CAMKKβ supports growth and viability of epithelial ovarian cancer in vitro and in vivo

CAMKKβ supports growth and viability of epithelial ovarian cancer in vitro and in vivo

Abstract Epithelial ovarian cancer (EOC) metastasizes predominantly through multicellular aggregates known as spheroids, which disseminate within the peritoneal cavity and initiate secondary disease upon reattachment at distant sites. EOC spheroids resist detachment-induced cell death by upregulatin...

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Bibliographic Details
Main Authors: Matthew J. Borrelli, Adrian Buensuceso, Yudith Ramos Valdes, Tiffany P.A. Johnston, Jacob Haagsma, Trevor G. Shepherd
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Epithelial ovarian cancer
Spheroid
Metastasis
CAMKK2
AMPK
Autophagy
Online Access:https://doi.org/10.1038/s41598-025-11584-9
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