Exercise-induced neurogenesis through BDNF-TrkB pathway: implications for neurodegenerative disorders
Current scientific endeavours in the field of geroscience have begun to reveal how factors such as exercise could modulate the brain aging process. In this review, we ask how exercise could potentially modulate aging, and by extension, the development of Alzheimer’s Disease (AD). Furthermore, we dis...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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De Gruyter
2025-02-01
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| Series: | Translational Exercise Biomedicine |
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| Online Access: | https://doi.org/10.1515/teb-2024-0038 |
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| _version_ | 1849242953476734976 |
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| author | Lee Jun Jie Sitjar Patrick Henry Sebastian Ang Eng Tat Goh Jorming |
| author_facet | Lee Jun Jie Sitjar Patrick Henry Sebastian Ang Eng Tat Goh Jorming |
| author_sort | Lee Jun Jie |
| collection | DOAJ |
| description | Current scientific endeavours in the field of geroscience have begun to reveal how factors such as exercise could modulate the brain aging process. In this review, we ask how exercise could potentially modulate aging, and by extension, the development of Alzheimer’s Disease (AD). Furthermore, we discuss how exercise could mitigate the cascade of debilitating manifestations in AD. Mechanistically, we discuss how biomolecules such as brain-derived neurotrophic factor (BDNF) and its cognate receptor, tropomyosin receptor kinase B (TrkB) could change during the life course and how its signalling pathways could be altered with exercise (acute sessions or chronic training). Tackling these questions could help the scientific and medical community mitigate age-related decline in terms of neurological functions. |
| format | Article |
| id | doaj-art-beaea255c810496d93318cc3e1bfa889 |
| institution | Kabale University |
| issn | 2942-6812 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | De Gruyter |
| record_format | Article |
| series | Translational Exercise Biomedicine |
| spelling | doaj-art-beaea255c810496d93318cc3e1bfa8892025-08-20T03:59:39ZengDe GruyterTranslational Exercise Biomedicine2942-68122025-02-0121212910.1515/teb-2024-0038Exercise-induced neurogenesis through BDNF-TrkB pathway: implications for neurodegenerative disordersLee Jun Jie0Sitjar Patrick Henry Sebastian1Ang Eng Tat2Goh Jorming3Preventive Medicine Residency, National University Health System (NUHS), Singapore, SingaporeExercise Physiology & Biomarkers Laboratory, Yong Loo Lin School of Medicine, 37580National University of Singapore (NUS), Singapore, SingaporeDuke-NUS Medical School, Singapore, Republic of SingaporeExercise Physiology & Biomarkers Laboratory, Yong Loo Lin School of Medicine, 37580National University of Singapore (NUS), Singapore, SingaporeCurrent scientific endeavours in the field of geroscience have begun to reveal how factors such as exercise could modulate the brain aging process. In this review, we ask how exercise could potentially modulate aging, and by extension, the development of Alzheimer’s Disease (AD). Furthermore, we discuss how exercise could mitigate the cascade of debilitating manifestations in AD. Mechanistically, we discuss how biomolecules such as brain-derived neurotrophic factor (BDNF) and its cognate receptor, tropomyosin receptor kinase B (TrkB) could change during the life course and how its signalling pathways could be altered with exercise (acute sessions or chronic training). Tackling these questions could help the scientific and medical community mitigate age-related decline in terms of neurological functions.https://doi.org/10.1515/teb-2024-0038exercisebdnfneurogenesisalzheimer’s disease |
| spellingShingle | Lee Jun Jie Sitjar Patrick Henry Sebastian Ang Eng Tat Goh Jorming Exercise-induced neurogenesis through BDNF-TrkB pathway: implications for neurodegenerative disorders Translational Exercise Biomedicine exercise bdnf neurogenesis alzheimer’s disease |
| title | Exercise-induced neurogenesis through BDNF-TrkB pathway: implications for neurodegenerative disorders |
| title_full | Exercise-induced neurogenesis through BDNF-TrkB pathway: implications for neurodegenerative disorders |
| title_fullStr | Exercise-induced neurogenesis through BDNF-TrkB pathway: implications for neurodegenerative disorders |
| title_full_unstemmed | Exercise-induced neurogenesis through BDNF-TrkB pathway: implications for neurodegenerative disorders |
| title_short | Exercise-induced neurogenesis through BDNF-TrkB pathway: implications for neurodegenerative disorders |
| title_sort | exercise induced neurogenesis through bdnf trkb pathway implications for neurodegenerative disorders |
| topic | exercise bdnf neurogenesis alzheimer’s disease |
| url | https://doi.org/10.1515/teb-2024-0038 |
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