Surface functionalized mesoporous polydopamine nanocomposites for killing tumor cells through collaborative chemo/photothermal/chemodynamic treatment
Aim: The development of a collaborative strategy with improved efficacy holds great promise in tumor treatment. This study aims to develop an effective collaborative strategy based on functionalized mesoporous polydopamine (MPDA) nanocomposites for killing tumor cells. Methods: MPDA nanoparticles we...
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Open Exploration
2023-02-01
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| Series: | Exploration of Drug Science |
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| Online Access: | https://www.explorationpub.com/uploads/Article/A10083/10083.pdf |
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| author | Yi Ouyang Yan Chen Ting Xu Yihao Sun Sheng Zhao Chunmei Chen Yixin Tan Liang He Hui Liu |
| author_facet | Yi Ouyang Yan Chen Ting Xu Yihao Sun Sheng Zhao Chunmei Chen Yixin Tan Liang He Hui Liu |
| author_sort | Yi Ouyang |
| collection | DOAJ |
| description | Aim: The development of a collaborative strategy with improved efficacy holds great promise in tumor treatment. This study aims to develop an effective collaborative strategy based on functionalized mesoporous polydopamine (MPDA) nanocomposites for killing tumor cells. Methods: MPDA nanoparticles were synthesized and functionalized with camptothecin (CPT) payload and manganese dioxide (MnO2) coating to construct MPDA-CPT-MnO2 nanocomposites. Results: When uptaken by tumor cells, the nanocomposites can degrade to produce O2, release CPT, and generate manganese (Mn2+) under the stimulation of hydrogen peroxide (H2O2) and acid. The released CPT and Mn2+ can act as chemotherapeutic drug and Fenton-like agent, respectively. Abundant reactive oxygen species (ROS) are generated in 4T1 tumor cells through an Mn2+-mediated Fenton-like reaction. After that, the generated Mn4+ can react with glutathione (GSH) through redox reaction to produce Mn2+ and deplete GSH, disrupting the reducing capacity and benefiting the production of ROS in tumor cells. Under laser irradiation, the nanocomposites can generate hyperthermia to promote the production of ROS. Conclusions: The developed MPDA-CPT-MnO2 nanocomposites can kill tumor cells through collaborative chemo/photothermal/chemodynamic therapy (CDT). |
| format | Article |
| id | doaj-art-be73fe42d5074026a079a07573dc4d9f |
| institution | Kabale University |
| issn | 2836-7677 |
| language | English |
| publishDate | 2023-02-01 |
| publisher | Open Exploration |
| record_format | Article |
| series | Exploration of Drug Science |
| spelling | doaj-art-be73fe42d5074026a079a07573dc4d9f2025-02-08T05:16:46ZengOpen ExplorationExploration of Drug Science2836-76772023-02-011183010.37349/eds.2023.00003Surface functionalized mesoporous polydopamine nanocomposites for killing tumor cells through collaborative chemo/photothermal/chemodynamic treatmentYi Ouyang0Yan Chen1Ting Xu2Yihao Sun3Sheng Zhao4Chunmei Chen5Yixin Tan6Liang He7Hui Liu8https://orcid.org/0000-0002-7648-0915Key Laboratory of Luminescence Analysis and Molecular Sensing (Southwest University), Ministry of Education, School of Materials and Energy, Chongqing 400715, ChinaKey Laboratory of Luminescence Analysis and Molecular Sensing (Southwest University), Ministry of Education, School of Materials and Energy, Chongqing 400715, ChinaKey Laboratory of Luminescence Analysis and Molecular Sensing (Southwest University), Ministry of Education, School of Materials and Energy, Chongqing 400715, ChinaKey Laboratory of Luminescence Analysis and Molecular Sensing (Southwest University), Ministry of Education, School of Materials and Energy, Chongqing 400715, ChinaKey Laboratory of Luminescence Analysis and Molecular Sensing (Southwest University), Ministry of Education, School of Materials and Energy, Chongqing 400715, ChinaKey Laboratory of Luminescence Analysis and Molecular Sensing (Southwest University), Ministry of Education, School of Materials and Energy, Chongqing 400715, ChinaKey Laboratory of Luminescence Analysis and Molecular Sensing (Southwest University), Ministry of Education, School of Materials and Energy, Chongqing 400715, ChinaKey Laboratory of Luminescence Analysis and Molecular Sensing (Southwest University), Ministry of Education, School of Materials and Energy, Chongqing 400715, ChinaKey Laboratory of Luminescence Analysis and Molecular Sensing (Southwest University), Ministry of Education, School of Materials and Energy, Chongqing 400715, ChinaAim: The development of a collaborative strategy with improved efficacy holds great promise in tumor treatment. This study aims to develop an effective collaborative strategy based on functionalized mesoporous polydopamine (MPDA) nanocomposites for killing tumor cells. Methods: MPDA nanoparticles were synthesized and functionalized with camptothecin (CPT) payload and manganese dioxide (MnO2) coating to construct MPDA-CPT-MnO2 nanocomposites. Results: When uptaken by tumor cells, the nanocomposites can degrade to produce O2, release CPT, and generate manganese (Mn2+) under the stimulation of hydrogen peroxide (H2O2) and acid. The released CPT and Mn2+ can act as chemotherapeutic drug and Fenton-like agent, respectively. Abundant reactive oxygen species (ROS) are generated in 4T1 tumor cells through an Mn2+-mediated Fenton-like reaction. After that, the generated Mn4+ can react with glutathione (GSH) through redox reaction to produce Mn2+ and deplete GSH, disrupting the reducing capacity and benefiting the production of ROS in tumor cells. Under laser irradiation, the nanocomposites can generate hyperthermia to promote the production of ROS. Conclusions: The developed MPDA-CPT-MnO2 nanocomposites can kill tumor cells through collaborative chemo/photothermal/chemodynamic therapy (CDT).https://www.explorationpub.com/uploads/Article/A10083/10083.pdfmesoporous polydopaminechemotherapyphotothermal therapychemodynamic therapytumor treatment |
| spellingShingle | Yi Ouyang Yan Chen Ting Xu Yihao Sun Sheng Zhao Chunmei Chen Yixin Tan Liang He Hui Liu Surface functionalized mesoporous polydopamine nanocomposites for killing tumor cells through collaborative chemo/photothermal/chemodynamic treatment Exploration of Drug Science mesoporous polydopamine chemotherapy photothermal therapy chemodynamic therapy tumor treatment |
| title | Surface functionalized mesoporous polydopamine nanocomposites for killing tumor cells through collaborative chemo/photothermal/chemodynamic treatment |
| title_full | Surface functionalized mesoporous polydopamine nanocomposites for killing tumor cells through collaborative chemo/photothermal/chemodynamic treatment |
| title_fullStr | Surface functionalized mesoporous polydopamine nanocomposites for killing tumor cells through collaborative chemo/photothermal/chemodynamic treatment |
| title_full_unstemmed | Surface functionalized mesoporous polydopamine nanocomposites for killing tumor cells through collaborative chemo/photothermal/chemodynamic treatment |
| title_short | Surface functionalized mesoporous polydopamine nanocomposites for killing tumor cells through collaborative chemo/photothermal/chemodynamic treatment |
| title_sort | surface functionalized mesoporous polydopamine nanocomposites for killing tumor cells through collaborative chemo photothermal chemodynamic treatment |
| topic | mesoporous polydopamine chemotherapy photothermal therapy chemodynamic therapy tumor treatment |
| url | https://www.explorationpub.com/uploads/Article/A10083/10083.pdf |
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