Integrated Analysis of Single-Cell and Bulk RNA-Sequencing Based on EcoTyper Machine Learning Framework Identifies Cell-State-Specific M2 Macrophage Markers Associated with Gastric Cancer Prognosis

A-Kao Zhu,1,* Guang-Yao Li,2,* Fang-Ci Chen,3 Jia-Qi Shan,3 Yu-Qiang Shan,3,4 Chen-Xi Lv,3 Zhi-Qiang Zhu,5 Yi-Ren He,5 Lu-Lu Zhai5 1Department of Colorectal Surgery and Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, People’s Republ...

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Main Authors: Zhu AK, Li GY, Chen FC, Shan JQ, Shan YQ, Lv CX, Zhu ZQ, He YR, Zhai LL
Format: Article
Language:English
Published: Dove Medical Press 2024-12-01
Series:ImmunoTargets and Therapy
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Online Access:https://www.dovepress.com/integrated-analysis-of-single-cell-and-bulk-rna-sequencing-based-on-ec-peer-reviewed-fulltext-article-ITT
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author Zhu AK
Li GY
Chen FC
Shan JQ
Shan YQ
Lv CX
Zhu ZQ
He YR
Zhai LL
author_facet Zhu AK
Li GY
Chen FC
Shan JQ
Shan YQ
Lv CX
Zhu ZQ
He YR
Zhai LL
author_sort Zhu AK
collection DOAJ
description A-Kao Zhu,1,* Guang-Yao Li,2,* Fang-Ci Chen,3 Jia-Qi Shan,3 Yu-Qiang Shan,3,4 Chen-Xi Lv,3 Zhi-Qiang Zhu,5 Yi-Ren He,5 Lu-Lu Zhai5 1Department of Colorectal Surgery and Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, People’s Republic of China; 2Department of General Surgery, The Second People’s Hospital of Wuhu, Wuhu, 241000, People’s Republic of China; 3The Fourth School of Clinical Medicine, Zhejiang University of Traditional Chinese Medicine, Hangzhou, 310006, People’s Republic of China; 4Department of Gastrointestinal Surgery, Hangzhou First People’s Hospital Affiliated to Westlake University School of Medicine, Hangzhou, 310006, People’s Republic of China; 5Department of General Surgery, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lu-Lu Zhai; Yi-Ren He, Email jackyzhai123@163.com; heyiren2007@163.comBackground: Tumor is a complex and dynamic ecosystem formed by the interaction of numerous diverse cells types and the microenvironments they inhabit. Determining how cellular states change and develop distinct cellular communities in response to the tumor microenvironment is critical to understanding cancer progression. Tumour-associated macrophages (TAMs) are an important component of the tumour microenvironment and play a crucial role in cancer progression. This study was designed to identify cell-state-specific M2 macrophage markers associated with gastric cancer (GC) prognosis through integrative analysis of single-cell RNA sequencing (scRNA-seq) and bulk RNA-seq data using a machine learning framework named EcoTyper.Results: The results showed that TAMs were classified into M1 macrophages, M2 macrophages, monocytes, undefined macrophages and dendritic cells, with M2 macrophages predominating. EcoTyper assigned macrophages to different cell states and ecotypes. A total of 168 cell-state-specific M2 macrophage markers were obtained by integrative analysis of scRNA-seq and bulk RNA-seq data. These markers could categorize GC patients into two clusters (clusters A and B) with different survival and M2 macrophages infiltration abundance. Cell adhesion molecules, cytokine-cytokine receptor interaction, JAK/STAT pathway, MAPK pathway were significantly enriched in cluster A, which had worse survival and higher M2 macrophages infiltration.Conclusion: In conclusion, this study profiles a single-cell atlas of intratumor heterogeneity and defines the cell states and ecotypes of TAMs in GC. Furthermore, we have identified prognostically relevant cell-state-specific M2 macrophage markers. These findings provide novel insights into the tumor ecosystem and cancer progression.Keywords: Tumor-associated macrophages, Gastric cancer, Ecotype, Cell state, Prognosis
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spelling doaj-art-be599f56d0cc4c469dd752837d293eb22025-08-20T02:34:31ZengDove Medical PressImmunoTargets and Therapy2253-15562024-12-01Volume 1372173498252Integrated Analysis of Single-Cell and Bulk RNA-Sequencing Based on EcoTyper Machine Learning Framework Identifies Cell-State-Specific M2 Macrophage Markers Associated with Gastric Cancer PrognosisZhu AKLi GYChen FCShan JQShan YQLv CXZhu ZQHe YRZhai LLA-Kao Zhu,1,* Guang-Yao Li,2,* Fang-Ci Chen,3 Jia-Qi Shan,3 Yu-Qiang Shan,3,4 Chen-Xi Lv,3 Zhi-Qiang Zhu,5 Yi-Ren He,5 Lu-Lu Zhai5 1Department of Colorectal Surgery and Oncology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, 310009, People’s Republic of China; 2Department of General