A Knowledge‐Guided Graph Learning Approach Bridging Phenotype‐ and Target‐Based Drug Discovery

A Knowledge‐Guided Graph Learning Approach Bridging Phenotype‐ and Target‐Based Drug Discovery

Abstract Discovering therapeutic molecules requires the integration of both phenotype‐based drug discovery (PDD) and target‐based drug discovery (TDD). However, this integration remains challenging due to the inherent heterogeneity, noise, and bias present in biomedical data. In this study, Knowledg...

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Bibliographic Details
Main Authors: Qing Ye, Yundian Zeng, Linlong Jiang, Yu Kang, Peichen Pan, Jiming Chen, Yafeng Deng, Haitao Zhao, Shibo He, Tingjun Hou, Chang‐Yu Hsieh
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:Advanced Science
Subjects:
biological networks
drug target discovery
graph representation learning
phenotypic screening
transcriptomics
Online Access:https://doi.org/10.1002/advs.202412402
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