Educing the toxicity of multimodal anesthesia components in cats with polytrauma
The impact of three-component multimodal anesthesia (Zoletil-Sevoflurane-Lidocaine – ZSL) on the body of cats with polytrauma was studied. An analysis was conducted on changes in heart rate (HR), respiratory rate (RR), body temperature, red and white blood cell count, hemoglobin content, and leukogr...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Stepan Gzhytskyi National University of Veterinary Medicine and Biotechnologies Lviv
2024-05-01
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| Series: | Науковий вісник Львівського національного університету ветеринарної медицини та біотехнологій імені С.З. Ґжицького: Серія Ветеринарні науки |
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| Online Access: | https://nvlvet.com.ua/index.php/journal/article/view/5178 |
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| Summary: | The impact of three-component multimodal anesthesia (Zoletil-Sevoflurane-Lidocaine – ZSL) on the body of cats with polytrauma was studied. An analysis was conducted on changes in heart rate (HR), respiratory rate (RR), body temperature, red and white blood cell count, hemoglobin content, and leukogram indices before and after ZS or ZSL anesthesia and 24 hours post-application in cats with multiple injuries. Two groups of cats (n = 6) with symptoms of polytrauma (without signs of massive internal bleeding and open fractures), weighing up to 3.5 kg, aged 2 to 3.5 years, were formed for controlled randomized studies. Cats in the control group received Zoletil-Sevoflurane (ZS), while the experimental group received ZSL. The dosage of Zoletil and Sevoflurane was administered according to approved instructions, and a 2 % lidocaine solution was administered intravenously along with a 0.9 % sodium chloride solution, calculated at 20 mcg/kg/hours for an injured cat. Clinical observation of animals in both groups was conducted continuously. Hematological studies were conducted before general anesthesia and 24 hours later. In the initial clinical study, the HR, RR, and body temperature indices were almost identical, confirming the same intensity of the pain syndrome. After 24 hours of applying multimodal anesthesia, the aforementioned average indices in the experimental group (received ZSL) were significantly (P ≤ 0.01) lower: HR 123.7 ± 1.4 bpm compared to 130.2 ± 1.2 bpm (ZS), RR 18.7 ± 0.2 breaths/min compared to 21.3 ± 0.6 breaths/min (ZS), attributed to the reduction of nociceptive pain intensity due to the pharmacological action of lidocaine hydrochloride. The average indices of red and white blood cell counts and hemoglobin content in cats upon admission to the veterinary clinic were identical and lower than reference values, explained by blood loss. In the experimental group (ZSL), after 24 hours, a significant (P ≤ 0.001) increase in hemoglobin (100.1 ± 0.65 g/l) was recorded compared to 91.7 ± 0.76 g/l (ZS) and a decrease in white blood cell count 19.4 ± 0.3 G/l (ZSL) compared to 30.5 ± 0.9 G/l (ZS). In the leukogram of cats additionally receiving lidocaine, a threefold increase in eosinophils (3 ± 0.63 % compared to 1 ± 0.36 % in the control), absence of juvenile neutrophils (1.3 ± 0.21 % in the control), significant (P ≤ 0.001) reduction in band neutrophils (18 ± 0.76 % compared to 31.3 ± 0.76 % – ZS), increase in lymphocytes (23.3 ± 1.1 % compared to 13.7 ± 0.21 % in the control), and increase in monocytes (20 ± 7 % compared to 10.7 ± 0.21 % in animals that received ZS) were recorded. This indicates enhanced phagocytosis and immune response in accidental injuries. Thus, the inclusion of lidocaine hydrochloride in the composition of multimodal general anesthesia for cats with polytrauma ensures the blocking of nociceptive receptors and stimulates reparative processes in damaged tissues. |
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| ISSN: | 2518-7554 2518-1327 |