Association of ANKRD55 Gene Polymorphism with HT: A Protective Factor for Disease Susceptibility
Purpose. Recent studies have shown that Ankyrin Repeat Domain 55 (ANKRD55) gene polymorphism is a risk factor for multiple autoimmune diseases, but its association with autoimmune thyroid diseases (AITDs) has not been reported. The purpose of this study was to investigate the potential relationship...
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| Format: | Article |
| Language: | English |
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Wiley
2022-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2022/7300796 |
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| author | Yu-die Fang Jing Zhao Xin-juan Zhuang Jian-bin Xu Tian-tian Cai Xiao-rong Yang Kai-da Mu Jin-an Zhang |
| author_facet | Yu-die Fang Jing Zhao Xin-juan Zhuang Jian-bin Xu Tian-tian Cai Xiao-rong Yang Kai-da Mu Jin-an Zhang |
| author_sort | Yu-die Fang |
| collection | DOAJ |
| description | Purpose. Recent studies have shown that Ankyrin Repeat Domain 55 (ANKRD55) gene polymorphism is a risk factor for multiple autoimmune diseases, but its association with autoimmune thyroid diseases (AITDs) has not been reported. The purpose of this study was to investigate the potential relationship between polymorphism of the ANKRD55 gene and AITDs. Methods. For this study, we enrolled 2050 subjects, consisting of 1220 patients with AITD and 830 healthy subjects. Five loci (rs321776, rs191205, rs7731626, rs415407, and rs159572) of the ANKRD55 gene were genotyped using Multiplex PCR combined with high-throughput sequencing. Results. The results showed that the allele frequencies of rs7731626 and rs159572 loci in HT patients were lower than those in normal controls (P=0.048 and P=0.03, respectively). In different genetic model analyses, rs7731626 and rs159572 were also significantly correlated with HT in allele, dominant and additive models before and after age and sex adjustment. There were no differences in rs321776, rs191205, or rs415407 of the ANKRD55 gene in allele frequency or genotype frequency between AITDs patients and controls. Conclusions. This study for the first time found that rs7731626 and rs159572 of ANKRD55 were significantly correlated with HT, and individuals carrying the A allele at these two loci had a lower probability of developing HT. |
| format | Article |
| id | doaj-art-be7ec35554ee4210a43e8644077d8358 |
| institution | Kabale University |
| issn | 1687-8345 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-be7ec35554ee4210a43e8644077d83582025-02-03T01:23:12ZengWileyInternational Journal of Endocrinology1687-83452022-01-01202210.1155/2022/7300796Association of ANKRD55 Gene Polymorphism with HT: A Protective Factor for Disease SusceptibilityYu-die Fang0Jing Zhao1Xin-juan Zhuang2Jian-bin Xu3Tian-tian Cai4Xiao-rong Yang5Kai-da Mu6Jin-an Zhang7Graduate SchoolDepartment of Endocrinology & RheumatologyDepartment of EndocrinologyDepartment of Endocrinology & RheumatologyDepartment of Endocrinology & RheumatologyDepartment of Endocrinology & RheumatologyDepartment of Endocrinology & RheumatologyDepartment of Endocrinology & RheumatologyPurpose. Recent studies have shown that Ankyrin Repeat Domain 55 (ANKRD55) gene polymorphism is a risk factor for multiple autoimmune diseases, but its association with autoimmune thyroid diseases (AITDs) has not been reported. The purpose of this study was to investigate the potential relationship between polymorphism of the ANKRD55 gene and AITDs. Methods. For this study, we enrolled 2050 subjects, consisting of 1220 patients with AITD and 830 healthy subjects. Five loci (rs321776, rs191205, rs7731626, rs415407, and rs159572) of the ANKRD55 gene were genotyped using Multiplex PCR combined with high-throughput sequencing. Results. The results showed that the allele frequencies of rs7731626 and rs159572 loci in HT patients were lower than those in normal controls (P=0.048 and P=0.03, respectively). In different genetic model analyses, rs7731626 and rs159572 were also significantly correlated with HT in allele, dominant and additive models before and after age and sex adjustment. There were no differences in rs321776, rs191205, or rs415407 of the ANKRD55 gene in allele frequency or genotype frequency between AITDs patients and controls. Conclusions. This study for the first time found that rs7731626 and rs159572 of ANKRD55 were significantly correlated with HT, and individuals carrying the A allele at these two loci had a lower probability of developing HT.http://dx.doi.org/10.1155/2022/7300796 |
| spellingShingle | Yu-die Fang Jing Zhao Xin-juan Zhuang Jian-bin Xu Tian-tian Cai Xiao-rong Yang Kai-da Mu Jin-an Zhang Association of ANKRD55 Gene Polymorphism with HT: A Protective Factor for Disease Susceptibility International Journal of Endocrinology |
| title | Association of ANKRD55 Gene Polymorphism with HT: A Protective Factor for Disease Susceptibility |
| title_full | Association of ANKRD55 Gene Polymorphism with HT: A Protective Factor for Disease Susceptibility |
| title_fullStr | Association of ANKRD55 Gene Polymorphism with HT: A Protective Factor for Disease Susceptibility |
| title_full_unstemmed | Association of ANKRD55 Gene Polymorphism with HT: A Protective Factor for Disease Susceptibility |
| title_short | Association of ANKRD55 Gene Polymorphism with HT: A Protective Factor for Disease Susceptibility |
| title_sort | association of ankrd55 gene polymorphism with ht a protective factor for disease susceptibility |
| url | http://dx.doi.org/10.1155/2022/7300796 |
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