Using de novo assembly to identify structural variation of eight complex immune system gene regions.

Using de novo assembly to identify structural variation of eight complex immune system gene regions.

Driven by the necessity to survive environmental pathogens, the human immune system has evolved exceptional diversity and plasticity, to which several factors contribute including inheritable structural polymorphism of the underlying genes. Characterizing this variation is challenging due to the com...

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Main Authors: Jia-Yuan Zhang, Hannah Roberts, David S C Flores, Antony J Cutler, Andrew C Brown, Justin P Whalley, Olga Mielczarek, David Buck, Helen Lockstone, Barbara Xella, Karen Oliver, Craig Corton, Emma Betteridge, Rachael Bashford-Rogers, Julian C Knight, John A Todd, Gavin Band
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-08-01
Series:PLoS Computational Biology
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8363018
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