Risk factors associated with complications and local tumour progression in image-guided triple-freezing cryoablation for lung tumour: a longitudinal study
Purpose This study aimed to investigate the efficacy of triple-freezing cryoablation, the temporal changes of ablation zones, and their association with local tumor progression in patients with lung malignancy.Methods This retrospective analysis included patients who underwent triple-freezing cryoab...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2025-12-01
|
| Series: | International Journal of Hyperthermia |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/02656736.2025.2492769 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Purpose This study aimed to investigate the efficacy of triple-freezing cryoablation, the temporal changes of ablation zones, and their association with local tumor progression in patients with lung malignancy.Methods This retrospective analysis included patients who underwent triple-freezing cryoablation for lung tumors between 2009 and 2017. The size, shape of the ablation zones, and procedure related complications were evaluated. Fine–Gray regression analysis was utilized to determine the risk factors associated with recurrence while considering mortality as a competing risk.Results The study included 41 patients, with 58 ablation sessions for 76 lesions. A tumor size >2 cm was associated with a higher rate of local tumor progression (subdistribution hazard ratio [SHR], 2.623, 95% CI, 1.126–6.107, p = 0.025). An ablation zone-tumor ratio ≥2 emerged as an independent predictor of less local tumor progression (SHR, 0.384, 95% confidence interval [CI]; 0.168–0.877; p = 0.023). There was a 1.7% incidence of adverse events classified as CTCAE (v5.0) grade 3 or higher. Patients without subsequent local tumor progression showed a greater decrease in the ablation zone minor axis at the 6 month-follow up computed tomography (CT) than those with recurrence (25.8% decrease [interquartile range (IQR), 10.3–47.5%] vs 2.4% decrease [IQR, −10.0–7.9%]; p = 0.004).Conclusion An ablation zone-tumor ratio of ≥2 was associated with less local tumor progression, and a smaller decrease in the ablation zone at the 6-month follow-up CT indicated a higher rate of subsequent local tumor progression. |
|---|---|
| ISSN: | 0265-6736 1464-5157 |