoqizhou dietinducedobesitypromoteslivermetastasisofpancreaticductaladenocarcinomaviacx3cl1cx3cr1axis AT leizhu dietinducedobesitypromoteslivermetastasisofpancreaticductaladenocarcinomaviacx3cl1cx3cr1axis AT huizhennie dietinducedobesitypromoteslivermetastasisofpancreaticductaladenocarcinomaviacx3cl1cx3cr1axis AT dongxueli dietinducedobesitypromoteslivermetastasisofpancreaticductaladenocarcinomaviacx3cl1cx3cr1axis |