Tradeoffs between proliferation and transmission in virus evolution– insights from evolutionary and functional analyses of SARS-CoV-2

Tradeoffs between proliferation and transmission in virus evolution– insights from evolutionary and functional analyses of SARS-CoV-2

Abstract To be successful, a virus must maintain high between-host transmissibility while also effectively adapting within hosts. The impact of these potentially conflicting demands on viral genetic diversity and adaptation remains largely unexplored. These modes of adaptation can induce uncorrelate...

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Main Authors: Jui-Hung Tai, Ding-Chin Lee, Hsin-Fu Lin, Tai-Ling Chao, Yongsen Ruan, Ya-Wen Cheng, Yu-Chi Chou, You-Yu Lin, Sui-Yuan Chang, Pei-Jer Chen, Shiou-Hwei Yeh, Hurng-Yi Wang
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Virology Journal
Subjects:
Pleiotropy
Genetic diversity
Spike M1237I
Frequency spectrum
Epistatic interactions
Online Access:https://doi.org/10.1186/s12985-025-02727-5
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