Host and bacterial urine proteomics might predict treatment outcomes for immunotherapy in advanced non-small cell lung cancer patients

Host and bacterial urine proteomics might predict treatment outcomes for immunotherapy in advanced non-small cell lung cancer patients

IntroductionUrine samples are non-invasive approaches to study potential circulating biomarkers from the host organism. Specific proteins cross the bloodstream through the intestinal barrier and may also derive from gut microbiota. In this study, we aimed to evaluate the predictive role of the host...

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Main Authors: David Dora, Peter Revisnyei, Alija Pasic, Gabriella Galffy, Edit Dulka, Anna Mihucz, Brigitta Roskó, Sara Szincsak, Anton Iliuk, Glen J. Weiss, Zoltan Lohinai
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Immunology
Subjects:
NSCLC
immunotherapy
gut microbiome
EV protein
urine proteome
machine learning
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1543817/full
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