Prospects and challenges of selectivity proteinuria index in clinical practices
Plasma proteins are selectively filtrated by glomerular filtration membrane due to their sizes and charge barriers. By comparing renal clearance of a larger molecular weight to a smaller molecular weight protein in plasma, selectivity proteinuria index (SPI) reflects the severity of injury in glomer...
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Editorial Department of Journal of Clinical Nephrology
2024-11-01
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| Series: | Linchuang shenzangbing zazhi |
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| Online Access: | http://www.lcszb.com/cn/article/doi/10.3969/j.issn.1671-2390.2024.11.010 |
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| author | Qi-liang Chen Bing Dai |
| author_facet | Qi-liang Chen Bing Dai |
| author_sort | Qi-liang Chen |
| collection | DOAJ |
| description | Plasma proteins are selectively filtrated by glomerular filtration membrane due to their sizes and charge barriers. By comparing renal clearance of a larger molecular weight to a smaller molecular weight protein in plasma, selectivity proteinuria index (SPI) reflects the severity of injury in glomerular filtration membrane as well as the change of overall glomerular permeability in active nephrons. SPI is not only a convenient marker for patients with contraindications to renal biopsy and may be applied in areas where renal biopsy technique is not available, but also makes up for defects of focal renal biopsy tissues. Kidney Disease: Improving Global Outcomes (KDIGO) Guideline for Membranous Nephropathy has proposed SPI as one of the clinical indicators for risk stratification, initiation and decision on therapeutic strategies. However, SPI also has such limitations as inconsistent formulae, suboptimal specificity and complicated interfering factors. It is of great significance to guide clinical practices along with other indicators. This review summarized the basic principles, calculation methods, clinical application values and challenges of SPI. |
| format | Article |
| id | doaj-art-bea637eb614445d1a91eabcff47b3481 |
| institution | OA Journals |
| issn | 1671-2390 |
| language | zho |
| publishDate | 2024-11-01 |
| publisher | Editorial Department of Journal of Clinical Nephrology |
| record_format | Article |
| series | Linchuang shenzangbing zazhi |
| spelling | doaj-art-bea637eb614445d1a91eabcff47b34812025-08-20T02:05:13ZzhoEditorial Department of Journal of Clinical NephrologyLinchuang shenzangbing zazhi1671-23902024-11-01241195195510.3969/j.issn.1671-2390.2024.11.01020240052Prospects and challenges of selectivity proteinuria index in clinical practicesQi-liang ChenBing DaiPlasma proteins are selectively filtrated by glomerular filtration membrane due to their sizes and charge barriers. By comparing renal clearance of a larger molecular weight to a smaller molecular weight protein in plasma, selectivity proteinuria index (SPI) reflects the severity of injury in glomerular filtration membrane as well as the change of overall glomerular permeability in active nephrons. SPI is not only a convenient marker for patients with contraindications to renal biopsy and may be applied in areas where renal biopsy technique is not available, but also makes up for defects of focal renal biopsy tissues. Kidney Disease: Improving Global Outcomes (KDIGO) Guideline for Membranous Nephropathy has proposed SPI as one of the clinical indicators for risk stratification, initiation and decision on therapeutic strategies. However, SPI also has such limitations as inconsistent formulae, suboptimal specificity and complicated interfering factors. It is of great significance to guide clinical practices along with other indicators. This review summarized the basic principles, calculation methods, clinical application values and challenges of SPI.http://www.lcszb.com/cn/article/doi/10.3969/j.issn.1671-2390.2024.11.010selectivity proteinuria indexchronic kidney diseaseglomerular filtration membrane |
| spellingShingle | Qi-liang Chen Bing Dai Prospects and challenges of selectivity proteinuria index in clinical practices Linchuang shenzangbing zazhi selectivity proteinuria index chronic kidney disease glomerular filtration membrane |
| title | Prospects and challenges of selectivity proteinuria index in clinical practices |
| title_full | Prospects and challenges of selectivity proteinuria index in clinical practices |
| title_fullStr | Prospects and challenges of selectivity proteinuria index in clinical practices |
| title_full_unstemmed | Prospects and challenges of selectivity proteinuria index in clinical practices |
| title_short | Prospects and challenges of selectivity proteinuria index in clinical practices |
| title_sort | prospects and challenges of selectivity proteinuria index in clinical practices |
| topic | selectivity proteinuria index chronic kidney disease glomerular filtration membrane |
| url | http://www.lcszb.com/cn/article/doi/10.3969/j.issn.1671-2390.2024.11.010 |
| work_keys_str_mv | AT qiliangchen prospectsandchallengesofselectivityproteinuriaindexinclinicalpractices AT bingdai prospectsandchallengesofselectivityproteinuriaindexinclinicalpractices |