Harnessing gut microbiota for longevity: Insights into mechanisms and genetic manipulation
Abstract The gut microbiota is pivotal in maintaining health, with most microorganisms being beneficial, except for a few pathogens. Emerging evidence suggests a link between the gut microbiome and aging, hinting at its potential role in longevity. However, understanding the relationship is challeng...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2024-12-01
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| Series: | iMetaOmics |
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| Online Access: | https://doi.org/10.1002/imo2.36 |
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| _version_ | 1832575935490031616 |
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| author | Peng Shi Simin Xu Ziling Yang Liying Wang Yalun Wu Ying Li Zuobin Zhu |
| author_facet | Peng Shi Simin Xu Ziling Yang Liying Wang Yalun Wu Ying Li Zuobin Zhu |
| author_sort | Peng Shi |
| collection | DOAJ |
| description | Abstract The gut microbiota is pivotal in maintaining health, with most microorganisms being beneficial, except for a few pathogens. Emerging evidence suggests a link between the gut microbiome and aging, hinting at its potential role in longevity. However, understanding the relationship is challenging due to the microbiota's complexity. This perspective summarizes the mechanisms by which gut microbes regulate host lifespan and explores genetic manipulation strategies to promote healthy aging in the elderly. |
| format | Article |
| id | doaj-art-be83eef268b04b618eca0bc0a471b86b |
| institution | Kabale University |
| issn | 2996-9506 2996-9514 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | iMetaOmics |
| spelling | doaj-art-be83eef268b04b618eca0bc0a471b86b2025-01-31T16:15:24ZengWileyiMetaOmics2996-95062996-95142024-12-0112n/an/a10.1002/imo2.36Harnessing gut microbiota for longevity: Insights into mechanisms and genetic manipulationPeng Shi0Simin Xu1Ziling Yang2Liying Wang3Yalun Wu4Ying Li5Zuobin Zhu6Jiangsu Engineering Research Center for Precision Diagnosis and Treatment of Polygenic Critical Diseases, Key Laboratory of Genetic Foundation and Clinical Application, Department of Genetics Xuzhou Medical University Xuzhou ChinaDepartment of Biological Sciences, Faculty of Science National University of Singapore Singapore SingaporeJiangsu Engineering Research Center for Precision Diagnosis and Treatment of Polygenic Critical Diseases, Key Laboratory of Genetic Foundation and Clinical Application, Department of Genetics Xuzhou Medical University Xuzhou ChinaJiangsu Engineering Research Center for Precision Diagnosis and Treatment of Polygenic Critical Diseases, Key Laboratory of Genetic Foundation and Clinical Application, Department of Genetics Xuzhou Medical University Xuzhou ChinaJiangsu Engineering Research Center for Precision Diagnosis and Treatment of Polygenic Critical Diseases, Key Laboratory of Genetic Foundation and Clinical Application, Department of Genetics Xuzhou Medical University Xuzhou ChinaXuzhou Key Laboratory of Laboratory Diagnostics, Medical Technology College Xuzhou Medical University Xuzhou ChinaJiangsu Engineering Research Center for Precision Diagnosis and Treatment of Polygenic Critical Diseases, Key Laboratory of Genetic Foundation and Clinical Application, Department of Genetics Xuzhou Medical University Xuzhou ChinaAbstract The gut microbiota is pivotal in maintaining health, with most microorganisms being beneficial, except for a few pathogens. Emerging evidence suggests a link between the gut microbiome and aging, hinting at its potential role in longevity. However, understanding the relationship is challenging due to the microbiota's complexity. This perspective summarizes the mechanisms by which gut microbes regulate host lifespan and explores genetic manipulation strategies to promote healthy aging in the elderly.https://doi.org/10.1002/imo2.36aging pathwaysgut microbiotalongevitymetagenomic engineeringmicrobial metabolites |
| spellingShingle | Peng Shi Simin Xu Ziling Yang Liying Wang Yalun Wu Ying Li Zuobin Zhu Harnessing gut microbiota for longevity: Insights into mechanisms and genetic manipulation iMetaOmics aging pathways gut microbiota longevity metagenomic engineering microbial metabolites |
| title | Harnessing gut microbiota for longevity: Insights into mechanisms and genetic manipulation |
| title_full | Harnessing gut microbiota for longevity: Insights into mechanisms and genetic manipulation |
| title_fullStr | Harnessing gut microbiota for longevity: Insights into mechanisms and genetic manipulation |
| title_full_unstemmed | Harnessing gut microbiota for longevity: Insights into mechanisms and genetic manipulation |
| title_short | Harnessing gut microbiota for longevity: Insights into mechanisms and genetic manipulation |
| title_sort | harnessing gut microbiota for longevity insights into mechanisms and genetic manipulation |
| topic | aging pathways gut microbiota longevity metagenomic engineering microbial metabolites |
| url | https://doi.org/10.1002/imo2.36 |
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