Structure and biological action of analogs and derivatives of biogenic polyamines
Objectives. Biogenic polyamines are widely present in nature. They are characteristic of both protozoan cells and multicellular organisms. These compounds have a wide range of biological functions and are necessary for normal growth and development of cells. Violation of polyamine homeostasis can ca...
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| Format: | Article |
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MIREA - Russian Technological University
2021-09-01
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| Series: | Тонкие химические технологии |
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| Online Access: | https://www.finechem-mirea.ru/jour/article/view/1724 |
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| author | O. S. Egorov N. Yu. Borisova E. Ya. Borisova M. L. Rezhabbaev E. Yu. Afanas’eva E. V. Arzamastsev |
| author_facet | O. S. Egorov N. Yu. Borisova E. Ya. Borisova M. L. Rezhabbaev E. Yu. Afanas’eva E. V. Arzamastsev |
| author_sort | O. S. Egorov |
| collection | DOAJ |
| description | Objectives. Biogenic polyamines are widely present in nature. They are characteristic of both protozoan cells and multicellular organisms. These compounds have a wide range of biological functions and are necessary for normal growth and development of cells. Violation of polyamine homeostasis can cause significant abnormalities in cell functioning, provoking various pathological processes, including oncological and neuropsychiatric diseases. The impact on the “polyamine pathway” is an attractive basis for the creation of many pharmacological agents with a diverse spectrum of action. The purpose of this review is to summarize the results of the studies devoted to understanding the biological activity of compounds of the polyamine series, comparing their biological action with action on certain molecular targets. Due to the structural diversity of this group of substances, it is impossible to fully reflect the currently available data in one review. Therefore, in this work, the main attention is paid to the derivatives, acyclic saturated polyamines.Results. The following aspects are considered: biological functionality, biosynthesis and catabolism, cell transport, and localization of biogenic polyamines in the living systems. Structural analogs and derivatives of biogenic polyamines with antitumor, neuroprotective, antiarrhythmic, antiparasitic, antibacterial, and other biological activities are represented; the relationship between biological activity and the target of exposure is reflected. It was found that the nature of the substituent, the number of cationic centers, and the length of the polyamine chain have a great influence on the nature of the effect.Conclusions. At present, the use of polyamine structures is restrained by cytotoxicity and nonspecific toxic effects on the central nervous system. Further research in the field of biochemistry, cell transport, and a deeper understanding of receptor interaction mechanisms will help making polyamines as the basis for potential drug formulation. |
| format | Article |
| id | doaj-art-bead4f8b9c8841d38cdb5cca26f37ae6 |
| institution | DOAJ |
| issn | 2410-6593 2686-7575 |
| language | Russian |
| publishDate | 2021-09-01 |
| publisher | MIREA - Russian Technological University |
| record_format | Article |
| series | Тонкие химические технологии |
| spelling | doaj-art-bead4f8b9c8841d38cdb5cca26f37ae62025-08-20T03:23:07ZrusMIREA - Russian Technological UniversityТонкие химические технологии2410-65932686-75752021-09-0116428730610.32362/2410-6593-2021-16-4-287-3061644Structure and biological action of analogs and derivatives of biogenic polyaminesO. S. Egorov0N. Yu. Borisova1E. Ya. Borisova2M. L. Rezhabbaev3E. Yu. Afanas’eva4E. V. Arzamastsev5MIREA – Russian Technological UniversityMIREA – Russian Technological UniversityMIREA – Russian Technological UniversityMIREA – Russian Technological UniversityNational Medical Research Center of Cardiology, Ministry of Health of the Russian FederationNational Medical Research Center of Cardiology, Ministry of Health of the Russian FederationObjectives. Biogenic polyamines are widely present in nature. They are characteristic of both protozoan cells and multicellular organisms. These compounds have a wide range of biological functions and are necessary for normal growth and development of cells. Violation of polyamine homeostasis can cause significant abnormalities in cell functioning, provoking various pathological processes, including oncological and neuropsychiatric diseases. The impact on the “polyamine pathway” is an attractive basis for the creation of many pharmacological agents with a diverse spectrum of action. The purpose of this review is to summarize the results of the studies devoted to understanding the biological activity of compounds of the polyamine series, comparing their biological action with action on certain molecular targets. Due to the structural diversity of this group of substances, it is impossible to fully reflect the currently available data in one review. Therefore, in this work, the main attention is paid to the derivatives, acyclic saturated polyamines.Results. The following aspects are considered: biological functionality, biosynthesis and catabolism, cell transport, and localization of biogenic polyamines in the living systems. Structural analogs and derivatives of biogenic polyamines with antitumor, neuroprotective, antiarrhythmic, antiparasitic, antibacterial, and other biological activities are represented; the relationship between biological activity and the target of exposure is reflected. It was found that the nature of the substituent, the number of cationic centers, and the length of the polyamine chain have a great influence on the nature of the effect.Conclusions. At present, the use of polyamine structures is restrained by cytotoxicity and nonspecific toxic effects on the central nervous system. Further research in the field of biochemistry, cell transport, and a deeper understanding of receptor interaction mechanisms will help making polyamines as the basis for potential drug formulation.https://www.finechem-mirea.ru/jour/article/view/1724polyaminesbiogenic aminesputrescinepolyamine derivativessperminespermidinepolyamine biosynthesispolyamine catabolismpolyamine transportantiarrhythmic activityantibacterial activityantitumor activitypolyamine analogsneurodegenerative diseases |
| spellingShingle | O. S. Egorov N. Yu. Borisova E. Ya. Borisova M. L. Rezhabbaev E. Yu. Afanas’eva E. V. Arzamastsev Structure and biological action of analogs and derivatives of biogenic polyamines Тонкие химические технологии polyamines biogenic amines putrescine polyamine derivatives spermine spermidine polyamine biosynthesis polyamine catabolism polyamine transport antiarrhythmic activity antibacterial activity antitumor activity polyamine analogs neurodegenerative diseases |
| title | Structure and biological action of analogs and derivatives of biogenic polyamines |
| title_full | Structure and biological action of analogs and derivatives of biogenic polyamines |
| title_fullStr | Structure and biological action of analogs and derivatives of biogenic polyamines |
| title_full_unstemmed | Structure and biological action of analogs and derivatives of biogenic polyamines |
| title_short | Structure and biological action of analogs and derivatives of biogenic polyamines |
| title_sort | structure and biological action of analogs and derivatives of biogenic polyamines |
| topic | polyamines biogenic amines putrescine polyamine derivatives spermine spermidine polyamine biosynthesis polyamine catabolism polyamine transport antiarrhythmic activity antibacterial activity antitumor activity polyamine analogs neurodegenerative diseases |
| url | https://www.finechem-mirea.ru/jour/article/view/1724 |
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