Choroid Plexus Volume Only Increases Early after Traumatic Brain Injury and Only in Those with Positive Head Computed Tomography Scans
Traumatic brain injury (TBI) affects nearly 2.5 million people each year and results in a cascade of neurometabolic effects, including prolonged inflammatory processes. Choroid plexus (ChP) swelling has been postulated to occur following TBI due to neuroinflammation. However, it is unknown if the Ch...
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Mary Ann Liebert
2024-11-01
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| Series: | Neurotrauma Reports |
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| Online Access: | https://www.liebertpub.com/doi/10.1089/neur.2024.0093 |
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| author | Emma M. Tinney Ryan Luke Sodemann Goretti España-Irla Madeleine Perko Charles H. Hillman Timothy P. Morris |
| author_facet | Emma M. Tinney Ryan Luke Sodemann Goretti España-Irla Madeleine Perko Charles H. Hillman Timothy P. Morris |
| author_sort | Emma M. Tinney |
| collection | DOAJ |
| description | Traumatic brain injury (TBI) affects nearly 2.5 million people each year and results in a cascade of neurometabolic effects, including prolonged inflammatory processes. Choroid plexus (ChP) swelling has been postulated to occur following TBI due to neuroinflammation. However, it is unknown if the ChP swells as a consequence of the post-TBI neuroinflammatory cascade, and it is unknown if swelling could be detectable via human volumetric imaging. Therefore, this study aims to test for the effect of TBI on ChP volume using a case–control study design. Data were acquired from two independent datasets, both of which were comprised of patients who underwent magnetic resonance imaging. First, the Alzheimer’s Disease Neuroimaging Initiative (ADNI) included 156 older adult veterans (70.1 years) with prior moderate-to-severe TBIs and 103 older adult veterans (69.1 years) without a TBI. Second, the Transforming Research and Clinical Knowledge in TBI (TRACK-TBI) included 484 participants (38.4 years) with a recent mild TBI and 92 controls (37.9 years). There were no differences found in TBI ChP volume compared with controls in either ADNI/Department of Defense with those with a history of TBI or TRACK-TBI at 2 weeks postinjury or 6 months postinjury. However, there were significant ChP differences in those with a visible pathology from head computed tomography (CT) scans compared with those without orthopedic controls. These results suggest that ChP swelling occurs only in those with CT. These findings highlight that inflammation after a TBI does manifest in volumetric increases in the ChP, but it is dependent on the pathological features of the TBI. |
| format | Article |
| id | doaj-art-beb48c0b17df40688cb9dd4539614afa |
| institution | OA Journals |
| issn | 2689-288X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Mary Ann Liebert |
| record_format | Article |
| series | Neurotrauma Reports |
| spelling | doaj-art-beb48c0b17df40688cb9dd4539614afa2025-08-20T02:30:49ZengMary Ann LiebertNeurotrauma Reports2689-288X2024-11-01511173118510.1089/neur.2024.0093Choroid Plexus Volume Only Increases Early after Traumatic Brain Injury and Only in Those with Positive Head Computed Tomography ScansEmma M. Tinney0Ryan Luke Sodemann1Goretti España-Irla2Madeleine Perko3Charles H. Hillman4Timothy P. Morris5Department of Psychology, Northeastern University, Boston, Massachusetts, USA.Center for Cognitive & Brain Health, Northeastern University, Boston, Massachusetts, USA.Center for Cognitive & Brain Health, Northeastern University, Boston, Massachusetts, USA.Center for Cognitive & Brain Health, Northeastern University, Boston, Massachusetts, USA.Department of Psychology, Northeastern University, Boston, Massachusetts, USA.Center for Cognitive & Brain Health, Northeastern University, Boston, Massachusetts, USA.Traumatic brain injury (TBI) affects nearly 2.5 million people each year and results in a cascade of neurometabolic effects, including prolonged inflammatory processes. Choroid plexus (ChP) swelling has been postulated to occur following TBI due to neuroinflammation. However, it is unknown if the ChP swells as a consequence of the post-TBI neuroinflammatory cascade, and it is unknown if swelling could be detectable via human volumetric imaging. Therefore, this study aims to test for the effect of TBI on ChP volume using a case–control study design. Data were acquired from two independent datasets, both of which were comprised of patients who underwent magnetic resonance imaging. First, the Alzheimer’s Disease Neuroimaging Initiative (ADNI) included 156 older adult veterans (70.1 years) with prior moderate-to-severe TBIs and 103 older adult veterans (69.1 years) without a TBI. Second, the Transforming Research and Clinical Knowledge in TBI (TRACK-TBI) included 484 participants (38.4 years) with a recent mild TBI and 92 controls (37.9 years). There were no differences found in TBI ChP volume compared with controls in either ADNI/Department of Defense with those with a history of TBI or TRACK-TBI at 2 weeks postinjury or 6 months postinjury. However, there were significant ChP differences in those with a visible pathology from head computed tomography (CT) scans compared with those without orthopedic controls. These results suggest that ChP swelling occurs only in those with CT. These findings highlight that inflammation after a TBI does manifest in volumetric increases in the ChP, but it is dependent on the pathological features of the TBI.https://www.liebertpub.com/doi/10.1089/neur.2024.0093choroid plexusMRITBI |
| spellingShingle | Emma M. Tinney Ryan Luke Sodemann Goretti España-Irla Madeleine Perko Charles H. Hillman Timothy P. Morris Choroid Plexus Volume Only Increases Early after Traumatic Brain Injury and Only in Those with Positive Head Computed Tomography Scans Neurotrauma Reports choroid plexus MRI TBI |
| title | Choroid Plexus Volume Only Increases Early after Traumatic Brain Injury and Only in Those with Positive Head Computed Tomography Scans |
| title_full | Choroid Plexus Volume Only Increases Early after Traumatic Brain Injury and Only in Those with Positive Head Computed Tomography Scans |
| title_fullStr | Choroid Plexus Volume Only Increases Early after Traumatic Brain Injury and Only in Those with Positive Head Computed Tomography Scans |
| title_full_unstemmed | Choroid Plexus Volume Only Increases Early after Traumatic Brain Injury and Only in Those with Positive Head Computed Tomography Scans |
| title_short | Choroid Plexus Volume Only Increases Early after Traumatic Brain Injury and Only in Those with Positive Head Computed Tomography Scans |
| title_sort | choroid plexus volume only increases early after traumatic brain injury and only in those with positive head computed tomography scans |
| topic | choroid plexus MRI TBI |
| url | https://www.liebertpub.com/doi/10.1089/neur.2024.0093 |
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