Revolutionizing head and neck squamous cell carcinoma treatment with nanomedicine in the era of immunotherapy
Head and neck squamous cell carcinoma (HNSCC) is a prevalent malignant tumor globally. Despite advancements in treatment methods, the overall survival rate remains low due to limitations such as poor targeting and low bioavailability, which result in the limited efficacy of traditional drug therapie...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-11-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1453753/full |
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| author | Hong-Xia Li Hong-Xia Li Hong-Xia Li Yu-Wen Gong Pi-Jun Yan Yong Xu Gang Qin Wei-Ping Wen Wei-Ping Wen Fang-Yuan Teng |
| author_facet | Hong-Xia Li Hong-Xia Li Hong-Xia Li Yu-Wen Gong Pi-Jun Yan Yong Xu Gang Qin Wei-Ping Wen Wei-Ping Wen Fang-Yuan Teng |
| author_sort | Hong-Xia Li |
| collection | DOAJ |
| description | Head and neck squamous cell carcinoma (HNSCC) is a prevalent malignant tumor globally. Despite advancements in treatment methods, the overall survival rate remains low due to limitations such as poor targeting and low bioavailability, which result in the limited efficacy of traditional drug therapies. Nanomedicine is considered to be a promising strategy in tumor therapy, offering the potential for maximal anti-tumor effects. Nanocarriers can overcome biological barriers, enhance drug delivery efficiency to targeted sites, and minimize damage to normal tissues. Currently, various nano-carriers for drug delivery have been developed to construct new nanomedicine. This review aims to provide an overview of the current status of HNSCC treatment and the necessity of nanomedicine in improving treatment outcomes. Moreover, it delves into the research progress of nanomedicine in HNSCC treatment, with a focus on enhancing radiation sensitivity, improving the efficacy of tumor immunotherapy, effectively delivering chemotherapy drugs, and utilizing small molecule inhibitors. Finally, this article discussed the challenges and prospects of applying nanomedicine in cancer treatment. |
| format | Article |
| id | doaj-art-bebd513e4dd34d2bba9c2c3059d5370d |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-bebd513e4dd34d2bba9c2c3059d5370d2024-11-29T07:09:00ZengFrontiers Media S.A.Frontiers in Immunology1664-32242024-11-011510.3389/fimmu.2024.14537531453753Revolutionizing head and neck squamous cell carcinoma treatment with nanomedicine in the era of immunotherapyHong-Xia Li0Hong-Xia Li1Hong-Xia Li2Yu-Wen Gong3Pi-Jun Yan4Yong Xu5Gang Qin6Wei-Ping Wen7Wei-Ping Wen8Fang-Yuan Teng9Department of Otolaryngology Head and Neck Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaDepartment of Otolaryngology, Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, ChinaMetabolic Vascular Diseases Key Laboratory of Sichuan Province, Metabolic Vascular Diseases Key Laboratory of Sichuan-Chongqing Cooperation, Department of Endocrinology and Metabolism, Luzhou, Sichuan, ChinaDepartment of Otolaryngology, Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, ChinaMetabolic Vascular Diseases Key Laboratory of Sichuan Province, Metabolic Vascular Diseases Key Laboratory of Sichuan-Chongqing Cooperation, Department of Endocrinology and Metabolism, Luzhou, Sichuan, ChinaMetabolic Vascular Diseases Key Laboratory of Sichuan Province, Metabolic Vascular Diseases Key Laboratory of Sichuan-Chongqing Cooperation, Department of Endocrinology and Metabolism, Luzhou, Sichuan, ChinaDepartment of Otolaryngology Head and Neck Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaDepartment of Otolaryngology, Biomedical Innovation Center, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, ChinaDepartment of Otolaryngology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, ChinaMetabolic Vascular Diseases Key Laboratory of Sichuan Province, Metabolic Vascular Diseases Key Laboratory of Sichuan-Chongqing Cooperation, Department of Endocrinology and Metabolism, Luzhou, Sichuan, ChinaHead and neck squamous cell carcinoma (HNSCC) is a prevalent malignant tumor globally. Despite advancements in treatment methods, the overall survival rate remains low due to limitations such as poor targeting and low bioavailability, which result in the limited efficacy of traditional drug therapies. Nanomedicine is considered to be a promising strategy in tumor therapy, offering the potential for maximal anti-tumor effects. Nanocarriers can overcome biological barriers, enhance drug delivery efficiency to targeted sites, and minimize damage to normal tissues. Currently, various nano-carriers for drug delivery have been developed to construct new nanomedicine. This review aims to provide an overview of the current status of HNSCC treatment and the necessity of nanomedicine in improving treatment outcomes. Moreover, it delves into the research progress of nanomedicine in HNSCC treatment, with a focus on enhancing radiation sensitivity, improving the efficacy of tumor immunotherapy, effectively delivering chemotherapy drugs, and utilizing small molecule inhibitors. Finally, this article discussed the challenges and prospects of applying nanomedicine in cancer treatment.https://www.frontiersin.org/articles/10.3389/fimmu.2024.1453753/fullhead and neck squamous cell carcinomananomedicinetreatmenttumor microenvironmentdrug delivery |
| spellingShingle | Hong-Xia Li Hong-Xia Li Hong-Xia Li Yu-Wen Gong Pi-Jun Yan Yong Xu Gang Qin Wei-Ping Wen Wei-Ping Wen Fang-Yuan Teng Revolutionizing head and neck squamous cell carcinoma treatment with nanomedicine in the era of immunotherapy Frontiers in Immunology head and neck squamous cell carcinoma nanomedicine treatment tumor microenvironment drug delivery |
| title | Revolutionizing head and neck squamous cell carcinoma treatment with nanomedicine in the era of immunotherapy |
| title_full | Revolutionizing head and neck squamous cell carcinoma treatment with nanomedicine in the era of immunotherapy |
| title_fullStr | Revolutionizing head and neck squamous cell carcinoma treatment with nanomedicine in the era of immunotherapy |
| title_full_unstemmed | Revolutionizing head and neck squamous cell carcinoma treatment with nanomedicine in the era of immunotherapy |
| title_short | Revolutionizing head and neck squamous cell carcinoma treatment with nanomedicine in the era of immunotherapy |
| title_sort | revolutionizing head and neck squamous cell carcinoma treatment with nanomedicine in the era of immunotherapy |
| topic | head and neck squamous cell carcinoma nanomedicine treatment tumor microenvironment drug delivery |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1453753/full |
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