Metachronous liver metastases after long-term follow-up of endoscopic resection for rectal neuroendocrine neoplasms: a report of three cases
Abstract Background Rectal neuroendocrine neoplasms (NENs) are rare, but their incidence has increased in recent years. The metastasis rate is low in cases of a tumor diameter < 1 cm or depth of invasion lower than the submucosa; therefore, the European Neuroendocrine Tumor Society (ENETS) and th...
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Japan Surgical Society
2020-01-01
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| Series: | Surgical Case Reports |
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| Online Access: | https://doi.org/10.1186/s40792-020-0792-5 |
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| author | Yuma Hane Takahiro Tsuchikawa Kimitaka Tanaka Yoshitsugu Nakanishi Toshimichi Asano Takehiro Noji Yo Kurashima Yuma Ebihara Soichi Murakami Toru Nakamura Keisuke Okamura Satoshi Takeuchi Toshiaki Shichinohe Satoshi Hirano |
| author_facet | Yuma Hane Takahiro Tsuchikawa Kimitaka Tanaka Yoshitsugu Nakanishi Toshimichi Asano Takehiro Noji Yo Kurashima Yuma Ebihara Soichi Murakami Toru Nakamura Keisuke Okamura Satoshi Takeuchi Toshiaki Shichinohe Satoshi Hirano |
| author_sort | Yuma Hane |
| collection | DOAJ |
| description | Abstract Background Rectal neuroendocrine neoplasms (NENs) are rare, but their incidence has increased in recent years. The metastasis rate is low in cases of a tumor diameter < 1 cm or depth of invasion lower than the submucosa; therefore, the European Neuroendocrine Tumor Society (ENETS) and the North American Neuroendocrine Tumor Society (NANETS) consensus guidelines recommend endoscopic resection. Since little has been reported on the long-term prognosis of endoscopic resection for rectal NEN, consensus is lacking regarding the follow-up period after endoscopic resection. Case presentation Here, we report three cases of metachronous liver metastasis after long-term follow-up of endoscopic mucosal resection (EMR) for rectal NEN. The pathological findings indicated a depth lower than the submucosa and complete radical resection in all cases and lymphovascular invasion in only one case. All three cases showed metachronous multiple liver metastases after 9–13 years of follow-up for EMR, despite achieving complete resection and without muscular invasion. Conclusions Metachronous liver metastases may occur after long interval following endoscopic resection; thus, long-term follow-up is necessary after endoscopic resection for rectal NEN. |
| format | Article |
| id | doaj-art-be8465f784d74a368d0307d2f769405a |
| institution | DOAJ |
| issn | 2198-7793 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Japan Surgical Society |
| record_format | Article |
| series | Surgical Case Reports |
| spelling | doaj-art-be8465f784d74a368d0307d2f769405a2025-08-20T02:51:35ZengJapan Surgical SocietySurgical Case Reports2198-77932020-01-01611510.1186/s40792-020-0792-5Metachronous liver metastases after long-term follow-up of endoscopic resection for rectal neuroendocrine neoplasms: a report of three casesYuma Hane0Takahiro Tsuchikawa1Kimitaka Tanaka2Yoshitsugu Nakanishi3Toshimichi Asano4Takehiro Noji5Yo Kurashima6Yuma Ebihara7Soichi Murakami8Toru Nakamura9Keisuke Okamura10Satoshi Takeuchi11Toshiaki Shichinohe12Satoshi Hirano13Department of Gastroenterological Surgery II, Division of Surgery, Faculty of Medicine, Hokkaido UniversityDepartment of Gastroenterological Surgery II, Division of Surgery, Faculty of Medicine, Hokkaido UniversityDepartment of Gastroenterological Surgery II, Division of Surgery, Faculty of Medicine, Hokkaido UniversityDepartment of Gastroenterological Surgery II, Division of Surgery, Faculty of Medicine, Hokkaido UniversityDepartment of Gastroenterological Surgery II, Division of Surgery, Faculty of Medicine, Hokkaido UniversityDepartment of