Fine-scale family structure shapes influenza transmission risk in households: Insights from primary schools in Matsumoto city, 2014/15.
Households are important settings for the transmission of seasonal influenza. Previous studies found that the per-person risk of within-household transmission decreases with household size. However, more detailed heterogeneities driven by household composition and contact patterns have not been stud...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2019-12-01
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| Series: | PLoS Computational Biology |
| Online Access: | https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007589&type=printable |
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| author | Akira Endo Mitsuo Uchida Adam J Kucharski Sebastian Funk |
| author_facet | Akira Endo Mitsuo Uchida Adam J Kucharski Sebastian Funk |
| author_sort | Akira Endo |
| collection | DOAJ |
| description | Households are important settings for the transmission of seasonal influenza. Previous studies found that the per-person risk of within-household transmission decreases with household size. However, more detailed heterogeneities driven by household composition and contact patterns have not been studied. We employed a mathematical model that accounts for infections both from outside and within the household. The model was applied to citywide primary school seasonal influenza surveillance and household surveys from 10,486 students during the 2014/15 season in Matsumoto city, Japan. We compared a range of models to estimate the structure of household transmission and found that familial relationship and household composition strongly influenced the transmission patterns of seasonal influenza in households. Children had a substantially high risk of infection from outside the household (up to 20%) compared with adults (1-3%). Intense transmission was observed within-generation (between children/parents/grandparents) and also between mother and child, with transmission risks typically ranging from 5-20% depending on the transmission route and household composition. Children were identified as the largest source of secondary transmission, with family structure influencing infection risk. |
| format | Article |
| id | doaj-art-bebda289e3d84937ae8bb94563bcc1d8 |
| institution | OA Journals |
| issn | 1553-734X 1553-7358 |
| language | English |
| publishDate | 2019-12-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Computational Biology |
| spelling | doaj-art-bebda289e3d84937ae8bb94563bcc1d82025-08-20T02:00:38ZengPublic Library of Science (PLoS)PLoS Computational Biology1553-734X1553-73582019-12-011512e100758910.1371/journal.pcbi.1007589Fine-scale family structure shapes influenza transmission risk in households: Insights from primary schools in Matsumoto city, 2014/15.Akira EndoMitsuo UchidaAdam J KucharskiSebastian FunkHouseholds are important settings for the transmission of seasonal influenza. Previous studies found that the per-person risk of within-household transmission decreases with household size. However, more detailed heterogeneities driven by household composition and contact patterns have not been studied. We employed a mathematical model that accounts for infections both from outside and within the household. The model was applied to citywide primary school seasonal influenza surveillance and household surveys from 10,486 students during the 2014/15 season in Matsumoto city, Japan. We compared a range of models to estimate the structure of household transmission and found that familial relationship and household composition strongly influenced the transmission patterns of seasonal influenza in households. Children had a substantially high risk of infection from outside the household (up to 20%) compared with adults (1-3%). Intense transmission was observed within-generation (between children/parents/grandparents) and also between mother and child, with transmission risks typically ranging from 5-20% depending on the transmission route and household composition. Children were identified as the largest source of secondary transmission, with family structure influencing infection risk.https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007589&type=printable |
| spellingShingle | Akira Endo Mitsuo Uchida Adam J Kucharski Sebastian Funk Fine-scale family structure shapes influenza transmission risk in households: Insights from primary schools in Matsumoto city, 2014/15. PLoS Computational Biology |
| title | Fine-scale family structure shapes influenza transmission risk in households: Insights from primary schools in Matsumoto city, 2014/15. |
| title_full | Fine-scale family structure shapes influenza transmission risk in households: Insights from primary schools in Matsumoto city, 2014/15. |
| title_fullStr | Fine-scale family structure shapes influenza transmission risk in households: Insights from primary schools in Matsumoto city, 2014/15. |
| title_full_unstemmed | Fine-scale family structure shapes influenza transmission risk in households: Insights from primary schools in Matsumoto city, 2014/15. |
| title_short | Fine-scale family structure shapes influenza transmission risk in households: Insights from primary schools in Matsumoto city, 2014/15. |
| title_sort | fine scale family structure shapes influenza transmission risk in households insights from primary schools in matsumoto city 2014 15 |
| url | https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007589&type=printable |
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