Optical approaches for neurocritical care: Toward non-invasive recording of cerebral physiology in acute brain injury
Acute brain injury (ABI) is a complex disease process that begins with an initial insult followed by secondary injury resulting from disturbances in cerebral physiology. In the metabolically active brain, early recognition of physiologic derangements is critical in enabling clinicians with the insig...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Neurotherapeutics |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1878747924002071 |
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| author | Austen T. Lefebvre Nicole E. Steiner Carissa L. Rodriguez Joseph P. Angelo Eyal Bar-Kochba Rohan Mathur Marek Mirski David W. Blodgett |
| author_facet | Austen T. Lefebvre Nicole E. Steiner Carissa L. Rodriguez Joseph P. Angelo Eyal Bar-Kochba Rohan Mathur Marek Mirski David W. Blodgett |
| author_sort | Austen T. Lefebvre |
| collection | DOAJ |
| description | Acute brain injury (ABI) is a complex disease process that begins with an initial insult followed by secondary injury resulting from disturbances in cerebral physiology. In the metabolically active brain, early recognition of physiologic derangements is critical in enabling clinicians with the insight to adjust therapeutic interventions and reduce risk of ischemia and permanent injury. Current established approaches for monitoring cerebral physiology include the neurologic physical examination, traditional brain imaging such as computed tomography (CT) and magnetic resonance imaging (MRI), electroencephalography (EEG), and bedside modalities such as invasive parenchymal probes and transcranial doppler ultrasound. Diffuse optical spectroscopy (DOS), diffuse correlation spectroscopy (DCS), and optical coherence tomography (OCT) are non-invasive optical techniques that have shown promise in measuring clinically relevant changes in cerebral physiology. These new modalities may offer clinicians significant benefits as they are safe, can be utilized at the point-of-care, and provide continuous measurements. This paper reviews major causes of primary and secondary ABI encountered in neurocritical care units, conventional measures of cerebral physiology during ABI, and emerging non-invasive optical techniques that have significant potential for translation to the bedside. |
| format | Article |
| id | doaj-art-be76acd2c2c34cae8a4658395ce90158 |
| institution | Kabale University |
| issn | 1878-7479 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurotherapeutics |
| spelling | doaj-art-be76acd2c2c34cae8a4658395ce901582025-02-01T04:11:54ZengElsevierNeurotherapeutics1878-74792025-01-01221e00520Optical approaches for neurocritical care: Toward non-invasive recording of cerebral physiology in acute brain injuryAusten T. Lefebvre0Nicole E. Steiner1Carissa L. Rodriguez2Joseph P. Angelo3Eyal Bar-Kochba4Rohan Mathur5Marek Mirski6David W. Blodgett7Division of Neurosciences Critical Care, Departments of Neurology and Anesthesiology & Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USA; Corresponding author.John Hopkins University Applied Physics Laboratory, Laurel, MD, 20723, USAJohn Hopkins University Applied Physics Laboratory, Laurel, MD, 20723, USAJohn Hopkins University Applied Physics Laboratory, Laurel, MD, 20723, USAJohn Hopkins University Applied Physics Laboratory, Laurel, MD, 20723, USADivision of Neurosciences Critical Care, Departments of Neurology and Anesthesiology & Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USADivision of Neurosciences Critical Care, Departments of Neurology and Anesthesiology & Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, 21287, USAJohn Hopkins University Applied Physics Laboratory, Laurel, MD, 20723, USAAcute brain injury (ABI) is a complex disease process that begins with an initial insult followed by secondary injury resulting from disturbances in cerebral physiology. In the metabolically active brain, early recognition of physiologic derangements is critical in enabling clinicians with the insight to adjust therapeutic interventions and reduce risk of ischemia and permanent injury. Current established approaches for monitoring cerebral physiology include the neurologic physical examination, traditional brain imaging such as computed tomography (CT) and magnetic resonance imaging (MRI), electroencephalography (EEG), and bedside modalities such as invasive parenchymal probes and transcranial doppler ultrasound. Diffuse optical spectroscopy (DOS), diffuse correlation spectroscopy (DCS), and optical coherence tomography (OCT) are non-invasive optical techniques that have shown promise in measuring clinically relevant changes in cerebral physiology. These new modalities may offer clinicians significant benefits as they are safe, can be utilized at the point-of-care, and provide continuous measurements. This paper reviews major causes of primary and secondary ABI encountered in neurocritical care units, conventional measures of cerebral physiology during ABI, and emerging non-invasive optical techniques that have significant potential for translation to the bedside.http://www.sciencedirect.com/science/article/pii/S1878747924002071Acute brain injuryOptical monitoringCerebral physiologyNon-invasive optical recording |
| spellingShingle | Austen T. Lefebvre Nicole E. Steiner Carissa L. Rodriguez Joseph P. Angelo Eyal Bar-Kochba Rohan Mathur Marek Mirski David W. Blodgett Optical approaches for neurocritical care: Toward non-invasive recording of cerebral physiology in acute brain injury Neurotherapeutics Acute brain injury Optical monitoring Cerebral physiology Non-invasive optical recording |
| title | Optical approaches for neurocritical care: Toward non-invasive recording of cerebral physiology in acute brain injury |
| title_full | Optical approaches for neurocritical care: Toward non-invasive recording of cerebral physiology in acute brain injury |
| title_fullStr | Optical approaches for neurocritical care: Toward non-invasive recording of cerebral physiology in acute brain injury |
| title_full_unstemmed | Optical approaches for neurocritical care: Toward non-invasive recording of cerebral physiology in acute brain injury |
| title_short | Optical approaches for neurocritical care: Toward non-invasive recording of cerebral physiology in acute brain injury |
| title_sort | optical approaches for neurocritical care toward non invasive recording of cerebral physiology in acute brain injury |
| topic | Acute brain injury Optical monitoring Cerebral physiology Non-invasive optical recording |
| url | http://www.sciencedirect.com/science/article/pii/S1878747924002071 |
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