Consumption of Chinese Tea-Flavor Liquor Improves Circulating Insulin Levels without Affecting Hepatic Lipid Metabolism-Related Gene Expression in Sprague-Dawley Rats
Objective. To examine the effect of two Chinese liquors with quite different nonalcoholic components on insulin sensitivity, tissue polyunsaturated fatty acids (PUFA), and hepatic lipid metabolism in SD rats. Methods. Thirty-three SD rats were randomized into four groups and maintained in each treat...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2013/842343 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849685663748718592 |
|---|---|
| author | Ju-Sheng Zheng Yuan-Qing Fu Qi Chen Tao Huang Jing Yang Duo Li |
| author_facet | Ju-Sheng Zheng Yuan-Qing Fu Qi Chen Tao Huang Jing Yang Duo Li |
| author_sort | Ju-Sheng Zheng |
| collection | DOAJ |
| description | Objective. To examine the effect of two Chinese liquors with quite different nonalcoholic components on insulin sensitivity, tissue polyunsaturated fatty acids (PUFA), and hepatic lipid metabolism in SD rats. Methods. Thirty-three SD rats were randomized into four groups and maintained in each treatment for 10 weeks: Chinese tea-flavor liquor (TFL, n=9), traditional Chinese liquor (TCL, n=8), ethanol control (EC, n=8), and water control (WC, n=8). Results. TFL significantly decreased plasma insulin (P=0.009) and marginally decreased Homeostatic Model Assessment-Insulin Resistance (HOMA-IR) (P=0.05), compared with WC. Hepatic total and n-6 PUFA compositions were significantly decreased in TFL, TCL, and EC groups compared with WC group (P<0.05). TFL significantly increased kidney n-6 PUFA (P=0.05) and total PUFA (P=0.039), compared with EC group. EC group showed significant higher gene expressions of acetyl-CoA carboxylase and steroid response element-binding protein (1c and 2), while there were no significant differences of these gene expressions in TFL or TCL group compared with WC. Conclusions. TFL has a beneficial effect on metabolic disorder in relation to improved circulating insulin levels without affecting hepatic lipid metabolism-related gene expressions in rats. |
| format | Article |
| id | doaj-art-bebb3bc921224a919c122e158d5fef28 |
| institution | DOAJ |
| issn | 1537-744X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-bebb3bc921224a919c122e158d5fef282025-08-20T03:23:02ZengWileyThe Scientific World Journal1537-744X2013-01-01201310.1155/2013/842343842343Consumption of Chinese Tea-Flavor Liquor Improves Circulating Insulin Levels without Affecting Hepatic Lipid Metabolism-Related Gene Expression in Sprague-Dawley RatsJu-Sheng Zheng0Yuan-Qing Fu1Qi Chen2Tao Huang3Jing Yang4Duo Li5Department of Food Science and Nutrition, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, ChinaDepartment of Food Science and Nutrition, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, ChinaDepartment of Food Science and Nutrition, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, ChinaDepartment of Food Science and Nutrition, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, ChinaDepartment of Food Science and Nutrition, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, ChinaDepartment of Food Science and Nutrition, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, ChinaObjective. To examine the effect of two Chinese liquors with quite different nonalcoholic components on insulin sensitivity, tissue polyunsaturated fatty acids (PUFA), and hepatic lipid metabolism in SD rats. Methods. Thirty-three SD rats were randomized into four groups and maintained in each treatment for 10 weeks: Chinese tea-flavor liquor (TFL, n=9), traditional Chinese liquor (TCL, n=8), ethanol control (EC, n=8), and water control (WC, n=8). Results. TFL significantly decreased plasma insulin (P=0.009) and marginally decreased Homeostatic Model Assessment-Insulin Resistance (HOMA-IR) (P=0.05), compared with WC. Hepatic total and n-6 PUFA compositions were significantly decreased in TFL, TCL, and EC groups compared with WC group (P<0.05). TFL significantly increased kidney n-6 PUFA (P=0.05) and total PUFA (P=0.039), compared with EC group. EC group showed significant higher gene expressions of acetyl-CoA carboxylase and steroid response element-binding protein (1c and 2), while there were no significant differences of these gene expressions in TFL or TCL group compared with WC. Conclusions. TFL has a beneficial effect on metabolic disorder in relation to improved circulating insulin levels without affecting hepatic lipid metabolism-related gene expressions in rats.http://dx.doi.org/10.1155/2013/842343 |
| spellingShingle | Ju-Sheng Zheng Yuan-Qing Fu Qi Chen Tao Huang Jing Yang Duo Li Consumption of Chinese Tea-Flavor Liquor Improves Circulating Insulin Levels without Affecting Hepatic Lipid Metabolism-Related Gene Expression in Sprague-Dawley Rats The Scientific World Journal |
| title | Consumption of Chinese Tea-Flavor Liquor Improves Circulating Insulin Levels without Affecting Hepatic Lipid Metabolism-Related Gene Expression in Sprague-Dawley Rats |
| title_full | Consumption of Chinese Tea-Flavor Liquor Improves Circulating Insulin Levels without Affecting Hepatic Lipid Metabolism-Related Gene Expression in Sprague-Dawley Rats |
| title_fullStr | Consumption of Chinese Tea-Flavor Liquor Improves Circulating Insulin Levels without Affecting Hepatic Lipid Metabolism-Related Gene Expression in Sprague-Dawley Rats |
| title_full_unstemmed | Consumption of Chinese Tea-Flavor Liquor Improves Circulating Insulin Levels without Affecting Hepatic Lipid Metabolism-Related Gene Expression in Sprague-Dawley Rats |
| title_short | Consumption of Chinese Tea-Flavor Liquor Improves Circulating Insulin Levels without Affecting Hepatic Lipid Metabolism-Related Gene Expression in Sprague-Dawley Rats |
| title_sort | consumption of chinese tea flavor liquor improves circulating insulin levels without affecting hepatic lipid metabolism related gene expression in sprague dawley rats |
| url | http://dx.doi.org/10.1155/2013/842343 |
| work_keys_str_mv | AT jushengzheng consumptionofchineseteaflavorliquorimprovescirculatinginsulinlevelswithoutaffectinghepaticlipidmetabolismrelatedgeneexpressioninspraguedawleyrats AT yuanqingfu consumptionofchineseteaflavorliquorimprovescirculatinginsulinlevelswithoutaffectinghepaticlipidmetabolismrelatedgeneexpressioninspraguedawleyrats AT qichen consumptionofchineseteaflavorliquorimprovescirculatinginsulinlevelswithoutaffectinghepaticlipidmetabolismrelatedgeneexpressioninspraguedawleyrats AT taohuang consumptionofchineseteaflavorliquorimprovescirculatinginsulinlevelswithoutaffectinghepaticlipidmetabolismrelatedgeneexpressioninspraguedawleyrats AT jingyang consumptionofchineseteaflavorliquorimprovescirculatinginsulinlevelswithoutaffectinghepaticlipidmetabolismrelatedgeneexpressioninspraguedawleyrats AT duoli consumptionofchineseteaflavorliquorimprovescirculatinginsulinlevelswithoutaffectinghepaticlipidmetabolismrelatedgeneexpressioninspraguedawleyrats |