High Detection Rate of Rotavirus Infection Among Children Admitted with Acute Gastroenteritis to Six Public Hospitals in Luanda Province After the Introduction of Rotarix<sup>®</sup> Vaccine: A Cross-Sectional Study
Rotavirus group A (RVA) is a major cause of pediatric acute gastroenteritis (AGE). Vaccination is an effective public health strategy and Angola implemented it in 2014. This hospital-based study aimed to estimate the prevalence of RVA infection and the severity of AGE in children under five years of...
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2024-12-01
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| author | Dikudila Vita Manuel Lemos Zoraima Neto Mathebula Evans Ngiambudulu M. Francisco Filomeno Fortes Ema Fernandes Celso Cunha Claudia Istrate |
| author_facet | Dikudila Vita Manuel Lemos Zoraima Neto Mathebula Evans Ngiambudulu M. Francisco Filomeno Fortes Ema Fernandes Celso Cunha Claudia Istrate |
| author_sort | Dikudila Vita |
| collection | DOAJ |
| description | Rotavirus group A (RVA) is a major cause of pediatric acute gastroenteritis (AGE). Vaccination is an effective public health strategy and Angola implemented it in 2014. This hospital-based study aimed to estimate the prevalence of RVA infection and the severity of AGE in children under five years of age treated at six hospitals in Luanda Province. Between April 2021 and May 2022, 1251 fecal samples were screened by an immunochromatographic rapid test (SD Bioline). Data on socio-demographic profile, nutritional status, and clinical assessment were obtained. The association of RVA infection and AGE severity with possible risk factors was evaluated with a binary logistic regression model. Overall, the detection rate was 57.8% and girls tend to be more often infected than boys (55.2%). Infection was more common in the youngest group (1 to 6 months, 60.3%). Important sources of RVA infection were drinking water kept in tanks (57.9%) and private sanitary facilities with piped water (61%). Surprisingly, according to the Vesikari Scale score, the most severe symptoms were observed in children vaccinated with two doses (80.7%). RVA prevalence remains high despite vaccination, and further studies should address the association between infection sources and disease severity, as well as the causes underlying vaccine (un)effectiveness. |
| format | Article |
| id | doaj-art-be6faccdd30942c487bade6948426751 |
| institution | DOAJ |
| issn | 1999-4915 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj-art-be6faccdd30942c487bade69484267512025-08-20T02:56:55ZengMDPI AGViruses1999-49152024-12-011612194910.3390/v16121949High Detection Rate of Rotavirus Infection Among Children Admitted with Acute Gastroenteritis to Six Public Hospitals in Luanda Province After the Introduction of Rotarix<sup>®</sup> Vaccine: A Cross-Sectional StudyDikudila Vita0Manuel Lemos1Zoraima Neto2Mathebula Evans3Ngiambudulu M. Francisco4Filomeno Fortes5Ema Fernandes6Celso Cunha7Claudia Istrate8Faculty of Medicine, Agostinho Neto University, Luanda P.O. Box 116, AngolaFaculty of Medicine, Agostinho Neto University, Luanda P.O. Box 116, AngolaNational Institute for Health Research, Luanda P.O. Box 3635, AngolaSchool of Health Systems and Public Health, Faculty of Health Science, University of Pretoria, Pretoria 0084, South AfricaNational Institute for Health Research, Luanda P.O. Box 3635, AngolaGlobal Health and Tropical Medicine (GHTM), Institute of Hygiene and Tropical Medicine (IHMT), NOVA University (UNL), 1349-008 Lisbon, PortugalFaculty of Medicine, Agostinho Neto University, Luanda P.O. Box 116, AngolaGlobal Health and Tropical Medicine (GHTM), Institute of Hygiene and Tropical Medicine (IHMT), NOVA University (UNL), 1349-008 Lisbon, PortugalAssociate Laboratory for Animal and Veterinary Sciences (AL4AnimalS), Interdisciplinary Center for Research in Animal Health (CIISA), Faculty of Veterinary Medicine, University of Lisbon, 1300-477 Lisbon, PortugalRotavirus group A (RVA) is a major cause of pediatric acute gastroenteritis (AGE). Vaccination is an effective public health strategy and Angola implemented it in 2014. This hospital-based study aimed to estimate the prevalence of RVA infection and the severity of AGE in children under five years of age treated at six hospitals in Luanda Province. Between April 2021 and May 2022, 1251 fecal samples were screened by an immunochromatographic rapid test (SD Bioline). Data on socio-demographic profile, nutritional status, and clinical assessment were obtained. The association of RVA infection and AGE severity with possible risk factors was evaluated with a binary logistic regression model. Overall, the detection rate was 57.8% and girls tend to be more often infected than boys (55.2%). Infection was more common in the youngest group (1 to 6 months, 60.3%). Important sources of RVA infection were drinking water kept in tanks (57.9%) and private sanitary facilities with piped water (61%). Surprisingly, according to the Vesikari Scale score, the most severe symptoms were observed in children vaccinated with two doses (80.7%). RVA prevalence remains high despite vaccination, and further studies should address the association between infection sources and disease severity, as well as the causes underlying vaccine (un)effectiveness.https://www.mdpi.com/1999-4915/16/12/1949rotavirusacute gastroenteritischildrenvaccineLuanda, Angola |
| spellingShingle | Dikudila Vita Manuel Lemos Zoraima Neto Mathebula Evans Ngiambudulu M. Francisco Filomeno Fortes Ema Fernandes Celso Cunha Claudia Istrate High Detection Rate of Rotavirus Infection Among Children Admitted with Acute Gastroenteritis to Six Public Hospitals in Luanda Province After the Introduction of Rotarix<sup>®</sup> Vaccine: A Cross-Sectional Study Viruses rotavirus acute gastroenteritis children vaccine Luanda, Angola |
| title | High Detection Rate of Rotavirus Infection Among Children Admitted with Acute Gastroenteritis to Six Public Hospitals in Luanda Province After the Introduction of Rotarix<sup>®</sup> Vaccine: A Cross-Sectional Study |
| title_full | High Detection Rate of Rotavirus Infection Among Children Admitted with Acute Gastroenteritis to Six Public Hospitals in Luanda Province After the Introduction of Rotarix<sup>®</sup> Vaccine: A Cross-Sectional Study |
| title_fullStr | High Detection Rate of Rotavirus Infection Among Children Admitted with Acute Gastroenteritis to Six Public Hospitals in Luanda Province After the Introduction of Rotarix<sup>®</sup> Vaccine: A Cross-Sectional Study |
| title_full_unstemmed | High Detection Rate of Rotavirus Infection Among Children Admitted with Acute Gastroenteritis to Six Public Hospitals in Luanda Province After the Introduction of Rotarix<sup>®</sup> Vaccine: A Cross-Sectional Study |
| title_short | High Detection Rate of Rotavirus Infection Among Children Admitted with Acute Gastroenteritis to Six Public Hospitals in Luanda Province After the Introduction of Rotarix<sup>®</sup> Vaccine: A Cross-Sectional Study |
| title_sort | high detection rate of rotavirus infection among children admitted with acute gastroenteritis to six public hospitals in luanda province after the introduction of rotarix sup r sup vaccine a cross sectional study |
| topic | rotavirus acute gastroenteritis children vaccine Luanda, Angola |
| url | https://www.mdpi.com/1999-4915/16/12/1949 |
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