Gastroenterological Surgery II, Division of Surgery, Faculty of Medicine, Hokkaido UniversityDepartment of Gastroenterological Surgery II, Division of Surgery, Faculty of Medicine, Hokkaido UniversityDepartment of Gastroenterological Surgery II, Division of Surgery, Faculty of Medicine, Hokkaido UniversityDepartment of Gastroenterological Surgery II, Division of Surgery, Faculty of Medicine, Hokkaido UniversityDepartment of Gastroenterological Surgery II, Division of Surgery, Faculty of Medicine, Hokkaido UniversityDepartment of Gastroenterological Surgery II, Division of Surgery, Faculty of Medicine, Hokkaido UniversityDepartment of Medical Oncology, Graduate School of Medicine, Hokkaido UniversityDepartment of Gastroenterological Surgery II, Division of Surgery, Faculty of Medicine, Hokkaido UniversityDepartment of Gastroenterological Surgery II, Division of Surgery, Faculty of Medicine, Hokkaido UniversityAbstract Background Rectal neuroendocrine neoplasms (NENs) are rare, but their incidence has increased in recent years. The metastasis rate is low in cases of a tumor diameter < 1 cm or depth of invasion lower than the submucosa; therefore, the European Neuroendocrine Tumor Society (ENETS) and the North American Neuroendocrine Tumor Society (NANETS) consensus guidelines recommend endoscopic resection. Since little has been reported on the long-term prognosis of endoscopic resection for rectal NEN, consensus is lacking regarding the follow-up period after endoscopic resection. Case presentation Here, we report three cases of metachronous liver metastasis after long-term follow-up of endoscopic mucosal resection (EMR) for rectal NEN. The pathological findings indicated a depth lower than the submucosa and complete radical resection in all cases and lymphovascular invasion in only one case. All three cases showed metachronous multiple liver metastases after 9–13 years of follow-up for EMR, despite achieving complete resection and without muscular invasion. Conclusions Metachronous liver metastases may occur after long interval following endoscopic resection; thus, long-term follow-up is necessary after endoscopic resection for rectal NEN.https://doi.org/10.1186/s40792-020-0792-5Neuroendocrine neoplasmEndoscopic resectionLong-term follow-upRecurrence |
| spellingShingle | Yuma Hane Takahiro Tsuchikawa Kimitaka Tanaka Yoshitsugu Nakanishi Toshimichi Asano Takehiro Noji Yo Kurashima Yuma Ebihara Soichi Murakami Toru Nakamura Keisuke Okamura Satoshi Takeuchi Toshiaki Shichinohe Satoshi Hirano Metachronous liver metastases after long-term follow-up of endoscopic resection for rectal neuroendocrine neoplasms: a report of three cases Surgical Case Reports Neuroendocrine neoplasm Endoscopic resection Long-term follow-up Recurrence |
| title | Metachronous liver metastases after long-term follow-up of endoscopic resection for rectal neuroendocrine neoplasms: a report of three cases |
| title_full | Metachronous liver metastases after long-term follow-up of endoscopic resection for rectal neuroendocrine neoplasms: a report of three cases |
| title_fullStr | Metachronous liver metastases after long-term follow-up of endoscopic resection for rectal neuroendocrine neoplasms: a report of three cases |
| title_full_unstemmed | Metachronous liver metastases after long-term follow-up of endoscopic resection for rectal neuroendocrine neoplasms: a report of three cases |
| title_short | Metachronous liver metastases after long-term follow-up of endoscopic resection for rectal neuroendocrine neoplasms: a report of three cases |
| title_sort | metachronous liver metastases after long term follow up of endoscopic resection for rectal neuroendocrine neoplasms a report of three cases |
| topic | Neuroendocrine neoplasm Endoscopic resection Long-term follow-up Recurrence |
| url | https://doi.org/10.1186/s40792-020-0792-5 |
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