Evaluation of Radius Fracture Repair With Critical-Sized Bone Defects Using Polypropylene Surgical Mesh in Rats
Bone fractures involving critical-sized defects pose a significant challenge in orthopedic surgery, often requiring innovative strategies to promote bone regeneration. This study aimed to evaluate the effectiveness of polypropylene surgical mesh in repairing critical-sized radius bone defects in a r...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Advances in Orthopedics |
| Online Access: | http://dx.doi.org/10.1155/aort/7262524 |
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| author | Asrin Emami Seyed Hadi Kalantar Asma Mafhumi Hiva Saffar Iman Menbari Oskouie |
| author_facet | Asrin Emami Seyed Hadi Kalantar Asma Mafhumi Hiva Saffar Iman Menbari Oskouie |
| author_sort | Asrin Emami |
| collection | DOAJ |
| description | Bone fractures involving critical-sized defects pose a significant challenge in orthopedic surgery, often requiring innovative strategies to promote bone regeneration. This study aimed to evaluate the effectiveness of polypropylene surgical mesh in repairing critical-sized radius bone defects in a rat model. Treatments included autologous grafts and a combination of mesh and graft, compared with an untreated control group. After 6 weeks, X-ray and CT scan analyses revealed significant bone healing and callus formation in the treated groups, with the graft + mesh group showing the most pronounced improvement. Histomorphometric analyses demonstrated that the mesh scaffold significantly enhanced new bone formation, osteoblast and osteocyte counts, and bone microarchitecture compared with grafts alone. These findings suggest that mesh scaffolds offer superior osteogenic potential and could provide a promising adjunct for treating critical-sized bone defects. Future studies should explore optimized mesh designs and the interplay between osteogenesis and angiogenesis to improve clinical outcomes. |
| format | Article |
| id | doaj-art-be6cdb2edabc4ac8a765ac4049dffc87 |
| institution | OA Journals |
| issn | 2090-3472 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advances in Orthopedics |
| spelling | doaj-art-be6cdb2edabc4ac8a765ac4049dffc872025-08-20T02:33:09ZengWileyAdvances in Orthopedics2090-34722025-01-01202510.1155/aort/7262524Evaluation of Radius Fracture Repair With Critical-Sized Bone Defects Using Polypropylene Surgical Mesh in RatsAsrin Emami0Seyed Hadi Kalantar1Asma Mafhumi2Hiva Saffar3Iman Menbari Oskouie4Iranian Tissue Bank and Research CenterJoint Reconstruction Research CenterCenter for Orthopedic Trans-Disciplinary Applied ResearchDepartment of Clinical PathologyUrology Research CenterBone fractures involving critical-sized defects pose a significant challenge in orthopedic surgery, often requiring innovative strategies to promote bone regeneration. This study aimed to evaluate the effectiveness of polypropylene surgical mesh in repairing critical-sized radius bone defects in a rat model. Treatments included autologous grafts and a combination of mesh and graft, compared with an untreated control group. After 6 weeks, X-ray and CT scan analyses revealed significant bone healing and callus formation in the treated groups, with the graft + mesh group showing the most pronounced improvement. Histomorphometric analyses demonstrated that the mesh scaffold significantly enhanced new bone formation, osteoblast and osteocyte counts, and bone microarchitecture compared with grafts alone. These findings suggest that mesh scaffolds offer superior osteogenic potential and could provide a promising adjunct for treating critical-sized bone defects. Future studies should explore optimized mesh designs and the interplay between osteogenesis and angiogenesis to improve clinical outcomes.http://dx.doi.org/10.1155/aort/7262524 |
| spellingShingle | Asrin Emami Seyed Hadi Kalantar Asma Mafhumi Hiva Saffar Iman Menbari Oskouie Evaluation of Radius Fracture Repair With Critical-Sized Bone Defects Using Polypropylene Surgical Mesh in Rats Advances in Orthopedics |
| title | Evaluation of Radius Fracture Repair With Critical-Sized Bone Defects Using Polypropylene Surgical Mesh in Rats |
| title_full | Evaluation of Radius Fracture Repair With Critical-Sized Bone Defects Using Polypropylene Surgical Mesh in Rats |
| title_fullStr | Evaluation of Radius Fracture Repair With Critical-Sized Bone Defects Using Polypropylene Surgical Mesh in Rats |
| title_full_unstemmed | Evaluation of Radius Fracture Repair With Critical-Sized Bone Defects Using Polypropylene Surgical Mesh in Rats |
| title_short | Evaluation of Radius Fracture Repair With Critical-Sized Bone Defects Using Polypropylene Surgical Mesh in Rats |
| title_sort | evaluation of radius fracture repair with critical sized bone defects using polypropylene surgical mesh in rats |
| url | http://dx.doi.org/10.1155/aort/7262524 |
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