Surgery, The Second People’s Hospital of Wuhu, Wuhu, 241000, People’s Republic of China; 3The Fourth School of Clinical Medicine, Zhejiang University of Traditional Chinese Medicine, Hangzhou, 310006, People’s Republic of China; 4Department of Gastrointestinal Surgery, Hangzhou First People’s Hospital Affiliated to Westlake University School of Medicine, Hangzhou, 310006, People’s Republic of China; 5Department of General Surgery, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, 230001, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lu-Lu Zhai; Yi-Ren He, Email jackyzhai123@163.com; heyiren2007@163.comBackground: Tumor is a complex and dynamic ecosystem formed by the interaction of numerous diverse cells types and the microenvironments they inhabit. Determining how cellular states change and develop distinct cellular communities in response to the tumor microenvironment is critical to understanding cancer progression. Tumour-associated macrophages (TAMs) are an important component of the tumour microenvironment and play a crucial role in cancer progression. This study was designed to identify cell-state-specific M2 macrophage markers associated with gastric cancer (GC) prognosis through integrative analysis of single-cell RNA sequencing (scRNA-seq) and bulk RNA-seq data using a machine learning framework named EcoTyper.Results: The results showed that TAMs were classified into M1 macrophages, M2 macrophages, monocytes, undefined macrophages and dendritic cells, with M2 macrophages predominating. EcoTyper assigned macrophages to different cell states and ecotypes. A total of 168 cell-state-specific M2 macrophage markers were obtained by integrative analysis of scRNA-seq and bulk RNA-seq data. These markers could categorize GC patients into two clusters (clusters A and B) with different survival and M2 macrophages infiltration abundance. Cell adhesion molecules, cytokine-cytokine receptor interaction, JAK/STAT pathway, MAPK pathway were significantly enriched in cluster A, which had worse survival and higher M2 macrophages infiltration.Conclusion: In conclusion, this study profiles a single-cell atlas of intratumor heterogeneity and defines the cell states and ecotypes of TAMs in GC. Furthermore, we have identified prognostically relevant cell-state-specific M2 macrophage markers. These findings provide novel insights into the tumor ecosystem and cancer progression.Keywords: Tumor-associated macrophages, Gastric cancer, Ecotype, Cell state, Prognosishttps://www.dovepress.com/integrated-analysis-of-single-cell-and-bulk-rna-sequencing-based-on-ec-peer-reviewed-fulltext-article-ITTtumor-associated macrophagesgastric cancerecotypecell stateprognosis
spellingShingle Zhu AK
Li GY
Chen FC
Shan JQ
Shan YQ
Lv CX
Zhu ZQ
He YR
Zhai LL
Integrated Analysis of Single-Cell and Bulk RNA-Sequencing Based on EcoTyper Machine Learning Framework Identifies Cell-State-Specific M2 Macrophage Markers Associated with Gastric Cancer Prognosis
ImmunoTargets and Therapy
tumor-associated macrophages
gastric cancer
ecotype
cell state
prognosis
title Integrated Analysis of Single-Cell and Bulk RNA-Sequencing Based on EcoTyper Machine Learning Framework Identifies Cell-State-Specific M2 Macrophage Markers Associated with Gastric Cancer Prognosis
title_full Integrated Analysis of Single-Cell and Bulk RNA-Sequencing Based on EcoTyper Machine Learning Framework Identifies Cell-State-Specific M2 Macrophage Markers Associated with Gastric Cancer Prognosis
title_fullStr Integrated Analysis of Single-Cell and Bulk RNA-Sequencing Based on EcoTyper Machine Learning Framework Identifies Cell-State-Specific M2 Macrophage Markers Associated with Gastric Cancer Prognosis
title_full_unstemmed Integrated Analysis of Single-Cell and Bulk RNA-Sequencing Based on EcoTyper Machine Learning Framework Identifies Cell-State-Specific M2 Macrophage Markers Associated with Gastric Cancer Prognosis
title_short Integrated Analysis of Single-Cell and Bulk RNA-Sequencing Based on EcoTyper Machine Learning Framework Identifies Cell-State-Specific M2 Macrophage Markers Associated with Gastric Cancer Prognosis
title_sort integrated analysis of single cell and bulk rna sequencing based on ecotyper machine learning framework identifies cell state specific m2 macrophage markers associated with gastric cancer prognosis
topic tumor-associated macrophages
gastric cancer
ecotype
cell state
prognosis
url https://www.dovepress.com/integrated-analysis-of-single-cell-and-bulk-rna-sequencing-based-on-ec-peer-reviewed-fulltext-article-ITT
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