ER stress-driven unfolded protein response fuels aging-related tumor aggressiveness in gliomas

ER stress-driven unfolded protein response fuels aging-related tumor aggressiveness in gliomas

BackgroundGliomas are the most prevalent and aggressive primary brain tumors. Aging significantly influences glioma incidence and progression, yet the molecular mechanisms linking aging-related pathways to tumor aggressiveness remain poorly understood. Here, we aimed to decipher aging-related molecu...

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Bibliographic Details
Main Authors: Xiaodong Shao, Shaolei Guo, Jia Yang, Junjie Dai, Kaihua Cao, Xia Cai, Tianshi Song, Shun Yao, Umar Raza, Kun Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Molecular Biosciences
Subjects:
glioma
aging
tumor aggressiveness
ER stress
UPR
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2025.1640038/full
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