Multiple sclerosis: a practical review for pathologists
Multiple sclerosis (MS) is an immune-mediated demyelinating disorder of the central nervous system. It is a chronic disorder resulting in neurologic dysfunction that is disseminated both in time (multiple discrete episodes) and space (involving multiple sites). Histologically, MS is characterized by...
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| Format: | Article |
| Language: | English |
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Korean Society of Pathologists & the Korean Society for Cytopathology
2025-07-01
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| Series: | Journal of Pathology and Translational Medicine |
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| Online Access: | http://www.jpatholtm.org/upload/pdf/jptm-2025-05-20.pdf |
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| _version_ | 1849716307754221568 |
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| author | Rachel A. Multz Pouya Jamshidi Jared T. Ahrendsen |
| author_facet | Rachel A. Multz Pouya Jamshidi Jared T. Ahrendsen |
| author_sort | Rachel A. Multz |
| collection | DOAJ |
| description | Multiple sclerosis (MS) is an immune-mediated demyelinating disorder of the central nervous system. It is a chronic disorder resulting in neurologic dysfunction that is disseminated both in time (multiple discrete episodes) and space (involving multiple sites). Histologically, MS is characterized by localized loss of myelin with relative preservation of axons. This review will discuss the epidemiology, clinical, laboratory, radiologic, and pathologic features of multiple sclerosis, as well as briefly touch on the differential diagnosis, treatment, and prognosis of the disease, especially as they relate to the pathologic interpretation of tissue specimens. |
| format | Article |
| id | doaj-art-be69aa3ea8dc49889ca784ffc982e988 |
| institution | DOAJ |
| issn | 2383-7837 2383-7845 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Korean Society of Pathologists & the Korean Society for Cytopathology |
| record_format | Article |
| series | Journal of Pathology and Translational Medicine |
| spelling | doaj-art-be69aa3ea8dc49889ca784ffc982e9882025-08-20T03:13:03ZengKorean Society of Pathologists & the Korean Society for CytopathologyJournal of Pathology and Translational Medicine2383-78372383-78452025-07-0159420321310.4132/jptm.2025.05.2017162Multiple sclerosis: a practical review for pathologistsRachel A. Multz0Pouya Jamshidi1Jared T. Ahrendsen Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USAMultiple sclerosis (MS) is an immune-mediated demyelinating disorder of the central nervous system. It is a chronic disorder resulting in neurologic dysfunction that is disseminated both in time (multiple discrete episodes) and space (involving multiple sites). Histologically, MS is characterized by localized loss of myelin with relative preservation of axons. This review will discuss the epidemiology, clinical, laboratory, radiologic, and pathologic features of multiple sclerosis, as well as briefly touch on the differential diagnosis, treatment, and prognosis of the disease, especially as they relate to the pathologic interpretation of tissue specimens.http://www.jpatholtm.org/upload/pdf/jptm-2025-05-20.pdfmultiple sclerosisdemyelinationneuropathology |
| spellingShingle | Rachel A. Multz Pouya Jamshidi Jared T. Ahrendsen Multiple sclerosis: a practical review for pathologists Journal of Pathology and Translational Medicine multiple sclerosis demyelination neuropathology |
| title | Multiple sclerosis: a practical review for pathologists |
| title_full | Multiple sclerosis: a practical review for pathologists |
| title_fullStr | Multiple sclerosis: a practical review for pathologists |
| title_full_unstemmed | Multiple sclerosis: a practical review for pathologists |
| title_short | Multiple sclerosis: a practical review for pathologists |
| title_sort | multiple sclerosis a practical review for pathologists |
| topic | multiple sclerosis demyelination neuropathology |
| url | http://www.jpatholtm.org/upload/pdf/jptm-2025-05-20.pdf |
| work_keys_str_mv | AT rachelamultz multiplesclerosisapracticalreviewforpathologists AT pouyajamshidi multiplesclerosisapracticalreviewforpathologists AT jaredtahrendsen multiplesclerosisapracticalreviewforpathologists |