Assessment of the Nutritional Status and Skeletal Muscle Condition in Patients With Resectable Gastric Cancer
Background: Patients with gastric cancer (GC) are at high risk of nutrient deficiencies (ND) that can negatively affect the postoperative period and long-term treatment outcomes.Objective: To assess the nutritional status (NS) and skeletal muscle condition in patients with resectable stage I-III GC....
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Scientific Research Institute, Ochapovsky Regional Clinical Hospital no. 1
2024-03-01
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| Series: | Инновационная медицина Кубани |
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| Online Access: | https://www.innovmedkub.ru/jour/article/view/812 |
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| author | I. B. Uvarov O. M. Asipovich S. N. Derbenev A. V. Yashchenko D. V. Andreev V. A. Porhanov A. M. Manuilov |
| author_facet | I. B. Uvarov O. M. Asipovich S. N. Derbenev A. V. Yashchenko D. V. Andreev V. A. Porhanov A. M. Manuilov |
| author_sort | I. B. Uvarov |
| collection | DOAJ |
| description | Background: Patients with gastric cancer (GC) are at high risk of nutrient deficiencies (ND) that can negatively affect the postoperative period and long-term treatment outcomes.Objective: To assess the nutritional status (NS) and skeletal muscle condition in patients with resectable stage I-III GC.Materials and methods: Our study included 102 GC patients: 64 men (62.7%) and 38 women (37.3%) aged 31 to 77 years. During the assessment we used the NRS-2002 system, determined laboratory markers of the NS, calculated the Nutritional Risk Index (NRI), and evaluated the condition of adipose tissue and skeletal muscles using computed tomography.Results: We found that 70.6% of the patients had ND: NRS-2002 score < 3 points (52%) and NRS-2002 score ≥ 3 points (18.6%). Risk factors for ND were tumor localization in the cardia and stage III GC. Laboratory markers of ND were transferrin and NRI. Among the examined patients (n = 80) sarcopenia was detected in 10 (12.5%) patients: 1 patient (1/25; 4.0%) from the group without ND, 6 patients (6/42; 14.3%) from the group with NRS-2002 score < 3 points, and 3 patients (3/13; 23.1%) from the group with NRS2002 score ≥ 3 points, (P = .212). In multivariate logistic regression analysis, independent factors associated with sarcopenia were age, body mass index, and total protein.Conclusions: All GC patients selected for radical surgery should undergo nutritional assessment using special tools (NRS-2002, NRI) and evaluation of the skeletal muscle condition. Sarcopenia may occur in patients with no clinical or laboratory evidence of ND. In GC patients at nutritional risk, preand postoperative nutritional support should be considered to reduce the ND-related risks. |
| format | Article |
| id | doaj-art-bea92eccfd224b7db9291cc320d5764b |
| institution | Kabale University |
| issn | 2541-9897 |
| language | English |
| publishDate | 2024-03-01 |
| publisher | Scientific Research Institute, Ochapovsky Regional Clinical Hospital no. 1 |
| record_format | Article |
| series | Инновационная медицина Кубани |
| spelling | doaj-art-bea92eccfd224b7db9291cc320d5764b2025-08-20T03:47:32ZengScientific Research Institute, Ochapovsky Regional Clinical Hospital no. 1Инновационная медицина Кубани2541-98972024-03-0101697710.35401/2541-9897-2024-9-1-69-77428Assessment of the Nutritional Status and Skeletal Muscle Condition in Patients With Resectable Gastric CancerI. B. Uvarov0O. M. Asipovich1S. N. Derbenev2A. V. Yashchenko3D. V. Andreev4V. A. Porhanov5A. M. Manuilov6Kuban State Medical University; Clinical Oncology Dispensary No. 1Kuban State Medical University; Clinical Oncology Dispensary No. 1Kuban State Medical University; Clinical Oncology Dispensary No. 1Kuban State Medical University; Clinical Oncology Dispensary No. 1Kuban State Medical University; Clinical Oncology Dispensary No. 1Kuban State Medical University; Scientific Research Institute – Ochapovsky Regional Clinical Hospital No. 1Kuban State Medical UniversityBackground: Patients with gastric cancer (GC) are at high risk of nutrient deficiencies (ND) that can negatively affect the postoperative period and long-term treatment outcomes.Objective: To assess the nutritional status (NS) and skeletal muscle condition in patients with resectable stage I-III GC.Materials and methods: Our study included 102 GC patients: 64 men (62.7%) and 38 women (37.3%) aged 31 to 77 years. During the assessment we used the NRS-2002 system, determined laboratory markers of the NS, calculated the Nutritional Risk Index (NRI), and evaluated the condition of adipose tissue and skeletal muscles using computed tomography.Results: We found that 70.6% of the patients had ND: NRS-2002 score < 3 points (52%) and NRS-2002 score ≥ 3 points (18.6%). Risk factors for ND were tumor localization in the cardia and stage III GC. Laboratory markers of ND were transferrin and NRI. Among the examined patients (n = 80) sarcopenia was detected in 10 (12.5%) patients: 1 patient (1/25; 4.0%) from the group without ND, 6 patients (6/42; 14.3%) from the group with NRS-2002 score < 3 points, and 3 patients (3/13; 23.1%) from the group with NRS2002 score ≥ 3 points, (P = .212). In multivariate logistic regression analysis, independent factors associated with sarcopenia were age, body mass index, and total protein.Conclusions: All GC patients selected for radical surgery should undergo nutritional assessment using special tools (NRS-2002, NRI) and evaluation of the skeletal muscle condition. Sarcopenia may occur in patients with no clinical or laboratory evidence of ND. In GC patients at nutritional risk, preand postoperative nutritional support should be considered to reduce the ND-related risks.https://www.innovmedkub.ru/jour/article/view/812gastric cancersurgical treatmentnutritional statusnutrient deficiencynutritional risk screeningsarcopenia |
| spellingShingle | I. B. Uvarov O. M. Asipovich S. N. Derbenev A. V. Yashchenko D. V. Andreev V. A. Porhanov A. M. Manuilov Assessment of the Nutritional Status and Skeletal Muscle Condition in Patients With Resectable Gastric Cancer Инновационная медицина Кубани gastric cancer surgical treatment nutritional status nutrient deficiency nutritional risk screening sarcopenia |
| title | Assessment of the Nutritional Status and Skeletal Muscle Condition in Patients With Resectable Gastric Cancer |
| title_full | Assessment of the Nutritional Status and Skeletal Muscle Condition in Patients With Resectable Gastric Cancer |
| title_fullStr | Assessment of the Nutritional Status and Skeletal Muscle Condition in Patients With Resectable Gastric Cancer |
| title_full_unstemmed | Assessment of the Nutritional Status and Skeletal Muscle Condition in Patients With Resectable Gastric Cancer |
| title_short | Assessment of the Nutritional Status and Skeletal Muscle Condition in Patients With Resectable Gastric Cancer |
| title_sort | assessment of the nutritional status and skeletal muscle condition in patients with resectable gastric cancer |
| topic | gastric cancer surgical treatment nutritional status nutrient deficiency nutritional risk screening sarcopenia |
| url | https://www.innovmedkub.ru/jour/article/view/812 |
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