Gastric Cancer Mortality in Ceará in Brazil’s Northeastern, 2000-2022: Spatio- Temporal Study
Introduction: In recent decades, the prevalence of gastric cancer (GC) has increased in Brazil’s Northeastern, especially in the state of Ceará. Objective: To analyze temporal trends and spatial patterns of GC mortality over a 23-year period in Ceará. Method: All registered death certificates (DC)...
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Instituto Nacional de Câncer (INCA)
2025-07-01
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| Series: | Revista Brasileira de Cancerologia |
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| Online Access: | https://rbc.inca.gov.br/index.php/revista/article/view/5266 |
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| author | Lucia Libanez Bessa Campelo Braga Helio De Almeida Nobre Junior Jorg Heukelbach Anderson Fuentes Ferreira Ana Suzete Lopes Edson Luiz de Oliveira Vitor de Sousa Tomé Taynara Lais Silva Daniele Calheiros Campelo Maia Alberto Novaes Ramos Júnior |
| author_facet | Lucia Libanez Bessa Campelo Braga Helio De Almeida Nobre Junior Jorg Heukelbach Anderson Fuentes Ferreira Ana Suzete Lopes Edson Luiz de Oliveira Vitor de Sousa Tomé Taynara Lais Silva Daniele Calheiros Campelo Maia Alberto Novaes Ramos Júnior |
| author_sort | Lucia Libanez Bessa Campelo Braga |
| collection | DOAJ |
| description |
Introduction: In recent decades, the prevalence of gastric cancer (GC) has increased in Brazil’s Northeastern, especially in the state of Ceará. Objective: To analyze temporal trends and spatial patterns of GC mortality over a 23-year period in Ceará. Method: All registered death certificates (DC) (GC registered as any cause of death) from 2000 to 2022 were included. Temporal trends were assessed by joinpoint regression models, while spatial patterns were assessed by spatial autocorrelation, using the local Moran index based on Local Indicators of Spatial Association (LISA). Results: GC was detected in 16,670 DCs (1.5% of all deaths). Age- and sex-adjusted mortality was 8.44/100,000 population. The highest mortality rates were found in the southern parts of the state and around a northern major urban center. Analysis over time showed a rising trend (Average Annual Percent Change: AAPC 1.2; 95%CI 0.6;2.1), especially in males (AAPC 1.6; 95%CI 1.1;2.1), individuals <45 years (AAPC 2.1;3.7), residents of the central region (AAPC 3.2, 95%CI 1.8;5.1) and high deprivation index municipalities (AAPC 2.6, 95%CI 1.3;5.0). Spatial-temporal clusters of high risk for GC-related mortality from 2000 to 2017 were identified, with no statistical significance in the period 2018-2022: clusters were identified in the south until 2011 and in the northwest from 2006 to 2017. Conclusion: GC mortality has increased in Ceará during the study period. High risk areas for GC mortality were identified, enabling focused integrated actions to strengthen prevention, diagnosis, surveillance and control networks.
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| format | Article |
| id | doaj-art-be5f58df4b094b259e8832b9748846e2 |
| institution | Kabale University |
| issn | 0034-7116 2176-9745 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Instituto Nacional de Câncer (INCA) |
| record_format | Article |
| series | Revista Brasileira de Cancerologia |
| spelling | doaj-art-be5f58df4b094b259e8832b9748846e22025-08-20T03:30:44ZengInstituto Nacional de Câncer (INCA)Revista Brasileira de Cancerologia0034-71162176-97452025-07-0171310.32635/2176-9745.RBC.2025v71n3.5266Gastric Cancer Mortality in Ceará in Brazil’s Northeastern, 2000-2022: Spatio- Temporal StudyLucia Libanez Bessa Campelo Braga0Helio De Almeida Nobre Junior 1Jorg Heukelbach 2Anderson Fuentes Ferreira3Ana Suzete Lopes 4Edson Luiz de Oliveira5Vitor de Sousa Tomé 6Taynara Lais Silva7Daniele Calheiros Campelo Maia 8Alberto Novaes Ramos Júnior9Universidade Federal do Ceará (UFC), Faculdade de Medicina, Departamento de Clínica Médica, Programa de Pós-Graduação em Ciências Médico-Cirúrgicas. Fortaleza (CE), Brasil.Universidade Federal do Ceará (UFC), Faculdade de Medicina, Programa de Pós-Graduação em Ciências Médico-Cirúrgicas. Fortaleza (CE), Brasil.Universidade Federal