Biases and complementarity in gut viromes obtained from bulk and virus-like particle-enriched metagenomic sequencing

Biases and complementarity in gut viromes obtained from bulk and virus-like particle-enriched metagenomic sequencing

ABSTRACT Due to varying sequencing strategies, current gut virome findings show significant variability. Specifically, bulk- and virus-like particle (VLP)-enriched metagenomic sequencing (termed bulk and VLP, respectively) present unique advantages and limitations, affecting viral genome discovery,...

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Bibliographic Details
Main Authors: Yun Li, Chuqing Sun, Jiaying Zhu, Mingyan Geng, Min Li, Xing-Ming Zhao, Wei-Hua Chen
Format: Article
Language:English
Published: American Society for Microbiology 2025-08-01
Series:Microbiology Spectrum
Subjects:
virome
bulk-metagenomic sequencing
viral-like particle metagenomic sequencing
gut virus
gut phage
gut health
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00013-25
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