Potential role of SIRT1 in cell ferroptosis
Ferroptosis is a novel form of cell death that uniquely requires iron and is characterized by iron accumulation, the generation of free radicals leading to oxidative stress, and the formation of lipid peroxides, which distinguish it from other forms of cell death. The regulation of ferroptosis is ex...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-03-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2025.1525294/full |
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| author | Yueming Zhang Fanxiao Kong Nan Li Lina Tao Jinghui Zhai Jie Ma Sixi Zhang |
| author_facet | Yueming Zhang Fanxiao Kong Nan Li Lina Tao Jinghui Zhai Jie Ma Sixi Zhang |
| author_sort | Yueming Zhang |
| collection | DOAJ |
| description | Ferroptosis is a novel form of cell death that uniquely requires iron and is characterized by iron accumulation, the generation of free radicals leading to oxidative stress, and the formation of lipid peroxides, which distinguish it from other forms of cell death. The regulation of ferroptosis is extremely complex and is closely associated with a spectrum of diseases. Sirtuin 1 (SIRT1), a NAD + -dependent histone deacetylase, has emerged as a pivotal epigenetic regulator with the potential to regulate ferroptosis through a wide array of genes intricately associated with lipid metabolism, iron homeostasis, glutathione biosynthesis, and redox homeostasis. This review provides a comprehensive overview of the specific mechanisms by which SIRT1 regulates ferroptosis and explores its potential therapeutic value in the context of multiple disease pathologies, highlighting the significance of SIRT1-mediated ferroptosis in treatment strategies. |
| format | Article |
| id | doaj-art-be9355d55e524d4d8ca302b02f2a781a |
| institution | OA Journals |
| issn | 2296-634X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj-art-be9355d55e524d4d8ca302b02f2a781a2025-08-20T02:02:25ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2025-03-011310.3389/fcell.2025.15252941525294Potential role of SIRT1 in cell ferroptosisYueming Zhang0Fanxiao Kong1Nan Li2Lina Tao3Jinghui Zhai4Jie Ma5Sixi Zhang6Department of Clinical Pharmacy, The First Hospital of Jilin University, Jilin, ChinaState Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Clinical Pharmacy, The First Hospital of Jilin University, Jilin, ChinaDepartment of Pharmacy, The First Hospital of Jilin University, Jilin, ChinaDepartment of Clinical Pharmacy, The First Hospital of Jilin University, Jilin, ChinaDepartment of Clinical Pharmacy, The First Hospital of Jilin University, Jilin, ChinaDepartment of Clinical Pharmacy, The First Hospital of Jilin University, Jilin, ChinaFerroptosis is a novel form of cell death that uniquely requires iron and is characterized by iron accumulation, the generation of free radicals leading to oxidative stress, and the formation of lipid peroxides, which distinguish it from other forms of cell death. The regulation of ferroptosis is extremely complex and is closely associated with a spectrum of diseases. Sirtuin 1 (SIRT1), a NAD + -dependent histone deacetylase, has emerged as a pivotal epigenetic regulator with the potential to regulate ferroptosis through a wide array of genes intricately associated with lipid metabolism, iron homeostasis, glutathione biosynthesis, and redox homeostasis. This review provides a comprehensive overview of the specific mechanisms by which SIRT1 regulates ferroptosis and explores its potential therapeutic value in the context of multiple disease pathologies, highlighting the significance of SIRT1-mediated ferroptosis in treatment strategies.https://www.frontiersin.org/articles/10.3389/fcell.2025.1525294/fullSIRT1ferroptosismolecular mechanismstherapeutic strategiesvarious diseases |
| spellingShingle | Yueming Zhang Fanxiao Kong Nan Li Lina Tao Jinghui Zhai Jie Ma Sixi Zhang Potential role of SIRT1 in cell ferroptosis Frontiers in Cell and Developmental Biology SIRT1 ferroptosis molecular mechanisms therapeutic strategies various diseases |
| title | Potential role of SIRT1 in cell ferroptosis |
| title_full | Potential role of SIRT1 in cell ferroptosis |
| title_fullStr | Potential role of SIRT1 in cell ferroptosis |
| title_full_unstemmed | Potential role of SIRT1 in cell ferroptosis |
| title_short | Potential role of SIRT1 in cell ferroptosis |
| title_sort | potential role of sirt1 in cell ferroptosis |
| topic | SIRT1 ferroptosis molecular mechanisms therapeutic strategies various diseases |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2025.1525294/full |
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