do Ceará (UFC), Faculdade de Medicina, Programa de Pós-Graduação em Saúde Coletiva. Fortaleza (CE), BrasilUniversidade Federal do Ceará (UFC), Faculdade de Medicina, Programa de Pós-Graduação em Saúde Coletiva. Fortaleza (CE), Brasil. Universidade Federal do Ceará (UFC), Faculdade de Medicina, Programa de Pós-Graduação em Ciências Médico-Cirúrgicas. Fortaleza (CE), Brasil.Universidade Federal do Ceará (UFC), Faculdade de Medicina, Programa de Pós-Graduação em Ciências Médico-Cirúrgicas. Fortaleza (CE), Brasil.Universidade Federal do Ceará (UFC), Faculdade de Medicina, Programa de Pós-Graduação em Ciências Médico-Cirúrgicas. Fortaleza (CE), Brasil.Postgraduate Program of Public Health, School of Medicine, Federal University of Ceará, Fortaleza, Ceará, BrazilUniversidade Federal do Ceará (UFC), Faculdade de Medicina, Programa de Pós-Graduação em Ciências Médico-Cirúrgicas. Fortaleza (CE), Brasil.Universidade Federal do Ceará (UFC), Faculdade de Medicina, Departamento de Saúde Comunitária, Programa de Pós-Graduação em Saúde Coletiva. Fortaleza (CE), Brasil. Introduction: In recent decades, the prevalence of gastric cancer (GC) has increased in Brazil’s Northeastern, especially in the state of Ceará. Objective: To analyze temporal trends and spatial patterns of GC mortality over a 23-year period in Ceará. Method: All registered death certificates (DC) (GC registered as any cause of death) from 2000 to 2022 were included. Temporal trends were assessed by joinpoint regression models, while spatial patterns were assessed by spatial autocorrelation, using the local Moran index based on Local Indicators of Spatial Association (LISA). Results: GC was detected in 16,670 DCs (1.5% of all deaths). Age- and sex-adjusted mortality was 8.44/100,000 population. The highest mortality rates were found in the southern parts of the state and around a northern major urban center. Analysis over time showed a rising trend (Average Annual Percent Change: AAPC 1.2; 95%CI 0.6;2.1), especially in males (AAPC 1.6; 95%CI 1.1;2.1), individuals <45 years (AAPC 2.1;3.7), residents of the central region (AAPC 3.2, 95%CI 1.8;5.1) and high deprivation index municipalities (AAPC 2.6, 95%CI 1.3;5.0). Spatial-temporal clusters of high risk for GC-related mortality from 2000 to 2017 were identified, with no statistical significance in the period 2018-2022: clusters were identified in the south until 2011 and in the northwest from 2006 to 2017. Conclusion: GC mortality has increased in Ceará during the study period. High risk areas for GC mortality were identified, enabling focused integrated actions to strengthen prevention, diagnosis, surveillance and control networks. https://rbc.inca.gov.br/index.php/revista/article/view/5266 Stomach Neoplasms/epidemiologyDemography/trendsSpatial AnalysisEpidemiology/trendsMortality/trends |
| spellingShingle | Lucia Libanez Bessa Campelo Braga Helio De Almeida Nobre Junior Jorg Heukelbach Anderson Fuentes Ferreira Ana Suzete Lopes Edson Luiz de Oliveira Vitor de Sousa Tomé Taynara Lais Silva Daniele Calheiros Campelo Maia Alberto Novaes Ramos Júnior Gastric Cancer Mortality in Ceará in Brazil’s Northeastern, 2000-2022: Spatio- Temporal Study Revista Brasileira de Cancerologia Stomach Neoplasms/epidemiology Demography/trends Spatial Analysis Epidemiology/trends Mortality/trends |
| title | Gastric Cancer Mortality in Ceará in Brazil’s Northeastern, 2000-2022: Spatio- Temporal Study |
| title_full | Gastric Cancer Mortality in Ceará in Brazil’s Northeastern, 2000-2022: Spatio- Temporal Study |
| title_fullStr | Gastric Cancer Mortality in Ceará in Brazil’s Northeastern, 2000-2022: Spatio- Temporal Study |
| title_full_unstemmed | Gastric Cancer Mortality in Ceará in Brazil’s Northeastern, 2000-2022: Spatio- Temporal Study |
| title_short | Gastric Cancer Mortality in Ceará in Brazil’s Northeastern, 2000-2022: Spatio- Temporal Study |
| title_sort | gastric cancer mortality in ceara in brazil s northeastern 2000 2022 spatio temporal study |
| topic | Stomach Neoplasms/epidemiology Demography/trends Spatial Analysis Epidemiology/trends Mortality/trends |
| url | https://rbc.inca.gov.br/index.php/revista/article/view/5266 |
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