Chondroitin Sulfate as a Lysosomal Enhancer Attenuates Lipid-Driven Inflammation via Lipophagy and Mitophagy

Chondroitin Sulfate as a Lysosomal Enhancer Attenuates Lipid-Driven Inflammation via Lipophagy and Mitophagy

Non-alcoholic steatohepatitis (NASH), a progressive liver disease characterized by lipid accumulation and chronic inflammation, lacks effective therapies targeting its multifactorial pathogenesis. This study investigates marine-derived chondroitin sulfate (CS) as a multi-organelle modulator capable...

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Bibliographic Details
Main Authors: Ting Sun, Huimin Lv, Huarong Shao, Xiuhua Zhang, Anqi Wang, Wei Zhang, Fei Liu, Peixue Ling
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Marine Drugs
Subjects:
non-alcoholic steatohepatitis
chondroitin sulfate
subcellular regulation
lysosomal acidification
lipid metabolism
mitochondrial autophagy
Online Access:https://www.mdpi.com/1660-3397/23/6/228
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